NO ASSOCIATION BETWEEN A POLYMORPHISM IN THE PROMOTER REGION OF THE MAOA GENE WITH ANTISOCIAL PERSONALITY TRAITS IN ALCOHOLICS
— Aims: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. Methods: The repeat number (3–5) of the MAOA polymorp...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2003-01, Vol.38 (1), p.31-34 |
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| creator | Koller, G. Bondy, B. Preuss, U. W. Bottlender, M. Soyka, M. |
| description | — Aims: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. Methods: The repeat number (3–5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown–Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown–Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted. Results: High scores were found, i.e. 47.9% in Brown–Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. Conclusions: Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits. |
| doi_str_mv | 10.1093/alcalc/agg003 |
| format | Article |
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W. ; Bottlender, M. ; Soyka, M.</creator><creatorcontrib>Koller, G. ; Bondy, B. ; Preuss, U. W. ; Bottlender, M. ; Soyka, M.</creatorcontrib><description>— Aims: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. Methods: The repeat number (3–5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown–Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown–Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted. Results: High scores were found, i.e. 47.9% in Brown–Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. Conclusions: Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.</description><identifier>ISSN: 0735-0414</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agg003</identifier><identifier>PMID: 12554604</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; Alcoholism ; Alcoholism - enzymology ; Alcoholism - genetics ; Alcoholism - psychology ; Alleles ; Antisocial personality disorder ; Antisocial Personality Disorder - enzymology ; Antisocial Personality Disorder - genetics ; Antisocial Personality Disorder - psychology ; Biological and medical sciences ; Chromosomes, Human, X ; Dinucleotide Repeats - genetics ; Gene Expression Regulation, Enzymologic ; Genotype ; Humans ; Introns ; Medical sciences ; Middle Aged ; Minisatellite Repeats - genetics ; Monoamine Oxidase - genetics ; Personality Inventory ; Polymorphism, Genetic - genetics ; Promoter Regions, Genetic - genetics ; Psychology. 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Psychiatry</subject><ispartof>Alcohol and alcoholism (Oxford), 2003-01, Vol.38 (1), p.31-34</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jan 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-765a6e9f732807d044e6a39363abcd8077b0ca14f1d3386fccce29ad6ff6887e3</citedby><cites>FETCH-LOGICAL-c423t-765a6e9f732807d044e6a39363abcd8077b0ca14f1d3386fccce29ad6ff6887e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14531148$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12554604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koller, G.</creatorcontrib><creatorcontrib>Bondy, B.</creatorcontrib><creatorcontrib>Preuss, U. W.</creatorcontrib><creatorcontrib>Bottlender, M.</creatorcontrib><creatorcontrib>Soyka, M.</creatorcontrib><title>NO ASSOCIATION BETWEEN A POLYMORPHISM IN THE PROMOTER REGION OF THE MAOA GENE WITH ANTISOCIAL PERSONALITY TRAITS IN ALCOHOLICS</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol and Alcoholism</addtitle><description>— Aims: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. Methods: The repeat number (3–5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown–Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown–Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted. Results: High scores were found, i.e. 47.9% in Brown–Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. Conclusions: Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.