Alfentanil-mediated analgesia during propofol injection: no evidence for a peripheral action
We have investigated if alfentanil acts via peripheral opioid receptors to relieve the pain which occurs on injection of propofol. Thirty seconds before induction of anaesthesia and immediately after a tourniquet at 50 mm Hg greater than systolic pressure was inflated on the upper arm, patients were...
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| Veröffentlicht in: | British Journal of Anaesthesia 1996-08, Vol.77 (2), p.162-164 |
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| container_title | British Journal of Anaesthesia |
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| creator | Wrench, I J Girling, K J Hobbs, G J |
| description | We have investigated if alfentanil acts via peripheral opioid receptors to relieve the pain which occurs on injection of propofol. Thirty seconds before induction of anaesthesia and immediately after a tourniquet at 50 mm Hg greater than systolic pressure was inflated on the upper arm, patients were given either placebo (n = 22), alfentanil 1 mg (n = 22) or lignocaine 40 mg (n = 22) via an i.v. cannula in the dorsum of the hand. Pain during injection of propofol was assessed using a three-point verbal rating scale, recorded at 8-s intervals. We found a significant reduction in pain after lignocaine compared with the two other groups (P < 0.001), but there was no difference between the placebo and alfentanil groups. We conclude that alfentanil does not relieve pain on injection with propofol via an action on peripheral opioid receptors when alfentanil is limited to the forearm for 30 s before induction of anaesthesia. |
| doi_str_mv | 10.1093/bja/77.2.162 |
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Thirty seconds before induction of anaesthesia and immediately after a tourniquet at 50 mm Hg greater than systolic pressure was inflated on the upper arm, patients were given either placebo (n = 22), alfentanil 1 mg (n = 22) or lignocaine 40 mg (n = 22) via an i.v. cannula in the dorsum of the hand. Pain during injection of propofol was assessed using a three-point verbal rating scale, recorded at 8-s intervals. We found a significant reduction in pain after lignocaine compared with the two other groups (P < 0.001), but there was no difference between the placebo and alfentanil groups. We conclude that alfentanil does not relieve pain on injection with propofol via an action on peripheral opioid receptors when alfentanil is limited to the forearm for 30 s before induction of anaesthesia.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/77.2.162</identifier><identifier>PMID: 8881618</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Alfentanil - pharmacology ; Alfentanil - therapeutic use ; Analgesics ; Analgesics, Opioid - pharmacology ; Analgesics, Opioid - therapeutic use ; Anesthetics, Intravenous - adverse effects ; Anesthetics, Local - therapeutic use ; Biological and medical sciences ; Double-Blind Method ; Female ; Humans ; Infusions, Intravenous ; Lidocaine - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pain - chemically induced ; Pain - prevention & control ; Pharmacology. Drug treatments ; Propofol - adverse effects ; Receptors, Opioid - drug effects ; Tourniquets</subject><ispartof>British Journal of Anaesthesia, 1996-08, Vol.77 (2), p.162-164</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright British Medical Association Aug 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-5092e7c91bedfcd63f0ea95adb14996c9d957b63dae9b1260cb0a0f593e4a7e23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3155210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8881618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wrench, I J</creatorcontrib><creatorcontrib>Girling, K J</creatorcontrib><creatorcontrib>Hobbs, G J</creatorcontrib><title>Alfentanil-mediated analgesia during propofol injection: no evidence for a peripheral action</title><title>British Journal of Anaesthesia</title><addtitle>Br J Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>We have investigated if alfentanil acts via peripheral opioid receptors to relieve the pain which occurs on injection of propofol. Thirty seconds before induction of anaesthesia and immediately after a tourniquet at 50 mm Hg greater than systolic pressure was inflated on the upper arm, patients were given either placebo (n = 22), alfentanil 1 mg (n = 22) or lignocaine 40 mg (n = 22) via an i.v. cannula in the dorsum of the hand. Pain during injection of propofol was assessed using a three-point verbal rating scale, recorded at 8-s intervals. We found a significant reduction in pain after lignocaine compared with the two other groups (P < 0.001), but there was no difference between the placebo and alfentanil groups. We