Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1a Pathway

Skeletal muscle insulin resistance is the hallmark of type 2 diabetes and develops long before the onset of the disease. It is well accepted that physical activity improves glycemic control, but the knowledge on underlying mechanisms mediating the beneficial effects remains incomplete. Exercise is a...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2017-11, Vol.66 (11), p.2800
Hauptverfasser:	Görgens, Sven W, Benninghoff, Tim, Eckardt, Kristin, Springer, Christian, Chadt, Alexandra, Melior, Anita, Wefers, Jakob, Cramer, Andrea, Jensen, Jørgen, Birkeland, Kåre I, Drevon, Christian A, Al-Hasani, Hadi, Eckel, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell surface Diabetes Diabetes mellitus Gene expression Genomes Glucose Glucose metabolism Glucose monitoring Hypoxia Hypoxia-inducible factor 1a Insulin Insulin resistance Medical research Metabolism Muscle contraction Physical activity Physical training Skeletal muscle Transcription
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