Long non-coding RNA MEG3 inhibits cell growth of gliomas by targeting miR-93 and inactivating PI3K/AKT pathway

Gliomas are the most common cancers in the brain, accompanied with high morbility, occurrence, disability and mortality. Long non-coding RNAs (lncRNAs) have been proposed as promoter or inhibitor in many cancer processes. Previous findings have indicated that lncRNA-maternally expressed gene 3 (MEG3...

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Veröffentlicht in:	Oncology reports 2017-10, Vol.38 (4), p.2408-2416
Hauptverfasser:	Zhang, Ling, Liang, Xin, Li, Yuxiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Apoptosis - genetics Cancer therapies Carcinogenesis - genetics Caspase 3 - genetics Caspase 9 - genetics Cell growth Cell Proliferation - genetics Chinese medicine DNA Methylation - genetics Female Gastric cancer Gene Expression Regulation, Neoplastic Genes Glioma Glioma - genetics Glioma - pathology Humans Ki-67 Antigen - genetics Kinases Laboratories Lentivirus - genetics Male Medical prognosis Mice MicroRNAs - genetics Phosphatidylinositol 3-Kinases - genetics Proliferating Cell Nuclear Antigen - genetics Promoter Regions, Genetic Proto-Oncogene Proteins c-akt - genetics RNA, Long Noncoding - genetics Rodents Roles Signal Transduction - genetics Studies Xenograft Model Antitumor Assays
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