Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study

The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relativ...

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Veröffentlicht in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-11, Vol.72 (11), p.1561
Hauptverfasser: Sillanpää, Elina, Sipilä, Sarianna, Törmäkangas, Timo, Kaprio, Jaakko, Rantanen, Taina
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container_title The journals of gerontology. Series A, Biological sciences and medical sciences
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creator Sillanpää, Elina
Sipilä, Sarianna
Törmäkangas, Timo
Kaprio, Jaakko
Rantanen, Taina
description The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Univariate analysis revealed that in LTL, 62% (95% confidence interval 50-72) of the variance was explained by additive genetic and 38% (28-50) by unique environmental factors. For FEV1, FVC, and PEF, the corresponding estimates were 65%-67% for additive genetic and 33%-35% for unique environmental factors. Across the sample, the phenotypic correlation between LTL and FEV1 was modest (r = .104, p = .041). Bivariate correlated factors model revealed that the genetic correlation between LTL and FEV1 was .18 (-0.19 to 0.64) and environmental correlation was -.10 (-0.84 to 0.55). Both LTL and lung function variables are moderately to highly genetically determined. The associations between LTL and the lung function variables were weak. However, the positive genetic correlation point estimate gave minor suggestions that, in a larger sample, genetic factors in common might play a role in the phenotypic correlation between LTL and FEV1. Future studies with larger samples are needed to confirm these preliminary findings.
doi_str_mv 10.1093/gerona/glw178
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Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Univariate analysis revealed that in LTL, 62% (95% confidence interval 50-72) of the variance was explained by additive genetic and 38% (28-50) by unique environmental factors. For FEV1, FVC, and PEF, the corresponding estimates were 65%-67% for additive genetic and 33%-35% for unique environmental factors. Across the sample, the phenotypic correlation between LTL and FEV1 was modest (r = .104, p = .041). Bivariate correlated factors model revealed that the genetic correlation between LTL and FEV1 was .18 (-0.19 to 0.64) and environmental correlation was -.10 (-0.84 to 0.55). Both LTL and lung function variables are moderately to highly genetically determined. The associations between LTL and the lung function variables were weak. 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1758-535X
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source MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Aged
Aging - genetics
Deoxyribonucleic acid
DNA
Environmental effects
Environmental Exposure
Environmental factors
Female
Forced Expiratory Volume - physiology
Genetic factors
Genetics
Heritability
Humans
Leukocytes
Leukocytes - ultrastructure
Lung - physiology
Lungs
Middle Aged
Peripheral blood
Respiration
Respiratory function
Spirometry
Telomerase
Telomere - genetics
Twin studies
Twins, Dizygotic
Twins, Monozygotic
title Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study
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