Alcohol intake and T cell aging in HIV+ humans are associated with gut bacterial burden
Preclinical and clinical studies suggest that chronic alcohol consumption leads to gastrointestinal inflammation, in part, via alcohol-associated bacterial overgrowth and microbiota acetaldehyde production. TLFB total alcohol consumption (g) and AIT (cells/μL) were positively associated with stool 1...
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| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 2018-02, Vol.66, p.92-92 |
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| container_title | Alcohol (Fayetteville, N.Y.) |
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| creator | Maffei, V.J. Siggins, R.W. Luo, M. Molina, P. Taylor, C.M. Welsh, D.A. |
| description | Preclinical and clinical studies suggest that chronic alcohol consumption leads to gastrointestinal inflammation, in part, via alcohol-associated bacterial overgrowth and microbiota acetaldehyde production. TLFB total alcohol consumption (g) and AIT (cells/μL) were positively associated with stool 16S gene copy count (p = 0.04 & p = 0.04, respectively) after correction for clinical (age, BMI, sex, ART-compliance & CD4-count) and technical (homogenization batch & sequencing depth) confounding factors. [...]TLFB and AIT were positively associated with inferred KatG gene abundance (p = 0.04 & p = 0.03, respectively) after scaling KatG gene abundance by 16S gene copy count. |
| doi_str_mv | 10.1016/j.alcohol.2017.11.020 |
| format | Article |
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TLFB total alcohol consumption (g) and AIT (cells/μL) were positively associated with stool 16S gene copy count (p = 0.04 & p = 0.04, respectively) after correction for clinical (age, BMI, sex, ART-compliance & CD4-count) and technical (homogenization batch & sequencing depth) confounding factors. [...]TLFB and AIT were positively associated with inferred KatG gene abundance (p = 0.04 & p = 0.03, respectively) after scaling KatG gene abundance by 16S gene copy count.</abstract><cop>Philadelphia</cop><pub>Elsevier Inc</pub><doi>10.1016/j.alcohol.2017.11.020</doi><tpages>1</tpages></addata></record> |
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| subjects | Aging Alcohol use Alcoholic beverages Alcohols Bacteria HIV Human immunodeficiency virus Lymphocytes Lymphocytes T Microbiota Production capacity |
| title | Alcohol intake and T cell aging in HIV+ humans are associated with gut bacterial burden |
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