Post‐menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women
The effects of post‐menopausal hormone therapy (HRT) on blood coagulation in elderly women are not well defined. We studied associations of HRT use with levels of natural anticoagulant proteins in a cross‐sectional study of 3393 women ≥ 65 years of age participating in the Cardiovascular Health Stud...
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| Veröffentlicht in: | British journal of haematology 2001-07, Vol.114 (1), p.162-168 |
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| creator | Cushman, Mary Psaty, Bruce M. Meilahn, Elaine N. Dobs, Adrian S. Kuller, Lewis H. |
| description | The effects of post‐menopausal hormone therapy (HRT) on blood coagulation in elderly women are not well defined. We studied associations of HRT use with levels of natural anticoagulant proteins in a cross‐sectional study of 3393 women ≥ 65 years of age participating in the Cardiovascular Health Study. Protein C antigen and antithrombin were measured in all users (n = 230 unopposed oestrogen; 60 oestrogen/progestin) and a comparison group of 196 age‐ and race‐matched non‐users. Compared with non‐users, oestrogen use was associated with higher protein C (4·80 vs. 4·30 µg/ml, P 0·05). In both user groups, antithrombin was lower than in non‐users (109% for each vs. 115% in non‐users, P |
| doi_str_mv | 10.1046/j.1365-2141.2001.02911.x |
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We studied associations of HRT use with levels of natural anticoagulant proteins in a cross‐sectional study of 3393 women ≥ 65 years of age participating in the Cardiovascular Health Study. Protein C antigen and antithrombin were measured in all users (n = 230 unopposed oestrogen; 60 oestrogen/progestin) and a comparison group of 196 age‐ and race‐matched non‐users. Compared with non‐users, oestrogen use was associated with higher protein C (4·80 vs. 4·30 µg/ml, P < 0·01). Results were similar for oestrogen/progestin (P > 0·05). In both user groups, antithrombin was lower than in non‐users (109% for each vs. 115% in non‐users, P < 0·001). Adjustment for factors related to prescription of HRT and to anticoagulant protein levels had little impact on the results. For antithrombin, associations with HRT were larger for thinner Caucasian women and black women. Venous thrombosis from HRT may be mediated partly by alterations in antithrombin, but not protein C concentrations. This study extends previous observations to older women, the group at highest risk of venous thromboembolism. Studies of HRT‐induced alterations in anticoagulant function in relation to the occurrence of thrombosis with HRT are required.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2001.02911.x</identifier><identifier>PMID: 11472362</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>African Continental Ancestry Group ; Aged ; antithrombin III ; Antithrombins - analysis ; Biological and medical sciences ; blood coagulation ; Body Mass Index ; Cross-Sectional Studies ; Drug toxicity and drugs side effects treatment ; Estrogen Replacement Therapy - adverse effects ; European Continental Ancestry Group ; Female ; Hematology ; Humans ; Logistic Models ; Medical sciences ; oestrogen replacement therapy ; Pharmacology. 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We studied associations of HRT use with levels of natural anticoagulant proteins in a cross‐sectional study of 3393 women ≥ 65 years of age participating in the Cardiovascular Health Study. Protein C antigen and antithrombin were measured in all users (n = 230 unopposed oestrogen; 60 oestrogen/progestin) and a comparison group of 196 age‐ and race‐matched non‐users. Compared with non‐users, oestrogen use was associated with higher protein C (4·80 vs. 4·30 µg/ml, P < 0·01). Results were similar for oestrogen/progestin (P > 0·05). In both user groups, antithrombin was lower than in non‐users (109% for each vs. 115% in non‐users, P < 0·001). Adjustment for factors related to prescription of HRT and to anticoagulant protein levels had little impact on the results. For antithrombin, associations with HRT were larger for thinner Caucasian women and black women. Venous thrombosis from HRT may be mediated partly by alterations in antithrombin, but not protein C concentrations. This study extends previous observations to older women, the group at highest risk of venous thromboembolism. Studies of HRT‐induced alterations in anticoagulant function in relation to the occurrence of thrombosis with HRT are required.