Molecular and structural analysis via hydrodynamic methods: Cationic poly(2-aminoethyl-methacrylate)s
Pharmaceutically relevant cationic linear poly(2-aminoethyl-methacrylate)s were synthesized by reversible addition-fragmentation chain transfer polymerization resulting in a homologous series of the homopolymers in a wide range of molar masses (10,000
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| Veröffentlicht in: | Polymer (Guilford) 2017-11, Vol.131, p.252-262 |
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| creator | Perevyazko, Igor Trützschler, Anne-K. Gubarev, Alexander Lebedeva, Elena Traeger, Anja Schubert, Ulrich S. Tsvetkov, Nikolay |
| description | Pharmaceutically relevant cationic linear poly(2-aminoethyl-methacrylate)s were synthesized by reversible addition-fragmentation chain transfer polymerization resulting in a homologous series of the homopolymers in a wide range of molar masses (10,000 |
| doi_str_mv | 10.1016/j.polymer.2017.10.032 |
| format | Article |
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[Display omitted]
•Combination of hydrodynamic and optical methods is used to study cationic polymers.•The absolute molar masses are determined by AUC and AF4 techniques.•The influence of the polymer α-end group on the solvation properties is shown.•The conformation is established via the scaling relationships.•The conformational characteristics are determined for different solvent systems.</description><identifier>ISSN: 0032-3861</identifier><identifier>EISSN: 1873-2291</identifier><identifier>DOI: 10.1016/j.polymer.2017.10.032</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Addition polymerization ; Analytical ultracentrifugation ; Anisotropy ; Asymmetric flow field-flow fractionation ; Birefringence ; Cationic polymers ; Cations ; Chain transfer ; Chains (polymeric) ; Characterization ; Chemical compounds ; Chemical synthesis ; Coils ; Conformation ; Diffusion ; Fluid mechanics ; Fractionation ; Homology ; Macromolecules ; Optics ; Polarizability ; Poly(2-aminoethyl-methacrylate) ; Polymerization ; Polymers ; Random coil ; Rigidity ; Scaling ; Sedimentation ; Sodium chloride ; Solution properties ; Solvation ; Structural analysis ; Ultracentrifugation ; Viscosity</subject><ispartof>Polymer (Guilford), 2017-11, Vol.131, p.252-262</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright Elsevier BV Nov 22, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-ea75f4e29c88ad87987178de94bd29d5582161cbb9a8f85d17012354765d968a3</citedby><cites>FETCH-LOGICAL-c289t-ea75f4e29c88ad87987178de94bd29d5582161cbb9a8f85d17012354765d968a3</cites><orcidid>0000-0003-4978-4670</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.polymer.2017.10.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids></links><search><creatorcontrib>Perevyazko, Igor</creatorcontrib><creatorcontrib>Trützschler, Anne-K.</creatorcontrib><creatorcontrib>Gubarev, Alexander</creatorcontrib><creatorcontrib>Lebedeva, Elena</creatorcontrib><creatorcontrib>Traeger, Anja</creatorcontrib><creatorcontrib>Schubert, Ulrich S.</creatorcontrib><creatorcontrib>Tsvetkov, Nikolay</creatorcontrib><title>Molecular and structural analysis via hydrodynamic methods: Cationic poly(2-aminoethyl-methacrylate)s</title><title>Polymer (Guilford)</title><description>Pharmaceutically relevant cationic linear poly(2-aminoethyl-methacrylate)s were synthesized by reversible addition-fragmentation chain transfer polymerization resulting in a homologous series of the homopolymers in a wide range of molar masses (10,000<M<130,000gmol−1) and relatively narrow dispersities (Ð:1.3±0.4). The polymers were studied in 0.2MNaCl and 0.2MNaOH in water, applying combined analytical approach comprising of complementary hydrodynamic and optical methods such as analytical ultracentrifugation, intrinsic viscosity, translation diffusion, flow birefringence and asymmetric flow field-flow fractionation (AF4) as well as standard characterization technique (SEC). The efforts were focused on the evaluation of solution (solvation), molecular (absolute molar masses), conformational (equilibrium rigidity, diameter of the polymer chain) and optical (anisotropy of optical polarizability of the monomer unit) characteristics of the polymers. Consequently the absolute values of the molar masses were determined by the sedimentation-diffusion analysis and AF4 resulting in well consistent results. The corresponding scaling relationships in 0.2MNaCl water ([η]=0.0031×M0.83; s0=0.0324×M0.39; D0=3,909×M−0.64) show linear trends in whole range of molar masses revealing random coil conformation of the macromolecules. Conformational characteristics were determined in 0.2MNaCl (equilibrium rigidity A=5.3±1.5nm) and 0.2MNaOH (A=1.3±0.1nm) revealing an influence of uncompensated charges on the polymer conformation.
