A phase I study for adjuvant chemotherapy of gemcitabine plus S-1 in patients with biliary tract cancer undergoing curative resection without major hepatectomy (KHBO1202)

Purpose To determine the recommended dose (RD) of gemcitabine (GEM) plus S-1 (GS) in curatively resected biliary tract cancer (BTC) patients without major hepatectomy. Methods A standard 3 + 3 dose-escalation design was used with planned dose levels (mg/m 2 ) of GEM (administered intravenously on da...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2018-03, Vol.81 (3), p.461-468
Hauptverfasser:	Yanagimoto, Hiroaki, Toyokawa, Hideyoshi, Sakai, Daisuke, Wada, Hiroshi, Satoi, Sohei, Yamamoto, Tomohisa, Nagano, Hiroaki, Toyoda, Masanori, Ajiki, Tetsuo, Satake, Hironaga, Tsuji, Akihito, Miyamoto, Atsushi, Tsujie, Masanori, Takemura, Shigekazu, Yanagihara, Kazuhiro, Ioka, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - pharmacokinetics Biliary tract Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - pathology Biliary Tract Neoplasms - surgery Biliary Tract Surgical Procedures - methods Cancer Cancer Research Chemotherapy Chemotherapy, Adjuvant - methods Cholangiocarcinoma Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacokinetics Design standards Dose-Response Relationship, Drug Drug Administration Schedule Drug Combinations Drug Monitoring - methods Drug-Related Side Effects and Adverse Reactions - diagnosis Drug-Related Side Effects and Adverse Reactions - etiology Female Gemcitabine Hepatectomy Humans Male Maximum Tolerated Dose Medicine Medicine & Public Health Neutropenia Oncology Original Article Oxonic Acid - administration & dosage Oxonic Acid - adverse effects Oxonic Acid - pharmacokinetics Patients Pharmacology/Toxicology Survival Survival Analysis Tegafur - administration & dosage Tegafur - adverse effects Tegafur - pharmacokinetics Toxicity Treatment Outcome
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