Expression signatures and roles of Micro RNA s in human oesophageal adenocarcinomas
The most common forms of oesophageal cancers are adenocarcinomas and squamous cell carcinoma ( SCC ). Although the incidence of SCC in the United States tends to be declining, the adenocarcinoma incidence caused by Barrett's oesophagus has been increasing. Oesophageal cancer is regarded as one...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2018-01, Vol.22 (1), p.123-130 |
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| creator | Kong, Xiangyi Gong, Shun Su, Lijuan Li, Chen Kong, Yanguo |
| description | The most common forms of oesophageal cancers are adenocarcinomas and squamous cell carcinoma (
SCC
). Although the incidence of
SCC
in the United States tends to be declining, the adenocarcinoma incidence caused by Barrett's oesophagus has been increasing. Oesophageal cancer is regarded as one of the most fatal malignancies with a short prognosis. Systemic manifestations of patients with
PCNSL
keep backward in spite of recent development of chemoradiotherapy. Micro
RNA
s are small non‐coding
RNA
s that can post‐transcriptionally down‐regulate the expression of genes by targeting
mRNA
s, causing their translational repression as well as degradation. Micro
RNA
s exert critical functions in many malignancy‐related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. Many deregulated mi
RNA
s have been identified in oesophageal adenocarcinomas, but their biological importance has not yet been fully elucidated. In this study, we review present evidence regarding the potential applications of oesophageal adenocarcinomas associated micro
RNA
s for prognosis and diagnosis of this lethal disease. |
| doi_str_mv | 10.1111/jcmm.13300 |
| format | Article |
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SCC
). Although the incidence of
SCC
in the United States tends to be declining, the adenocarcinoma incidence caused by Barrett's oesophagus has been increasing. Oesophageal cancer is regarded as one of the most fatal malignancies with a short prognosis. Systemic manifestations of patients with
PCNSL
keep backward in spite of recent development of chemoradiotherapy. Micro
RNA
s are small non‐coding
RNA
s that can post‐transcriptionally down‐regulate the expression of genes by targeting
mRNA
s, causing their translational repression as well as degradation. Micro
RNA
s exert critical functions in many malignancy‐related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. Many deregulated mi
RNA
s have been identified in oesophageal adenocarcinomas, but their biological importance has not yet been fully elucidated. In this study, we review present evidence regarding the potential applications of oesophageal adenocarcinomas associated micro
RNA
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SCC
). Although the incidence of
SCC
in the United States tends to be declining, the adenocarcinoma incidence caused by Barrett's oesophagus has been increasing. Oesophageal cancer is regarded as one of the most fatal malignancies with a short prognosis. Systemic manifestations of patients with
PCNSL
keep backward in spite of recent development of chemoradiotherapy. Micro
RNA
s are small non‐coding
RNA
s that can post‐transcriptionally down‐regulate the expression of genes by targeting
mRNA
s, causing their translational repression as well as degradation. Micro
RNA
s exert critical functions in many malignancy‐related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. Many deregulated mi
RNA
s have been identified in oesophageal adenocarcinomas, but their biological importance has not yet been fully elucidated. In this study, we review present evidence regarding the potential applications of oesophageal adenocarcinomas associated micro
RNA
s for prognosis and diagnosis of this lethal disease.</description><subject>Adenocarcinoma</subject><subject>Apoptosis</subject><subject>Barrett's esophagus</subject><subject>Chemoradiotherapy</subject><subject>Esophageal cancer</subject><subject>Incidence</subject><subject>Malignancy</subject><subject>Metabolism</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Post-transcription</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNotkFtLAzEQhYMoWKsv_oKAb8LWXLubx1JqFaqCl-cwZCftlm6yJl3Qf-_Wdl7mDBzOcD5Cbjmb8GEetq5tJ1xKxs7IiOtKFMpIdX7SvJLVJbnKecuYnHJpRuRj8dMlzLmJgeZmHWDfDyeFUNMUd4OKnr40LkX6_jqjmTaBbvoWAo2YY7eBNcKOQo0hOkiuCbGFfE0uPOwy3pz2mHw9Lj7nT8Xqbfk8n60Kx5lSBRjGp1ojr0uQTHlkClXNhDTcGxTaiFJ7QIQaXFly7Y0RWgF6h6pEL-WY3B1zuxS_e8x7u419CsNLy03FlJkKoQbX_dE1lMg5obddalpIv5Yze4BmD9DsPzT5B5l8X70</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Kong, Xiangyi</creator><creator>Gong, Shun</creator><creator>Su, Lijuan</creator><creator>Li, Chen</creator><creator>Kong, Yanguo</creator><general>John Wiley & Sons, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-8209-042X</orcidid></search><sort><creationdate>201801</creationdate><title>Expression signatures and roles of Micro RNA s in human oesophageal adenocarcinomas</title><author>Kong, Xiangyi ; Gong, Shun ; Su, Lijuan ; Li, Chen ; Kong, Yanguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1044-a901655e1d7a304fe04e4d02391f9e259275faeeadac7715f99254aefce47ef33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma</topic><topic>Apoptosis</topic><topic>Barrett's esophagus</topic><topic>Chemoradiotherapy</topic><topic>Esophageal cancer</topic><topic>Incidence</topic><topic>Malignancy</topic><topic>Metabolism</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Post-transcription</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Xiangyi</creatorcontrib><creatorcontrib>Gong, Shun</creatorcontrib><creatorcontrib>Su, Lijuan</creatorcontrib><creatorcontrib>Li, Chen</creatorcontrib><creatorcontrib>Kong, Yanguo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Xiangyi</au><au>Gong, Shun</au><au>Su, Lijuan</au><au>Li, Chen</au><au>Kong, Yanguo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression signatures and roles of Micro RNA s in human oesophageal adenocarcinomas</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><date>2018-01</date><risdate>2018</risdate><volume>22</volume><issue>1</issue><spage>123</spage><epage>130</epage><pages>123-130</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>The most common forms of oesophageal cancers are adenocarcinomas and squamous cell carcinoma (
SCC
). Although the incidence of
SCC
in the United States tends to be declining, the adenocarcinoma incidence caused by Barrett's oesophagus has been increasing. Oesophageal cancer is regarded as one of the most fatal malignancies with a short prognosis. Systemic manifestations of patients with
PCNSL
keep backward in spite of recent development of chemoradiotherapy. Micro
RNA
s are small non‐coding
RNA
s that can post‐transcriptionally down‐regulate the expression of genes by targeting
mRNA
s, causing their translational repression as well as degradation. Micro
RNA
s exert critical functions in many malignancy‐related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. Many deregulated mi
RNA
s have been identified in oesophageal adenocarcinomas, but their biological importance has not yet been fully elucidated. In this study, we review present evidence regarding the potential applications of oesophageal adenocarcinomas associated micro
RNA
s for prognosis and diagnosis of this lethal disease.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1111/jcmm.13300</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8209-042X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1582-1838 |
| ispartof | Journal of cellular and molecular medicine, 2018-01, Vol.22 (1), p.123-130 |
| issn | 1582-1838 1582-4934 |
| language | eng |
| recordid | cdi_proquest_journals_1980496224 |
| source | DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library Open Access; PubMed Central |
| subjects | Adenocarcinoma Apoptosis Barrett's esophagus Chemoradiotherapy Esophageal cancer Incidence Malignancy Metabolism MicroRNAs miRNA Post-transcription Prognosis Squamous cell carcinoma |
| title | Expression signatures and roles of Micro RNA s in human oesophageal adenocarcinomas |
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