</description><subject>African Continental Ancestry Group</subject><subject>Aged</subject><subject>antithrombin III</subject><subject>Antithrombins - analysis</subject><subject>Biological and medical sciences</subject><subject>blood coagulation</subject><subject>Body Mass Index</subject><subject>Cross-Sectional Studies</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Estrogen Replacement Therapy - adverse effects</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>oestrogen replacement therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause - blood</subject><subject>Postmenopause - ethnology</subject><subject>Progestins - adverse effects</subject><subject>protein C</subject><subject>Protein C - analysis</subject><subject>Risk Factors</subject><subject>Toxicity: cardiovascular system</subject><subject>venous thrombosis</subject><subject>Venous Thrombosis - etiology</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtO3DAUhi1EBcPlFZCFxDLBx_Y49oJFO2qBCqldwNpyHEeTUWIPdkYwuz4Cz9gnqcOMYFvJki_n-4-PPoQwkBIIF9erEpiYFxQ4lJQQKAlVAOXrAZp9FA7RjBBSFTkgj9FJSqsMMjKHI3QMwCvKBJ0h-zuk8e-ft8H5sDabZHq8DHEI3uFx6aJZb7HxDbbBW-fHaMYu-IRDi9cxjK7zePFeN37sxmUMQ52f8nJ942K_xS8hNz5DX1rTJ3e-30_R04_vj4u74uHX7f3i60NhOaVQtBUlLZNz1QhBJDDnZD1XyrC2IqaurbTcWSqrWlCqlK3znTUNr5msVANcsVN0ueubZ3veuDTqVdhEn7_UoCSXVUVEhuQOsjGkFF2r17EbTNxqIHqSq1d6cqgnh3qSq9_l6tccvdj339SDaz6De5sZuNoDJlnTt9F426VPjhMhhILM3ey4l6532_8eQH_7eTed2D_Dj5Zz</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Cushman, Mary</creator><creator>Psaty, Bruce M.</creator><creator>Meilahn, Elaine N.</creator><creator>Dobs, Adrian S.</creator><creator>Kuller, Lewis H.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200107</creationdate><title>Post‐menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women</title><author>Cushman, Mary ; Psaty, Bruce M. ; Meilahn, Elaine N. ; Dobs, Adrian S. ; Kuller, Lewis H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4221-f720f3859d660813ee8b599a3f70abbc8c4ec287b62299cb8c43dd4b3879d1493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>African Continental Ancestry Group</topic><topic>Aged</topic><topic>antithrombin III</topic><topic>Antithrombins - analysis</topic><topic>Biological and medical sciences</topic><topic>blood coagulation</topic><topic>Body Mass Index</topic><topic>Cross-Sectional Studies</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Estrogen Replacement Therapy - adverse effects</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>oestrogen replacement therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause - blood</topic><topic>Postmenopause - ethnology</topic><topic>Progestins - adverse effects</topic><topic>protein C</topic><topic>Protein C - analysis</topic><topic>Risk Factors</topic><topic>Toxicity: cardiovascular system</topic><topic>venous thrombosis</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cushman, Mary</creatorcontrib><creatorcontrib>Psaty, Bruce M.</creatorcontrib><creatorcontrib>Meilahn, Elaine N.</creatorcontrib><creatorcontrib>Dobs, Adrian S.</creatorcontrib><creatorcontrib>Kuller, Lewis H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cushman, Mary</au><au>Psaty, Bruce M.</au><au>Meilahn, Elaine N.</au><au>Dobs, Adrian S.</au><au>Kuller, Lewis H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post‐menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2001-07</date><risdate>2001</risdate><volume>114</volume><issue>1</issue><spage>162</spage><epage>168</epage><pages>162-168</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>The effects of post‐menopausal hormone therapy (HRT) on blood coagulation in elderly women are not well defined. We studied associations of HRT use with levels of natural anticoagulant proteins in a cross‐sectional study of 3393 women ≥ 65 years of age participating in the Cardiovascular Health Study. Protein C antigen and antithrombin were measured in all users (n = 230 unopposed oestrogen; 60 oestrogen/progestin) and a comparison group of 196 age‐ and race‐matched non‐users. Compared with non‐users, oestrogen use was associated with higher protein C (4·80 vs. 4·30 µg/ml, P < 0·01). Results were similar for oestrogen/progestin (P > 0·05). In both user groups, antithrombin was lower than in non‐users (109% for each vs. 115% in non‐users, P < 0·001). Adjustment for factors related to prescription of HRT and to anticoagulant protein levels had little impact on the results. For antithrombin, associations with HRT were larger for thinner Caucasian women and black women. Venous thrombosis from HRT may be mediated partly by alterations in antithrombin, but not protein C concentrations. This study extends previous observations to older women, the group at highest risk of venous thromboembolism. Studies of HRT‐induced alterations in anticoagulant function in relation to the occurrence of thrombosis with HRT are required.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11472362</pmid><doi>10.1046/j.1365-2141.2001.02911.x</doi><tpages>7</tpages></addata></record> |
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| subjects | African Continental Ancestry Group Aged antithrombin III Antithrombins - analysis Biological and medical sciences blood coagulation Body Mass Index Cross-Sectional Studies Drug toxicity and drugs side effects treatment Estrogen Replacement Therapy - adverse effects European Continental Ancestry Group Female Hematology Humans Logistic Models Medical sciences oestrogen replacement therapy Pharmacology. Drug treatments Postmenopause - blood Postmenopause - ethnology Progestins - adverse effects protein C Protein C - analysis Risk Factors Toxicity: cardiovascular system venous thrombosis Venous Thrombosis - etiology |
| title | Post‐menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women |
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