Wogonin protects against cisplatin-induced acute kidney injury by targeting RIPK1-mediated necroptosis

Acute kidney injury (AKI), characterized by aggressive inflammatory responses and destruction of renal resident cells, can cause abrupt kidney dysfunction. To date, effective therapy for AKI is lacking. In this study, we evaluated the renoprotective effect of wogonin, an herbal active compound, usin...

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Veröffentlicht in:	Laboratory investigation 2018-01, Vol.98 (1), p.79-94
Hauptverfasser:	Meng, Xiao-Ming, Li, Hai-Di, Wu, Wei-Feng, Ming-Kuen Tang, Patrick, Ren, Gui-Ling, Gao, Li, Li, Xiao-Feng, Yang, Yang, Xu, Tao, Ma, Tao-Tao, Li, Zeng, Huang, Cheng, Zhang, Lei, Lv, Xiong-Wen, Li, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/21 13/31 13/51 13/89 14/28 38/77 42/89 45/90 631/337/470 64/60 692/699/1585/4 82/51 82/83 96/31 Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antineoplastic Agents - adverse effects Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Binding Sites Biomarkers - blood Biomarkers - metabolism Catalytic Domain Cell Line, Transformed Cell Line, Tumor Chemotherapy Cisplatin Cisplatin - adverse effects Cisplatin - antagonists & inhibitors Cisplatin - pharmacology Creatinine Electron microscopy Flavanones - chemistry Flavanones - metabolism Flavanones - pharmacology Flavanones - therapeutic use Hepatoma Humans Infiltration Inflammation Injuries Kidney - drug effects Kidney - immunology Kidney - metabolism Kidney - pathology Kidney Tubules - drug effects Kidney Tubules - immunology Kidney Tubules - metabolism Kidney Tubules - ultrastructure Kidneys Laboratory Medicine Macrophage Activation - drug effects Macrophages Male Medicine Medicine & Public Health Mice, Inbred C57BL Microscopy, Electron, Transmission Molecular docking Molecular Docking Simulation Necroptosis NF-κB protein Pathology Protective Agents - chemistry Protective Agents - metabolism Protective Agents - pharmacology Protective Agents - therapeutic use Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors Receptor-Interacting Protein Serine-Threonine Kinases - chemistry Receptor-Interacting Protein Serine-Threonine Kinases - metabolism research-article RNA Interference Rodents Therapy Urea
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