Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study

The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relativ...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-11, Vol.72 (11), p.1561
Hauptverfasser:	Sillanpää, Elina, Sipilä, Sarianna, Törmäkangas, Timo, Kaprio, Jaakko, Rantanen, Taina
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging - genetics Deoxyribonucleic acid DNA Environmental effects Environmental Exposure Environmental factors Female Forced Expiratory Volume - physiology Genetic factors Genetics Heritability Humans Leukocytes Leukocytes - ultrastructure Lung - physiology Lungs Middle Aged Peripheral blood Respiration Respiratory function Spirometry Telomerase Telomere - genetics Twin studies Twins, Dizygotic Twins, Monozygotic
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creator	Sillanpää, Elina Sipilä, Sarianna Törmäkangas, Timo Kaprio, Jaakko Rantanen, Taina
description	The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Univariate analysis revealed that in LTL, 62% (95% confidence interval 50-72) of the variance was explained by additive genetic and 38% (28-50) by unique environmental factors. For FEV1, FVC, and PEF, the corresponding estimates were 65%-67% for additive genetic and 33%-35% for unique environmental factors. Across the sample, the phenotypic correlation between LTL and FEV1 was modest (r = .104, p = .041). Bivariate correlated factors model revealed that the genetic correlation between LTL and FEV1 was .18 (-0.19 to 0.64) and environmental correlation was -.10 (-0.84 to 0.55). Both LTL and lung function variables are moderately to highly genetically determined. The associations between LTL and the lung function variables were weak. However, the positive genetic correlation point estimate gave minor suggestions that, in a larger sample, genetic factors in common might play a role in the phenotypic correlation between LTL and FEV1. Future studies with larger samples are needed to confirm these preliminary findings.
doi_str_mv	10.1093/gerona/glw178
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Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Univariate analysis revealed that in LTL, 62% (95% confidence interval 50-72) of the variance was explained by additive genetic and 38% (28-50) by unique environmental factors. For FEV1, FVC, and PEF, the corresponding estimates were 65%-67% for additive genetic and 33%-35% for unique environmental factors. Across the sample, the phenotypic correlation between LTL and FEV1 was modest (r = .104, p = .041). Bivariate correlated factors model revealed that the genetic correlation between LTL and FEV1 was .18 (-0.19 to 0.64) and environmental correlation was -.10 (-0.84 to 0.55). Both LTL and lung function variables are moderately to highly genetically determined. The associations between LTL and the lung function variables were weak. However, the positive genetic correlation point estimate gave minor suggestions that, in a larger sample, genetic factors in common might play a role in the phenotypic correlation between LTL and FEV1. Future studies with larger samples are needed to confirm these preliminary findings.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glw178</identifier><identifier>PMID: 27856493</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aging - genetics ; Deoxyribonucleic acid ; DNA ; Environmental effects ; Environmental Exposure ; Environmental factors ; Female ; Forced Expiratory Volume - physiology ; Genetic factors ; Genetics ; Heritability ; Humans ; Leukocytes ; Leukocytes - ultrastructure ; Lung - physiology ; Lungs ; Middle Aged ; Peripheral blood ; Respiration ; Respiratory function ; Spirometry ; Telomerase ; Telomere - genetics ; Twin studies ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2017-11, Vol.72 (11), p.1561</ispartof><rights>The Author 2016. 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Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Univariate analysis revealed that in LTL, 62% (95% confidence interval 50-72) of the variance was explained by additive genetic and 38% (28-50) by unique environmental factors. For FEV1, FVC, and PEF, the corresponding estimates were 65%-67% for additive genetic and 33%-35% for unique environmental factors. 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source	MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects	Aged Aging - genetics Deoxyribonucleic acid DNA Environmental effects Environmental Exposure Environmental factors Female Forced Expiratory Volume - physiology Genetic factors Genetics Heritability Humans Leukocytes Leukocytes - ultrastructure Lung - physiology Lungs Middle Aged Peripheral blood Respiration Respiratory function Spirometry Telomerase Telomere - genetics Twin studies Twins, Dizygotic Twins, Monozygotic
title	Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study
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