Tetrahydroaminoacridine–Lecithin Combination Treatment in Patients with Intermediate-Stage Alzheimer's Disease: Results of a Canadian Double-Blind, Crossover, Multicenter Study

We studied the efficacy and safety of oral tetrahydroaminoacridine (THA) combined with lecithin in 52 patients with Alzheimer's disease. The maximal tolerated dose of THA (up to 100 mg per day) was determined during an eight-week titration period, after which the tolerated dose of THA or placeb...

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Veröffentlicht in:	The New England journal of medicine 1990-05, Vol.322 (18), p.1272-1276
Hauptverfasser:	Gauthier, Louise, Gauthier, Serge, Bouchard, Rémi, Lamontagne, Albert, Bailey, Peter, Bergman, Howard, Ratner, Jack, Tesfaye, Yoseph, Saint-Martin, Monique, Bacher, Yves, Carrier, Louise, Charbonneau, Roland, Clarfield, A. Mark, Collier, Brian, Dastoor, Dolly, Germain, Marcel, Kissel, Catherine, Krieger, Monique, Kushnir, Seymour, Masson, Hélène, Morin, Jacques, Nair, Vasavan, Neirinck, Leonard, Suissa, Samy
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Aged, 80 and over Alanine Alanine transaminase Alzheimer Disease - drug therapy Alzheimer's disease Aminoacridines - administration & dosage Biological and medical sciences Biopsy Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - adverse effects Cholinesterase Inhibitors - therapeutic use Clinical trials Dementia Dementia disorders Double-Blind Method Drug dosages Drug Evaluation Drug Therapy, Combination Drug Tolerance Epidemiology Female Hepatocytes Hospitals Humans Intelligence Tests Lecithin Male Medical sciences Middle Aged Multicenter Studies as Topic Neurodegenerative diseases Neuropharmacology Patient Compliance Patients Pharmacology. Drug treatments Phosphatidylcholines - administration & dosage Phosphatidylcholines - adverse effects Phosphatidylcholines - therapeutic use Psychiatry Randomized Controlled Trials as Topic Tacrine - administration & dosage Tacrine - adverse effects Tacrine - therapeutic use Titration
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