Graft failure following reduced‐intensity cord blood transplantation for adult patients
Summary We reviewed the medical records of 123 adult reduced‐intensity cord blood transplantation (RI‐CBT) recipients to investigate the clinical features of graft failure after RI‐CBT. Nine (7·3%) had graft failure, and were classified as graft rejection rather than primary graft failure; they show...
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| Veröffentlicht in: | British journal of haematology 2006-01, Vol.132 (1), p.36-41 |
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| creator | Narimatsu, Hiroto Kami, Masahiro Miyakoshi, Shigesaburo Murashige, Naoko Yuji, Koichiro Hamaki, Tamae Masuoka, Kazuhiro Kusumi, Eiji Kishi, Yukiko Matsumura, Tomoko Wake, Atsushi Morinaga, Shinichi Kanda, Yoshinobu Taniguchi, Shuichi |
| description | Summary
We reviewed the medical records of 123 adult reduced‐intensity cord blood transplantation (RI‐CBT) recipients to investigate the clinical features of graft failure after RI‐CBT. Nine (7·3%) had graft failure, and were classified as graft rejection rather than primary graft failure; they showed peripheral cytopenia with complete loss of donor‐type haematopoiesis, implying destruction of donor cells by immunological mechanisms rather than poor graft function. Three of them died of bacterial or fungal infection during neutropenia. Two recovered autologous haematopoiesis. The remaining four patients underwent a second RI‐CBT and developed severe regimen‐related toxicities. One died of pneumonia on day 8, and the other three achieved engraftment. Two of them died of transplant‐related mortality, and the other survived without disease progression for 9·0 months after the second RI‐CBT. In total, seven of the nine patients with graft failure died. The median survival of those with graft failure was 3·8 months (range, 0·9–15·4). Graft failure is a serious complication of RI‐CBT. As host T cells cannot completely be eliminated by reduced‐intensity preparative regimens, we need to be aware of the difficulty in differentiating graft rejection from other causes of graft failure following RI‐CBT. Further studies are warranted to establish optimal diagnostic and treatment strategies. |
| doi_str_mv | 10.1111/j.1365-2141.2005.05832.x |
| format | Article |
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We reviewed the medical records of 123 adult reduced‐intensity cord blood transplantation (RI‐CBT) recipients to investigate the clinical features of graft failure after RI‐CBT. Nine (7·3%) had graft failure, and were classified as graft rejection rather than primary graft failure; they showed peripheral cytopenia with complete loss of donor‐type haematopoiesis, implying destruction of donor cells by immunological mechanisms rather than poor graft function. Three of them died of bacterial or fungal infection during neutropenia. Two recovered autologous haematopoiesis. The remaining four patients underwent a second RI‐CBT and developed severe regimen‐related toxicities. One died of pneumonia on day 8, and the other three achieved engraftment. Two of them died of transplant‐related mortality, and the other survived without disease progression for 9·0 months after the second RI‐CBT. In total, seven of the nine patients with graft failure died. The median survival of those with graft failure was 3·8 months (range, 0·9–15·4). Graft failure is a serious complication of RI‐CBT. As host T cells cannot completely be eliminated by reduced‐intensity preparative regimens, we need to be aware of the difficulty in differentiating graft rejection from other causes of graft failure following RI‐CBT. Further studies are warranted to establish optimal diagnostic and treatment strategies.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2005.05832.x</identifier><identifier>PMID: 16371018</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; chimaerism ; Cord Blood Stem Cell Transplantation - methods ; Female ; graft failure ; Graft Rejection ; Graft Survival ; Graft vs Host Disease - diagnosis ; graft‐versus‐host disease ; Hematologic and hematopoietic diseases ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - therapy ; Hematology ; Histocompatibility Testing ; Humans ; Male ; Medical sciences ; Middle Aged ; Neutropenia - complications ; Opportunistic Infections - complications ; second transplantation ; Treatment Outcome</subject><ispartof>British journal of haematology, 2006-01, Vol.132 (1), p.36-41</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Jan 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5402-baebbe53d6d4355416453a7ecdd76a76cc756bdef23b39bbce141cec03db80ac3</citedby><cites>FETCH-LOGICAL-c5402-baebbe53d6d4355416453a7ecdd76a76cc756bdef23b39bbce141cec03db80ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2005.05832.