Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis—A Review

Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-p...

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Veröffentlicht in:	Neurochemical research 2018, Vol.43 (1), p.66-78
Hauptverfasser:	Shin, Eun-Joo, Tran, Hai-Quyen, Nguyen, Phuong-Tram, Jeong, Ji Hoon, Nah, Seung-Yeol, Jang, Choon-Gon, Nabeshima, Toshitaka, Kim, Hyoung-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Animals Apoptosis Apoptosis - drug effects Biochemistry Biocompatibility Biomedicine Cell Biology Central Nervous System Stimulants - pharmacology Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Drug abuse Electron transport Electron transport chain Feedback loops Humans Impairment In vivo methods and tests Inflammation Kinases Krebs cycle Metabolism Methamphetamine Methamphetamine - pharmacology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Neurochemistry Neurology Neurosciences Neurotoxicity Organelles Original Paper Oxidative stress Oxidative Stress - drug effects Positive feedback Protein kinase Protein kinase C Toxicity Tricarboxylic acid cycle
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