Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson’s Disease

The pathogenesis of Parkinson’s disease (PD) remains to be elucidated. Metabolomic analysis has the potential to identify biochemical pathways and metabolic profiles that are involved in PD pathogenesis. Here, we performed a targeted metabolomics to quantify the plasma levels of 184 metabolites in a...

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Veröffentlicht in:	Molecular neurobiology 2018-08, Vol.55 (8), p.6319-6328
Hauptverfasser:	Chang, Kuo-Hsuan, Cheng, Mei-Ling, Tang, Hsiang-Yu, Huang, Cheng-Yu, Wu, Yih-Ru, Chen, Chiung-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomedical and Life Sciences Biomedicine Cell Biology Cohort Studies Dementia disorders Dopamine Dyskinesia Female Humans Huntington's disease Kynurenic acid Kynurenine - metabolism Levodopa Male Metabolism Metabolites Metabolome Metabolomics Middle Aged Movement disorders Neurobiology Neurodegenerative diseases Neurology Neuroprotection Neurosciences Neurotoxicity Ornithine Parkinson Disease - blood Parkinson Disease - metabolism Parkinson's disease Pathogenesis Plasma levels Putrescine Quinolinic acid ROC Curve Tryptophan
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