Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF‐1α signaling

Angiogenesis of liver sinusoidal endothelial cells (LSECs) accompanies with hypoxia in liver fibrosis and they are of mutual promotion, which has raised wide concern. Here we established murine model of liver fibrosis and found that oroxylin A (40 mg/kg) could ameliorate angiogenesis in liver fibros...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-02, Vol.119 (2), p.2258-2268
Hauptverfasser:	Zhang, Chenxi, Bian, Mianli, Chen, Xingran, Jin, Huanhuan, Zhao, Shifeng, Yang, Xiang, Shao, Jiangjuan, Chen, Anping, Guo, Qinglong, Zhang, Feng, Zheng, Shizhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acriflavine Adaptor Proteins, Signal Transducing - metabolism Angiogenesis Angiopoietin Angiopoietin-2 - genetics Angiopoietin-2 - metabolism Animal models Animals Carbon Tetrachloride - toxicity CD31 antigen Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Cycle Proteins Cells, Cultured Disease Models, Animal Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Fibrosis Flavonoids - administration & dosage Flavonoids - pharmacology Gene Expression Regulation - drug effects Hepatocytes HIF‐1α Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Liver Liver Cirrhosis - chemically induced Liver Cirrhosis - drug therapy Liver Cirrhosis - genetics Liver Cirrhosis - metabolism liver fibrosis Male Mice Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - prevention & control Nuclear transport oroxylin A Phosphoproteins - metabolism Signal Transduction - drug effects Signaling Transcription Translocation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism YAP Yes-associated protein
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