Grafting of thermo- and pH-responsive polymer inside mesoporous silica foam in supercritical carbon dioxide for controlled release of 5-fluorouracil
Mesocellular silica foam (MCF) grafted with thermo-responsive and pH-responsive copolymer poly( N -isopropylacrylamide- co -acrylic acid), was prepared by precipitation polymerization using supercritical carbon dioxide (scCO 2 ) as entrainer and solvent. Vinyl-functionalized MCF was first synthesize...
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| Veröffentlicht in: | Fibers and polymers 2017-12, Vol.18 (12), p.2476-2480 |
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| container_title | Fibers and polymers |
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| creator | Hao, Youwei Zhao, Jie Wang, Gang Cao, Liqin Wang, Jide Yue, Fan |
| description | Mesocellular silica foam (MCF) grafted with thermo-responsive and pH-responsive copolymer poly(
N
-isopropylacrylamide-
co
-acrylic acid), was prepared by precipitation polymerization using supercritical carbon dioxide (scCO
2
) as entrainer and solvent. Vinyl-functionalized MCF was first synthesized through post-synthesis via using vinyltriethoxysilane as a coupling agent for surface modification. Entrapped monomers of N-isopropylacrylamide (NIPA) and acrylic acid (AA) were then introduced and assembled onto the vinyl-modified MCF with the aid of scCO
2
. The grafting copolymer performed here as an on/off switch in the release of 5-fluorouracil, as confirmed by using UV-visible absorption spectroscopy. The grafted organic content and drug loading efficiency were 65.2 wt% and 11.5 wt%, respectively. The resultant grafting composite showed potential for application in drug delivery and exhibited thermo- and pH-responsiveness to external environmental changes. |
| doi_str_mv | 10.1007/s12221-017-7446-7 |
| format | Article |
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N
-isopropylacrylamide-
co
-acrylic acid), was prepared by precipitation polymerization using supercritical carbon dioxide (scCO
2
) as entrainer and solvent. Vinyl-functionalized MCF was first synthesized through post-synthesis via using vinyltriethoxysilane as a coupling agent for surface modification. Entrapped monomers of N-isopropylacrylamide (NIPA) and acrylic acid (AA) were then introduced and assembled onto the vinyl-modified MCF with the aid of scCO
2
. The grafting copolymer performed here as an on/off switch in the release of 5-fluorouracil, as confirmed by using UV-visible absorption spectroscopy. The grafted organic content and drug loading efficiency were 65.2 wt% and 11.5 wt%, respectively. The resultant grafting composite showed potential for application in drug delivery and exhibited thermo- and pH-responsiveness to external environmental changes.</description><identifier>ISSN: 1229-9197</identifier><identifier>EISSN: 1875-0052</identifier><identifier>DOI: 10.1007/s12221-017-7446-7</identifier><language>eng</language><publisher>Seoul: The Korean Fiber Society</publisher><subject>Acrylic acid ; Acrylics ; Carbon dioxide ; Carbon monoxide ; Chemistry ; Chemistry and Materials Science ; Communication ; Controlled release ; Coupling agents ; Drug delivery systems ; Graft copolymers ; Isopropylacrylamide ; Polymer Sciences ; Silicon dioxide</subject><ispartof>Fibers and polymers, 2017-12, Vol.18 (12), p.2476-2480</ispartof><rights>The Korean Fiber Society and Springer Science+Business Media B.V., part of Springer Nature 2017</rights><rights>Copyright Springer Science & Business Media Dec 2017</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-26ba8b3525f8b09418e2ccca883a26cd33df65b6b6ae63bb2957413286d893403</citedby><cites>FETCH-LOGICAL-c316t-26ba8b3525f8b09418e2ccca883a26cd33df65b6b6ae63bb2957413286d893403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12221-017-7446-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12221-017-7446-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Hao, Youwei</creatorcontrib><creatorcontrib>Zhao, Jie</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><creatorcontrib>Cao, Liqin</creatorcontrib><creatorcontrib>Wang, Jide</creatorcontrib><creatorcontrib>Yue, Fan</creatorcontrib><title>Grafting of thermo- and pH-responsive polymer inside mesoporous silica foam in supercritical carbon dioxide for controlled release of 5-fluorouracil</title><title>Fibers and polymers</title><addtitle>Fibers Polym</addtitle><description>Mesocellular silica foam (MCF) grafted with thermo-responsive and pH-responsive copolymer poly(
N
-isopropylacrylamide-
co
-acrylic acid), was prepared by precipitation polymerization using supercritical carbon dioxide (scCO
2
) as entrainer and solvent. Vinyl-functionalized MCF was first synthesized through post-synthesis via using vinyltriethoxysilane as a coupling agent for surface modification. Entrapped monomers of N-isopropylacrylamide (NIPA) and acrylic acid (AA) were then introduced and assembled onto the vinyl-modified MCF with the aid of scCO
2