</description><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcoholism</subject><subject>Alcoholism - enzymology</subject><subject>Alcoholism - genetics</subject><subject>Alcoholism - psychology</subject><subject>Alleles</subject><subject>Antisocial personality disorder</subject><subject>Antisocial Personality Disorder - enzymology</subject><subject>Antisocial Personality Disorder - genetics</subject><subject>Antisocial Personality Disorder - psychology</subject><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, X</subject><subject>Dinucleotide Repeats - genetics</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Genotype</subject><subject>Humans</subject><subject>Introns</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minisatellite Repeats - genetics</subject><subject>Monoamine Oxidase - genetics</subject><subject>Personality Inventory</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>0735-0414</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFFr2zAUhcXYWLNuj3sdYrBHr5IlS_ajZtRY4FjB1ujaF6HIcknXNp2VwPrS3z6nCQtcuHDud8-BA8BnjL5jVJALd--nuXC3twiRN2CGKaMJyVD6FswQJ1mCKKZn4EOMdwhhSlL8HpzhNMsoQ3QGXhoNRdfpUgmjdAN_SHMlZQMFXOr6eqHbZaW6BVQNNJWEy1YvtJEtbOV8T-vLV3khtIBz2Uh4pUwFRWPUq2MNl7LtdCNqZa6haYUy3d5K1KWudK3K7iN4N7j7GD4d9zn4eSlNWSW1nqtS1ImnKdkmnGWOhWLgJM0R7xGlgTlSEEbcyveTxFfIO0wH3BOSs8F7H9LC9WwYWJ7zQM7B14Pv07j5swtxa-82u_FxirS4yAnmGcITlBwgP25iHMNgn8b1gxufLUZ2X7Y9lG0PZU_8l6PpbvUQ-hN9bHcCvh0BF6fHYXSPfh1PHM0IxjQ_Ba_jNvz9f3fjb8s44Zmtft3YLi-rqi2NvSH_AB-rjaE</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Koller, G.</creator><creator>Bondy, B.</creator><creator>Preuss, U. W.</creator><creator>Bottlender, M.</creator><creator>Soyka, M.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope></search><sort><creationdate>200301</creationdate><title>NO ASSOCIATION BETWEEN A POLYMORPHISM IN THE PROMOTER REGION OF THE MAOA GENE WITH ANTISOCIAL PERSONALITY TRAITS IN ALCOHOLICS</title><author>Koller, G. ; Bondy, B. ; Preuss, U. W. ; Bottlender, M. ; Soyka, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-765a6e9f732807d044e6a39363abcd8077b0ca14f1d3386fccce29ad6ff6887e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Alcoholism</topic><topic>Alcoholism - enzymology</topic><topic>Alcoholism - genetics</topic><topic>Alcoholism - psychology</topic><topic>Alleles</topic><topic>Antisocial personality disorder</topic><topic>Antisocial Personality Disorder - enzymology</topic><topic>Antisocial Personality Disorder - genetics</topic><topic>Antisocial Personality Disorder - psychology</topic><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, X</topic><topic>Dinucleotide Repeats - genetics</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Genotype</topic><topic>Humans</topic><topic>Introns</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minisatellite Repeats - genetics</topic><topic>Monoamine Oxidase - genetics</topic><topic>Personality Inventory</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koller, G.</creatorcontrib><creatorcontrib>Bondy, B.</creatorcontrib><creatorcontrib>Preuss, U. W.</creatorcontrib><creatorcontrib>Bottlender, M.</creatorcontrib><creatorcontrib>Soyka, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koller, G.</au><au>Bondy, B.</au><au>Preuss, U. W.</au><au>Bottlender, M.</au><au>Soyka, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NO ASSOCIATION BETWEEN A POLYMORPHISM IN THE PROMOTER REGION OF THE MAOA GENE WITH ANTISOCIAL PERSONALITY TRAITS IN ALCOHOLICS</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol and Alcoholism</addtitle><date>2003-01</date><risdate>2003</risdate><volume>38</volume><issue>1</issue><spage>31</spage><epage>34</epage><pages>31-34</pages><issn>0735-0414</issn><eissn>1464-3502</eissn><abstract>— Aims: We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. Methods: The repeat number (3–5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown–Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown–Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted. Results: High scores were found, i.e. 47.9% in Brown–Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. Conclusions: Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12554604</pmid><doi>10.1093/alcalc/agg003</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alcohol and alcoholism (Oxford), 2003-01, Vol.38 (1), p.31-34 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Addictive behaviors Adult Adult and adolescent clinical studies Alcoholism Alcoholism - enzymology Alcoholism - genetics Alcoholism - psychology Alleles Antisocial personality disorder Antisocial Personality Disorder - enzymology Antisocial Personality Disorder - genetics Antisocial Personality Disorder - psychology Biological and medical sciences Chromosomes, Human, X Dinucleotide Repeats - genetics Gene Expression Regulation, Enzymologic Genotype Humans Introns Medical sciences Middle Aged Minisatellite Repeats - genetics Monoamine Oxidase - genetics Personality Inventory Polymorphism, Genetic - genetics Promoter Regions, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | NO ASSOCIATION BETWEEN A POLYMORPHISM IN THE PROMOTER REGION OF THE MAOA GENE WITH ANTISOCIAL PERSONALITY TRAITS IN ALCOHOLICS |
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