Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery
Although gas-filled microbubbles with high echogenicity are widely applied inclinical ultrasonography, the micron scale particle size impedes their use in the treatment of solid tumors,which are accessible to objects less than several hundred nanometers. We herein propose an unusual approach involvi...
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| Veröffentlicht in: | Nano research 2018-07, Vol.11 (7), p.3710-3721 |
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| container_title | Nano research |
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| creator | Wang, Yiru Yin, Tinghui Su, Zhenwei Qiu, Chen Wang, Yong Zheng, Rongqin Chen, Meiwan Shuai, Xintao |
| description | Although gas-filled microbubbles with high echogenicity are widely applied inclinical ultrasonography, the micron scale particle size impedes their use in the treatment of solid tumors,which are accessible to objects less than several hundred nanometers. We herein propose an unusual approach involving apH-induced core–shell micelle-to-vesicle transition to prepare ultrasound-sensitive polymeric nanospheres (polymersomes in structure) possessing multiple features, including nanosize, monodispersity, and incorporation of a phase-transitional imaging agent into the aqueous lumen. These features are not achievable via the conventional double-emulsion method for polymersome preparation. The nanospheres were constructed based on a novel triblock copolymer with dual pH sensitivity. The liquid-to-gas phase transition of the imaging agent induced by external low-frequency ultrasound may destroy the nanospheres for a rapid drug release, with simultaneous tissue-penetrating drug delivery inside a tumor. These effects may provide new opportunities for the development of an effective cancer therapy with few adverse effects. |
| doi_str_mv | 10.1007/s12274-017-1939-y |
| format | Article |
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We herein propose an unusual approach involving apH-induced core–shell micelle-to-vesicle transition to prepare ultrasound-sensitive polymeric nanospheres (polymersomes in structure) possessing multiple features, including nanosize, monodispersity, and incorporation of a phase-transitional imaging agent into the aqueous lumen. These features are not achievable via the conventional double-emulsion method for polymersome preparation. The nanospheres were constructed based on a novel triblock copolymer with dual pH sensitivity. The liquid-to-gas phase transition of the imaging agent induced by external low-frequency ultrasound may destroy the nanospheres for a rapid drug release, with simultaneous tissue-penetrating drug delivery inside a tumor. These effects may provide new opportunities for the development of an effective cancer therapy with few adverse effects.</description><identifier>ISSN: 1998-0124</identifier><identifier>EISSN: 1998-0000</identifier><identifier>DOI: 10.1007/s12274-017-1939-y</identifier><language>eng</language><publisher>Beijing: Tsinghua University Press</publisher><subject>Atomic/Molecular Structure and Spectra ; Biomedicine ; Biotechnology ; Block copolymers ; Cancer ; Chemistry and Materials Science ; Condensed Matter Physics ; Drug delivery ; Drug delivery systems ; Materials Science ; Micelles ; Nanospheres ; Nanotechnology ; pH effects ; Phase transitions ; Research Article ; Solid tumors ; Ultrasonic imaging ; Ultrasound</subject><ispartof>Nano research, 2018-07, Vol.11 (7), p.3710-3721</ispartof><rights>Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2017</rights><rights>Nano Research is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-aa56936cb5a9c8243c87a055771437e29e1b3bcba062bd6bb3246dbfc1d2e2f33</citedby><cites>FETCH-LOGICAL-c316t-aa56936cb5a9c8243c87a055771437e29e1b3bcba062bd6bb3246dbfc1d2e2f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12274-017-1939-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12274-017-1939-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Wang, Yiru</creatorcontrib><creatorcontrib>Yin, Tinghui</creatorcontrib><creatorcontrib>Su, Zhenwei</creatorcontrib><creatorcontrib>Qiu, Chen</creatorcontrib><creatorcontrib>Wang, Yong</creatorcontrib><creatorcontrib>Zheng, Rongqin</creatorcontrib><creatorcontrib>Chen, Meiwan</creatorcontrib><creatorcontrib>Shuai, Xintao</creatorcontrib><title>Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery</title><title>Nano research</title><addtitle>Nano Res</addtitle><description>Although gas-filled microbubbles with high echogenicity are widely applied inclinical ultrasonography, the micron scale particle size impedes their use in the treatment of solid tumors,which are accessible to objects less than several hundred nanometers. 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We herein propose an unusual approach involving apH-induced core–shell micelle-to-vesicle transition to prepare ultrasound-sensitive polymeric nanospheres (polymersomes in structure) possessing multiple features, including nanosize, monodispersity, and incorporation of a phase-transitional imaging agent into the aqueous lumen. These features are not achievable via the conventional double-emulsion method for polymersome preparation. The nanospheres were constructed based on a novel triblock copolymer with dual pH sensitivity. The liquid-to-gas phase transition of the imaging agent induced by external low-frequency ultrasound may destroy the nanospheres for a rapid drug release, with simultaneous tissue-penetrating drug delivery inside a tumor. 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| fulltext | fulltext |
| identifier | ISSN: 1998-0124 |
| ispartof | Nano research, 2018-07, Vol.11 (7), p.3710-3721 |
| issn | 1998-0124 1998-0000 |
| language | eng |
| recordid | cdi_proquest_journals_1980858167 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Atomic/Molecular Structure and Spectra Biomedicine Biotechnology Block copolymers Cancer Chemistry and Materials Science Condensed Matter Physics Drug delivery Drug delivery systems Materials Science Micelles Nanospheres Nanotechnology pH effects Phase transitions Research Article Solid tumors Ultrasonic imaging Ultrasound |
| title | Highly uniform ultrasound-sensitive nanospheres produced by a pH-induced micelle-to-vesicle transition for tumor-targeted drug delivery |
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