Ameliorative Effect of VE, IGF-I, and hCG on the Fluoride-Induced Testosterone Release Suppression in Mice Leydig Cells

Excessive consumption of fluoride (F) through drinking, eating, and/or environmental contaminants induces chronic toxicity known as fluorosis. Our previous research has shown that fluorosis was associated with male reproductive disorders. The current study is designed to explain the protective effec...

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Veröffentlicht in:Biological trace element research 2018, Vol.181 (1), p.95-103
Hauptverfasser: Yu, Yuxiang, Han, Yongli, Niu, Ruiyan, Wang, Jundong, Manthari, Ram Kumar, Ommati, Mohammad Mehdi, Sun, Zilong
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Sprache:eng
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Zusammenfassung:Excessive consumption of fluoride (F) through drinking, eating, and/or environmental contaminants induces chronic toxicity known as fluorosis. Our previous research has shown that fluorosis was associated with male reproductive disorders. The current study is designed to explain the protective effect of vitamin E (VE), insulin-like growth factor-I (IGF-I), and human chorionic gonadotropin (hCG) against natrium fluoride (NaF)-induced alterations in isolated Leydig cells (LCs). These NaF-induced alterations include decreased cell proliferation, steroidogenesis, and relative gene expression. Isolated LCs were incubated with NaF (0, 5, 20 mg/L) and/or 10 μg/ml VE, 100 ng/ml IGF-I, and 100 IU/ml hCG. NaF-treated cells’ ability to secrete testosterone (T) was significantly less than other treated groups ( P  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-017-1023-1