cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development

cGMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) sensing has emerged as a key regulator of innate immune responses to both exogenous and endogenous DNA. Recent studies reveal critical roles for this pathway in natural antitumor immunity across cancer types as well as in immune checkpo...

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Veröffentlicht in:	Trends in immunology 2018-01, Vol.39 (1), p.44-54
Hauptverfasser:	Ng, Kevin W., Marshall, Erin A., Bell, John C., Lam, Wan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP Animals Antibodies, Blocking - therapeutic use Cancer Carcinogenesis Cell cycle Costimulatory and Inhibitory T-Cell Receptors - immunology Cyclic GMP Cytokines Deoxyribonucleic acid DNA DNA - immunology Humans Immune checkpoint Immune response Immunity, Innate Immunomodulation Immunotherapy Immunotherapy - methods Inflammation Innate immunity Interferon Kinases Lung cancer Membrane Proteins - metabolism Metastases Metastasis Mitochondrial DNA Mutation Neoplasms - immunology Nucleotidyltransferases - metabolism Proteins Roles Sensors Signal Transduction Trends Tumor Escape Tumorigenesis Tumors
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