A comparison of linear and orthogonal regression analysis for local INR determination in ECAA coagulometer studies
International sensitivity index calibrations based on the W.H.O. recommended method depend on orthogonal regression analysis. As this is not readily available in statistical packages, comparison has been made with simple linear regression analysis in a study of coagulometer effects on the Internatio...
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| Veröffentlicht in: | British journal of haematology 1998-09, Vol.102 (4), p.910-917 |
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| container_title | British journal of haematology |
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| creator | POLLER, L VAN DEN BESSELAAR, A. M. H. P JESPERSEN, J TRIPODI, A HOUGHTON, D |
| description | International sensitivity index calibrations based on the W.H.O. recommended method depend on orthogonal regression analysis. As this is not readily available in statistical packages, comparison has been made with simple linear regression analysis in a study of coagulometer effects on the International Normalized Ratio (INR) at 155 European centres. Sets of seven lyophilized normal and 20 lyophilized artificially depleted abnormal plasmas were provided with five coumarin test plasmas and two European Concerted Action on Anticoagulation reference thromboplastins (low International Sensitivity Index (ISI) human and high ISI rabbit). Local ISI based on the artificially depleted lyophilized plasmas using conventional orthogonal regression gave good correction for local coagulometer effects on the human reagent and minimal correction with the rabbit reagent INR. Results were considerably worse after attempts at correction using calibration based on linear regression analysis with both reagents. The results indicate that calibration of coagulometer prothrombin time systems using simple linear regression is not appropriate. |
| doi_str_mv | 10.1046/j.1365-2141.1998.00866.x |
| format | Article |
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Local ISI based on the artificially depleted lyophilized plasmas using conventional orthogonal regression gave good correction for local coagulometer effects on the human reagent and minimal correction with the rabbit reagent INR. Results were considerably worse after attempts at correction using calibration based on linear regression analysis with both reagents. 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Local ISI based on the artificially depleted lyophilized plasmas using conventional orthogonal regression gave good correction for local coagulometer effects on the human reagent and minimal correction with the rabbit reagent INR. Results were considerably worse after attempts at correction using calibration based on linear regression analysis with both reagents. The results indicate that calibration of coagulometer prothrombin time systems using simple linear regression is not appropriate.</description><subject>Biological and medical sciences</subject><subject>Blood coagulation</subject><subject>coagulometers</subject><subject>Hematology</subject><subject>INR</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>linear</subject><subject>Medical sciences</subject><subject>orthogonal</subject><subject>regression</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNkF1PwyAUhonRxDn9D8R423qAlkHizVzmVxZNjPeEtjBZujKhi9u_lzqza6-AvM95OXkQwgRyAgW_XeWE8TKjpCA5kVLkAILzfHeCRsfgFI0AYJKlAXGOLmJcARAGJRmhMMW1X290cNF32Fvcus7ogHXXYB_6T7_0nW5xMMtgYnSJ0em9jy5i6wNufZ3S59d33JjehLXrdD9ArsPz2XTo1stt69dDiGO_bZyJl-jM6jaaq79zjD4e5h-zp2zx9vg8my6yuiCcZ5Qy1ljBQMuJSYs3hSQCaj6pqgYsZ2CFASF5xQoqKyuo5NTWUJZsohlt2BhdH2o3wX9tTezVym9DWj4qIkXJJedFgsQBqoOPMRirNsGtddgrAmrwq1Zq0KgGjWrwq379ql0avfnr1zFJsEF3tYvHeco4TZ8k7O6AfbvW7P9dr-5fntKF_QC5i42-</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>POLLER, L</creator><creator>VAN DEN BESSELAAR, A. 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Sets of seven lyophilized normal and 20 lyophilized artificially depleted abnormal plasmas were provided with five coumarin test plasmas and two European Concerted Action on Anticoagulation reference thromboplastins (low International Sensitivity Index (ISI) human and high ISI rabbit). Local ISI based on the artificially depleted lyophilized plasmas using conventional orthogonal regression gave good correction for local coagulometer effects on the human reagent and minimal correction with the rabbit reagent INR. Results were considerably worse after attempts at correction using calibration based on linear regression analysis with both reagents. The results indicate that calibration of coagulometer prothrombin time systems using simple linear regression is not appropriate.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Publishers</pub><doi>10.1046/j.1365-2141.1998.00866.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of haematology, 1998-09, Vol.102 (4), p.910-917 |
| issn | 0007-1048 1365-2141 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Blood coagulation coagulometers Hematology INR Investigative techniques, diagnostic techniques (general aspects) linear Medical sciences orthogonal regression |
| title | A comparison of linear and orthogonal regression analysis for local INR determination in ECAA coagulometer studies |
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