FGF8 promotes cell proliferation and resistance to EGFR inhibitors via upregulation of EGFR in human hepatocellular carcinoma cells

Fibroblast growth factor 8 (FGF8), a member of the fibroblast growth factor (FGF) family, is upregulated in several human cancers, including HCC (HCC). Previous studies have demonstrated that FGF8 increased cell growth and invasion of tumor cells. In the present study we investigated whether FGF8 is...

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Veröffentlicht in:	Oncology reports 2017-10, Vol.38 (4), p.2205-2210
Hauptverfasser:	Pei, Yuanmin, Sun, Xueling, Guo, Xiwei, Yin, Huashan, Wang, Le, Tian, Fugu, Jing, Hongxi, Liang, Xiaobo, Xu, Jun, Shi, Pengcheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Androgens Angiogenesis Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell growth Cell Movement - drug effects Cell Proliferation - drug effects Chemotherapy Drug resistance Drug Resistance, Neoplasm - genetics ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Fibroblast Growth Factor 8 - genetics Fibroblasts Gene expression Gene Expression Regulation, Neoplastic Growth factors Hep G2 Cells Humans Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology Phosphatase Phosphoproteins - genetics Prostate Protein Kinase Inhibitors - administration & dosage Proteins Rodents Signal Transduction - drug effects Transcription Factors Transcriptional Activation - drug effects
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