[Display omitted]
•Combination of hydrodynamic and optical methods is used to study cationic polymers.•The absolute molar masses are determined by AUC and AF4 techniques.•The influence of the polymer α-end group on the solvation properties is shown.•The conformation is established via the scaling relationships.•The conformational characteristics are determined for different solvent systems.</description><subject>Addition polymerization</subject><subject>Analytical ultracentrifugation</subject><subject>Anisotropy</subject><subject>Asymmetric flow field-flow fractionation</subject><subject>Birefringence</subject><subject>Cationic polymers</subject><subject>Cations</subject><subject>Chain transfer</subject><subject>Chains (polymeric)</subject><subject>Characterization</subject><subject>Chemical compounds</subject><subject>Chemical synthesis</subject><subject>Coils</subject><subject>Conformation</subject><subject>Diffusion</subject><subject>Fluid mechanics</subject><subject>Fractionation</subject><subject>Homology</subject><subject>Macromolecules</subject><subject>Optics</subject><subject>Polarizability</subject><subject>Poly(2-aminoethyl-methacrylate)</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Random coil</subject><subject>Rigidity</subject><subject>Scaling</subject><subject>Sedimentation</subject><subject>Sodium chloride</subject><subject>Solution properties</subject><subject>Solvation</subject><subject>Structural analysis</subject><subject>Ultracentrifugation</subject><subject>Viscosity</subject><issn>0032-3861</issn><issn>1873-2291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFUMtKxDAUDaLgOPoJQsGNLjomadMkbkQGXzDiRtchk6RMStqMSSr0702Z2bu63PO4l3MAuEZwhSBq7rvV3rupN2GFIaIZW8EKn4AFYrQqMeboFCxghsqKNegcXMTYQQgxwfUCmA_vjBqdDIUcdBFTGFUag3R5lW6KNha_Vha7SQevp0H2VhW9STuv40Oxlsn6ISPz_1tcZnbwmZxcOWukCpOTydzFS3DWShfN1XEuwffL89f6rdx8vr6vnzalwoyn0khK2tpgrhiTmlHOKKJMG15vNeaaEIZRg9R2yyVrGdGIQoQrUtOGaN4wWS3BzeHuPvif0cQkOj-GHCQKxBmkmNSYZxU5qFTwMQbTin2wvQyTQFDMjYpOHBsVc6MznOvLvseDz-QIvzazUVkzKKNtMCoJ7e0_F_4ApHSDSg</recordid><startdate>20171122</startdate><enddate>20171122</enddate><creator>Perevyazko, Igor</creator><creator>Trützschler, Anne-K.</creator><creator>Gubarev, Alexander</creator><creator>Lebedeva, Elena</creator><creator>Traeger, Anja</creator><creator>Schubert, Ulrich S.</creator><creator>Tsvetkov, Nikolay</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-4978-4670</orcidid></search><sort><creationdate>20171122</creationdate><title>Molecular and structural analysis via hydrodynamic methods: Cationic poly(2-aminoethyl-methacrylate)s</title><author>Perevyazko, Igor ; 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The polymers were studied in 0.2MNaCl and 0.2MNaOH in water, applying combined analytical approach comprising of complementary hydrodynamic and optical methods such as analytical ultracentrifugation, intrinsic viscosity, translation diffusion, flow birefringence and asymmetric flow field-flow fractionation (AF4) as well as standard characterization technique (SEC). The efforts were focused on the evaluation of solution (solvation), molecular (absolute molar masses), conformational (equilibrium rigidity, diameter of the polymer chain) and optical (anisotropy of optical polarizability of the monomer unit) characteristics of the polymers. Consequently the absolute values of the molar masses were determined by the sedimentation-diffusion analysis and AF4 resulting in well consistent results. The corresponding scaling relationships in 0.2MNaCl water ([η]=0.0031×M0.83; s0=0.0324×M0.39; D0=3,909×M−0.64) show linear trends in whole range of molar masses revealing random coil conformation of the macromolecules. Conformational characteristics were determined in 0.2MNaCl (equilibrium rigidity A=5.3±1.5nm) and 0.2MNaOH (A=1.3±0.1nm) revealing an influence of uncompensated charges on the polymer conformation.
[Display omitted]
•Combination of hydrodynamic and optical methods is used to study cationic polymers.•The absolute molar masses are determined by AUC and AF4 techniques.•The influence of the polymer α-end group on the solvation properties is shown.•The conformation is established via the scaling relationships.•The conformational characteristics are determined for different solvent systems.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.polymer.2017.10.032</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4978-4670</orcidid></addata></record> |
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| ispartof | Polymer (Guilford), 2017-11, Vol.131, p.252-262 |
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| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Addition polymerization Analytical ultracentrifugation Anisotropy Asymmetric flow field-flow fractionation Birefringence Cationic polymers Cations Chain transfer Chains (polymeric) Characterization Chemical compounds Chemical synthesis Coils Conformation Diffusion Fluid mechanics Fractionation Homology Macromolecules Optics Polarizability Poly(2-aminoethyl-methacrylate) Polymerization Polymers Random coil Rigidity Scaling Sedimentation Sodium chloride Solution properties Solvation Structural analysis Ultracentrifugation Viscosity |
| title | Molecular and structural analysis via hydrodynamic methods: Cationic poly(2-aminoethyl-methacrylate)s |
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