Comparison of HIF1A-AS1 and HIF1A-AS2 in regulating HIF-1α and the osteogenic differentiation of PDLCs under hypoxia

Hypoxia-inducible factor-1α (HIF-1α) is essential for regulating the osteogenic differentiation of periodontal ligament cells (PDLCs). The regulatory mechanism of HIF-1α transcription is still not clear. Recently, two long non-coding RNAs, HIF1A antisense RNA 1 (HIF1A-AS1) and HIF1A antisense RNA 2...

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Veröffentlicht in:	International journal of molecular medicine 2017-11, Vol.40 (5), p.1529-1536
Hauptverfasser:	Chen, Dongru, Wu, Liping, Liu, Lu, Gong, Qimei, Zheng, Jinxuan, Peng, Caixia, Deng, Jianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers Cell Differentiation - genetics Cell Hypoxia Cells, Cultured Computational Biology - methods Gene Expression Gene Silencing Genes Genomes Growth factors HIF1A antisense RNA 1 HIF1A antisense RNA 2 Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics hypoxia-inducible factor-1α Kinases Ligaments Oral diseases Orthodontics Osteogenesis - genetics osteogenic differentiation Periodontal Ligament - cytology periodontal ligament cells Proteins RNA Interference RNA, Antisense - genetics Skin & tissue grafts Tissue engineering Transcription factors Young Adult
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