Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance
We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a tripl...
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| Veröffentlicht in: | British journal of haematology 1998-12, Vol.103 (4), p.1161-1163 |
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| container_title | British journal of haematology |
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| creator | Ackermann, Jutta Meidlinger, Petra Zojer, Niklas Gisslinger, Heinz Ludwig, Heinz Huber, Heinz Drach, Johannes |
| description | We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence in situ hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS. |
| doi_str_mv | 10.1046/j.1365-2141.1998.01124.x |
| format | Article |
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We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence in situ hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1998.01124.x</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Hematology ; Immunodeficiencies. 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We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence in situ hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.</description><subject>Biological and medical sciences</subject><subject>Hematology</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>interphase FISH</subject><subject>Medical sciences</subject><subject>MGUS</subject><subject>p53 gene</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNkM1u3CAURlHVSp2meQdUdWuXa_yDF12kUdu0ipRNskaALwkjDFPwaDJ5-uBM1G67Aume74N7CKHAamBt_2VbA--7qoEWahhHUTOApq0f35DN38FbsmGMDVUJiPfkQ85bxoCzDjbk6UJnDAZptHTXcTqhx8XFkKkLVMeAdFYpxQPdeZVnRQ16n19gtTgMS6YHtzzQOYZofAzK03s1z7FMH44rtg8TTrhgml3AiWZ3H5x1RpUnP5J3VvmM56_nGbn78f328qq6vvn56_LiujItDG0FthW61XxkegTBbc_0gFZYVIIZ7E3TKKWxafk06mnoBtRCK91ztNAx5B0_I59OvbsU_-wxL3Ib96l8NUsYRTfwZuQFEifIpJhzQit3yZXVjxKYXEXLrVx9ytWnXEXLF9HysUQ_v_arbJS3qSzn8r98D4IBK9jXE3ZwHo__XS-__b5ab_wZ5w2TEA</recordid><startdate>199812</startdate><enddate>199812</enddate><creator>Ackermann, Jutta</creator><creator>Meidlinger, Petra</creator><creator>Zojer, Niklas</creator><creator>Gisslinger, Heinz</creator><creator>Ludwig, Heinz</creator><creator>Huber, Heinz</creator><creator>Drach, Johannes</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>199812</creationdate><title>Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance</title><author>Ackermann, Jutta ; Meidlinger, Petra ; Zojer, Niklas ; Gisslinger, Heinz ; Ludwig, Heinz ; Huber, Heinz ; Drach, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4174-1f48b4b390b9183f60b7ef8fea80ce6c22aabe243d9bd757eb8bab63ef150e353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Hematology</topic><topic>Immunodeficiencies. 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| ispartof | British journal of haematology, 1998-12, Vol.103 (4), p.1161-1163 |
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| language | eng |
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| source | Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Biological and medical sciences Hematology Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology interphase FISH Medical sciences MGUS p53 gene |
| title | Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
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