Glutamate injury-induced epileptogenesis in hippocampal neurons : An in vitro model of stroke-induced epilepsy

Stroke is the major cause of acquired epilepsy. The mechanisms of ischemia-induced epileptogenesis are not understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis in several models. The objective of this study was to develop an in vitro model of epileptogenesis...

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Veröffentlicht in:	Stroke (1970) 2001-10, Vol.32 (10), p.2344-2350
Hauptverfasser:	SUN, David A, SOMBATI, Sompong, DELORENZO, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Anticonvulsants - pharmacology Biological and medical sciences Cell Size - drug effects Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Dose-Response Relationship, Drug Epilepsy - etiology Epilepsy - pathology Epilepsy - physiopathology Ethosuximide - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glutamic Acid - toxicity Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiopathology Medical sciences Models, Biological Nerve Net - drug effects Nerve Net - physiopathology Nervous system (semeiology, syndromes) Neurology Neurons - cytology Neurons - drug effects Neurons - physiology Patch-Clamp Techniques Phenobarbital - pharmacology Rats Rats, Sprague-Dawley Stroke - complications Vascular diseases and vascular malformations of the nervous system
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