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2005.05832.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,1435,27933,27934,45583,45584,46418,46842</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17476944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16371018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narimatsu, Hiroto</creatorcontrib><creatorcontrib>Kami, Masahiro</creatorcontrib><creatorcontrib>Miyakoshi, Shigesaburo</creatorcontrib><creatorcontrib>Murashige, Naoko</creatorcontrib><creatorcontrib>Yuji, Koichiro</creatorcontrib><creatorcontrib>Hamaki, Tamae</creatorcontrib><creatorcontrib>Masuoka, Kazuhiro</creatorcontrib><creatorcontrib>Kusumi, Eiji</creatorcontrib><creatorcontrib>Kishi, Yukiko</creatorcontrib><creatorcontrib>Matsumura, Tomoko</creatorcontrib><creatorcontrib>Wake, Atsushi</creatorcontrib><creatorcontrib>Morinaga, Shinichi</creatorcontrib><creatorcontrib>Kanda, Yoshinobu</creatorcontrib><creatorcontrib>Taniguchi, Shuichi</creatorcontrib><title>Graft failure following reduced‐intensity cord blood transplantation for adult patients</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
We reviewed the medical records of 123 adult reduced‐intensity cord blood transplantation (RI‐CBT) recipients to investigate the clinical features of graft failure after RI‐CBT. Nine (7·3%) had graft failure, and were classified as graft rejection rather than primary graft failure; they showed peripheral cytopenia with complete loss of donor‐type haematopoiesis, implying destruction of donor cells by immunological mechanisms rather than poor graft function. Three of them died of bacterial or fungal infection during neutropenia. Two recovered autologous haematopoiesis. The remaining four patients underwent a second RI‐CBT and developed severe regimen‐related toxicities. One died of pneumonia on day 8, and the other three achieved engraftment. Two of them died of transplant‐related mortality, and the other survived without disease progression for 9·0 months after the second RI‐CBT. In total, seven of the nine patients with graft failure died. The median survival of those with graft failure was 3·8 months (range, 0·9–15·4). Graft failure is a serious complication of RI‐CBT. As host T cells cannot completely be eliminated by reduced‐intensity preparative regimens, we need to be aware of the difficulty in differentiating graft rejection from other causes of graft failure following RI‐CBT. Further studies are warranted to establish optimal diagnostic and treatment strategies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>chimaerism</subject><subject>Cord Blood Stem Cell Transplantation - methods</subject><subject>Female</subject><subject>graft failure</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Graft vs Host Disease - diagnosis</subject><subject>graft‐versus‐host disease</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hematology</subject><subject>Histocompatibility Testing</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutropenia - complications</subject><subject>Opportunistic Infections - complications</subject><subject>second transplantation</subject><subject>Treatment Outcome</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL1u2zAURokiReOmfYWACJBRyqVISvKQITESJ0WALu3QieCfChm06JAUYm95hD5jn6RUbMRr78IL8nyX5EEIEyhJrqtVSWjNi4owUlYAvATe0qrcfkCz94MTNAOApiDA2lP0OcYVAKHAySd0SmraECDtDP1aBtkl3MnejcHizjvnX_rhNw7WjNqav69_-iHZIfZph7UPBivnvcEpyCFunBySTL0fcjBgaUaX8CZv2CHFL-hjJ120Xw_rGfp5f_dj8VA8fV8-Lm6eCs0ZVIWSVinLqakNo5wzUjNOZWO1MU0tm1rrhtfK2K6iis6V0jb_TVsN1KgWpKZn6GI_dxP882hjEis_hiFfKci85UA4azPU7iEdfIzBdmIT-rUMO0FATErFSkzmxGROTErFm1KxzdHzw_xRra05Bg8OM3B5AGTU0nXZjO7jkWtYU88Zy9z1nnvpnd399wPE7beHqaP_ANANlK8</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Narimatsu, Hiroto</creator><creator>Kami, Masahiro</creator><creator>Miyakoshi, Shigesaburo</creator><creator>Murashige, Naoko</creator><creator>Yuji, Koichiro</creator><creator>Hamaki, Tamae</creator><creator>Masuoka, Kazuhiro</creator><creator>Kusumi, Eiji</creator><creator>Kishi, Yukiko</creator><creator>Matsumura, Tomoko</creator><creator>Wake, Atsushi</creator><creator>Morinaga, Shinichi</creator><creator>Kanda, Yoshinobu</creator><creator>Taniguchi, Shuichi</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200601</creationdate><title>Graft failure following reduced‐intensity cord blood transplantation for adult patients</title><author>Narimatsu, Hiroto ; Kami, Masahiro ; Miyakoshi, Shigesaburo ; Murashige, Naoko ; Yuji, Koichiro ; Hamaki, Tamae ; Masuoka, Kazuhiro ; Kusumi, Eiji ; Kishi, Yukiko ; Matsumura, Tomoko ; Wake, Atsushi ; Morinaga, Shinichi ; Kanda, Yoshinobu ; Taniguchi, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5402-baebbe53d6d4355416453a7ecdd76a76cc756bdef23b39bbce141cec03db80ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>chimaerism</topic><topic>Cord Blood Stem Cell Transplantation - methods</topic><topic>Female</topic><topic>graft failure</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Graft vs Host Disease - diagnosis</topic><topic>graft‐versus‐host disease</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematologic Neoplasms - complications</topic><topic>Hematologic Neoplasms - therapy</topic><topic>Hematology</topic><topic>Histocompatibility Testing</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutropenia - complications</topic><topic>Opportunistic Infections - complications</topic><topic>second transplantation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Narimatsu, Hiroto</creatorcontrib><creatorcontrib>Kami, Masahiro</creatorcontrib><creatorcontrib>Miyakoshi, Shigesaburo</creatorcontrib><creatorcontrib>Murashige, Naoko</creatorcontrib><creatorcontrib>Yuji, Koichiro</creatorcontrib><creatorcontrib>Hamaki, Tamae</creatorcontrib><creatorcontrib>Masuoka, Kazuhiro</creatorcontrib><creatorcontrib>Kusumi, Eiji</creatorcontrib><creatorcontrib>Kishi, Yukiko</creatorcontrib><creatorcontrib>Matsumura, Tomoko</creatorcontrib><creatorcontrib>Wake, Atsushi</creatorcontrib><creatorcontrib>Morinaga, Shinichi</creatorcontrib><creatorcontrib>Kanda, Yoshinobu</creatorcontrib><creatorcontrib>Taniguchi, Shuichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Narimatsu, Hiroto</au><au>Kami, Masahiro</au><au>Miyakoshi, Shigesaburo</au><au>Murashige, Naoko</au><au>Yuji, Koichiro</au><au>Hamaki, Tamae</au><au>Masuoka, Kazuhiro</au><au>Kusumi, Eiji</au><au>Kishi, Yukiko</au><au>Matsumura, Tomoko</au><au>Wake, Atsushi</au><au>Morinaga, Shinichi</au><au>Kanda, Yoshinobu</au><au>Taniguchi, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Graft failure following reduced‐intensity cord blood transplantation for adult patients</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2006-01</date><risdate>2006</risdate><volume>132</volume><issue>1</issue><spage>36</spage><epage>41</epage><pages>36-41</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
We reviewed the medical records of 123 adult reduced‐intensity cord blood transplantation (RI‐CBT) recipients to investigate the clinical features of graft failure after RI‐CBT. Nine (7·3%) had graft failure, and were classified as graft rejection rather than primary graft failure; they showed peripheral cytopenia with complete loss of donor‐type haematopoiesis, implying destruction of donor cells by immunological mechanisms rather than poor graft function. Three of them died of bacterial or fungal infection during neutropenia. Two recovered autologous haematopoiesis. The remaining four patients underwent a second RI‐CBT and developed severe regimen‐related toxicities. One died of pneumonia on day 8, and the other three achieved engraftment. Two of them died of transplant‐related mortality, and the other survived without disease progression for 9·0 months after the second RI‐CBT. In total, seven of the nine patients with graft failure died. The median survival of those with graft failure was 3·8 months (range, 0·9–15·4). Graft failure is a serious complication of RI‐CBT. As host T cells cannot completely be eliminated by reduced‐intensity preparative regimens, we need to be aware of the difficulty in differentiating graft rejection from other causes of graft failure following RI‐CBT. Further studies are warranted to establish optimal diagnostic and treatment strategies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16371018</pmid><doi>10.1111/j.1365-2141.2005.05832.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences chimaerism Cord Blood Stem Cell Transplantation - methods Female graft failure Graft Rejection Graft Survival Graft vs Host Disease - diagnosis graft‐versus‐host disease Hematologic and hematopoietic diseases Hematologic Neoplasms - complications Hematologic Neoplasms - therapy Hematology Histocompatibility Testing Humans Male Medical sciences Middle Aged Neutropenia - complications Opportunistic Infections - complications second transplantation Treatment Outcome |
| title | Graft failure following reduced‐intensity cord blood transplantation for adult patients |
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