. The grafting copolymer performed here as an on/off switch in the release of 5-fluorouracil, as confirmed by using UV-visible absorption spectroscopy. The grafted organic content and drug loading efficiency were 65.2 wt% and 11.5 wt%, respectively. The resultant grafting composite showed potential for application in drug delivery and exhibited thermo- and pH-responsiveness to external environmental changes.</description><subject>Acrylic acid</subject><subject>Acrylics</subject><subject>Carbon dioxide</subject><subject>Carbon monoxide</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Communication</subject><subject>Controlled release</subject><subject>Coupling agents</subject><subject>Drug delivery systems</subject><subject>Graft copolymers</subject><subject>Isopropylacrylamide</subject><subject>Polymer Sciences</subject><subject>Silicon dioxide</subject><issn>1229-9197</issn><issn>1875-0052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1UMtq3DAUNSGFTtJ8QHeCrNXqYUvyMgxtEgh0k6yFLF8lGmTLufKUzn_0gyszXXTT1X2dx-U0zWfOvnDG9NfChRCcMq6pbltF9UWz40Z3lLFOXNZeiJ72vNcfm6tSDowpLrTcNb_v0YU1zq8kB7K-AU6ZEjePZHmgCGXJc4k_gSw5nSZAEus4Apmg5CVjPhZSYorekZDdVK-kHBdAj3Gty0S8wyHPZIz510YLGYnP84o5JRgJQgJXYHPuaEjHTRCdj-lT8yG4VODmb71uXr5_e94_0Kcf94_7uyfqJVcrFWpwZpCd6IIZWN9yA8J774yRTig_SjkG1Q1qUA6UHAbRd7rlUhg1ml62TF43t2fdBfP7EcpqD_WDuVpa3hteMZ3uK4qfUR5zKQjBLhgnhyfLmd3Ct-fwbQ3fbuFbXTnizCkVO78C_qP8X9IfmE-KCA</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Hao, Youwei</creator><creator>Zhao, Jie</creator><creator>Wang, Gang</creator><creator>Cao, Liqin</creator><creator>Wang, Jide</creator><creator>Yue, Fan</creator><general>The Korean Fiber Society</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20171201</creationdate><title>Grafting of thermo- and pH-responsive polymer inside mesoporous silica foam in supercritical carbon dioxide for controlled release of 5-fluorouracil</title><author>Hao, Youwei ; Zhao, Jie ; Wang, Gang ; Cao, Liqin ; Wang, Jide ; Yue, Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-26ba8b3525f8b09418e2ccca883a26cd33df65b6b6ae63bb2957413286d893403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acrylic acid</topic><topic>Acrylics</topic><topic>Carbon dioxide</topic><topic>Carbon monoxide</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Communication</topic><topic>Controlled release</topic><topic>Coupling agents</topic><topic>Drug delivery systems</topic><topic>Graft copolymers</topic><topic>Isopropylacrylamide</topic><topic>Polymer Sciences</topic><topic>Silicon dioxide</topic><toplevel>online_resources</toplevel><creatorcontrib>Hao, Youwei</creatorcontrib><creatorcontrib>Zhao, Jie</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><creatorcontrib>Cao, Liqin</creatorcontrib><creatorcontrib>Wang, Jide</creatorcontrib><creatorcontrib>Yue, Fan</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Fibers and polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Youwei</au><au>Zhao, Jie</au><au>Wang, Gang</au><au>Cao, Liqin</au><au>Wang, Jide</au><au>Yue, Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grafting of thermo- and pH-responsive polymer inside mesoporous silica foam in supercritical carbon dioxide for controlled release of 5-fluorouracil</atitle><jtitle>Fibers and polymers</jtitle><stitle>Fibers Polym</stitle><date>2017-12-01</date><risdate>2017</risdate><volume>18</volume><issue>12</issue><spage>2476</spage><epage>2480</epage><pages>2476-2480</pages><issn>1229-9197</issn><eissn>1875-0052</eissn><abstract>Mesocellular silica foam (MCF) grafted with thermo-responsive and pH-responsive copolymer poly(
N
-isopropylacrylamide-
co
-acrylic acid), was prepared by precipitation polymerization using supercritical carbon dioxide (scCO
2
) as entrainer and solvent. Vinyl-functionalized MCF was first synthesized through post-synthesis via using vinyltriethoxysilane as a coupling agent for surface modification. Entrapped monomers of N-isopropylacrylamide (NIPA) and acrylic acid (AA) were then introduced and assembled onto the vinyl-modified MCF with the aid of scCO
2
. The grafting copolymer performed here as an on/off switch in the release of 5-fluorouracil, as confirmed by using UV-visible absorption spectroscopy. The grafted organic content and drug loading efficiency were 65.2 wt% and 11.5 wt%, respectively. The resultant grafting composite showed potential for application in drug delivery and exhibited thermo- and pH-responsiveness to external environmental changes.</abstract><cop>Seoul</cop><pub>The Korean Fiber Society</pub><doi>10.1007/s12221-017-7446-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | Fibers and polymers, 2017-12, Vol.18 (12), p.2476-2480 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Acrylic acid Acrylics Carbon dioxide Carbon monoxide Chemistry Chemistry and Materials Science Communication Controlled release Coupling agents Drug delivery systems Graft copolymers Isopropylacrylamide Polymer Sciences Silicon dioxide |
| title | Grafting of thermo- and pH-responsive polymer inside mesoporous silica foam in supercritical carbon dioxide for controlled release of 5-fluorouracil |
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