conclude that alfentanil does not relieve pain on injection with propofol via an action on peripheral opioid receptors when alfentanil is limited to the forearm for 30 s before induction of anaesthesia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alfentanil - pharmacology</subject><subject>Alfentanil - therapeutic use</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Anesthetics, Intravenous - adverse effects</subject><subject>Anesthetics, Local - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Lidocaine - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pain - chemically induced</subject><subject>Pain - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Propofol - adverse effects</subject><subject>Receptors, Opioid - drug effects</subject><subject>Tourniquets</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFTEUhoMo9VrduRWCCG6c2yQzSSbuSvELCm50J4QzyUnNZZqMyUzBf2_qvXQluDqL9zlfDyEvOdtzZvqL6QAXWu_FnivxiOz4oHmntOaPyY4xpjtmuHhKntV6YIxrYeQZORvHkSs-7siPyzlgWiHFubtFH2FFTyHBfIM1AvVbiemGLiUvOeSZxnRAt8ac3tOUKd5Fj8khDblQoAuWuPzEAjOFv9Bz8iTAXPHFqZ6T7x8_fLv63F1__fTl6vK6c4M0ayeZEaid4RP64LzqA0MwEvzEB2OUM95IPaneA5qJC8XcxIAFaXocQKPoz8nr49x2568N62oPeSvtiWq50ePApOINeneEXMm1Fgx2KfEWym_Lmb0XaZtIq7UVtols-KvTzG1qYh7gk7mWvznlUB3MoUBysT5gPZdScNawt0csb8v_Fqojic3UXcRiq4v3dn0szbn1Of678Q-yuJte</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Wrench, I J</creator><creator>Girling, K J</creator><creator>Hobbs, G J</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>19960801</creationdate><title>Alfentanil-mediated analgesia during propofol injection: no evidence for a peripheral action</title><author>Wrench, I J ; Girling, K J ; Hobbs, G J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-5092e7c91bedfcd63f0ea95adb14996c9d957b63dae9b1260cb0a0f593e4a7e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alfentanil - pharmacology</topic><topic>Alfentanil - therapeutic use</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Anesthetics, Intravenous - adverse effects</topic><topic>Anesthetics, Local - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Lidocaine - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pain - chemically induced</topic><topic>Pain - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Propofol - adverse effects</topic><topic>Receptors, Opioid - drug effects</topic><topic>Tourniquets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wrench, I J</creatorcontrib><creatorcontrib>Girling, K J</creatorcontrib><creatorcontrib>Hobbs, G J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>British Journal of Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wrench, I J</au><au>Girling, K J</au><au>Hobbs, G J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alfentanil-mediated analgesia during propofol injection: no evidence for a peripheral action</atitle><jtitle>British Journal of Anaesthesia</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>77</volume><issue>2</issue><spage>162</spage><epage>164</epage><pages>162-164</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have investigated if alfentanil acts via peripheral opioid receptors to relieve the pain which occurs on injection of propofol. Thirty seconds before induction of anaesthesia and immediately after a tourniquet at 50 mm Hg greater than systolic pressure was inflated on the upper arm, patients were given either placebo (n = 22), alfentanil 1 mg (n = 22) or lignocaine 40 mg (n = 22) via an i.v. cannula in the dorsum of the hand. Pain during injection of propofol was assessed using a three-point verbal rating scale, recorded at 8-s intervals. We found a significant reduction in pain after lignocaine compared with the two other groups (P < 0.001), but there was no difference between the placebo and alfentanil groups. We conclude that alfentanil does not relieve pain on injection with propofol via an action on peripheral opioid receptors when alfentanil is limited to the forearm for 30 s before induction of anaesthesia.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8881618</pmid><doi>10.1093/bja/77.2.162</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Alfentanil - pharmacology Alfentanil - therapeutic use Analgesics Analgesics, Opioid - pharmacology Analgesics, Opioid - therapeutic use Anesthetics, Intravenous - adverse effects Anesthetics, Local - therapeutic use Biological and medical sciences Double-Blind Method Female Humans Infusions, Intravenous Lidocaine - therapeutic use Male Medical sciences Middle Aged Neuropharmacology Pain - chemically induced Pain - prevention & control Pharmacology. Drug treatments Propofol - adverse effects Receptors, Opioid - drug effects Tourniquets |
| title | Alfentanil-mediated analgesia during propofol injection: no evidence for a peripheral action |
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