Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty
Optimal pain treatment with minimal side-effects is essential for early mobility and recovery in patients undergoing total hip arthroplasty. We investigated the analgesic effect of pregabalin and dexamethasone in this surgical procedure. One hundred and twenty patients were randomly allocated to eit...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2008-10, Vol.101 (4), p.535-541 |
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| creator | Mathiesen, O. Jacobsen, L.S. Holm, H.E. Randall, S. Adamiec-Malmstroem, L. Graungaard, B.K. Holst, P.E. Hilsted, K.L. Dahl, J.B. |
| description | Optimal pain treatment with minimal side-effects is essential for early mobility and recovery in patients undergoing total hip arthroplasty. We investigated the analgesic effect of pregabalin and dexamethasone in this surgical procedure.
One hundred and twenty patients were randomly allocated to either Group A (placebo), Group B (pregabalin 300 mg), or Group C (pregabalin 300 mg+dexamethasone 8 mg). The medication and acetaminophen 1 g were given before operation. Spinal anaesthesia was performed. Postoperative pain treatment was with acetaminophen 1 g three times daily and patient-controlled i.v morphine, 2.5 mg bolus. Nausea was treated with ondansetron. Morphine consumption, pain intensity at rest and during mobilization, nausea and vomiting, sedation, dizziness, and consumption of ondansetron were recorded 2, 4, and 24 h after operation. P |
| doi_str_mv | 10.1093/bja/aen215 |
| format | Article |
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One hundred and twenty patients were randomly allocated to either Group A (placebo), Group B (pregabalin 300 mg), or Group C (pregabalin 300 mg+dexamethasone 8 mg). The medication and acetaminophen 1 g were given before operation. Spinal anaesthesia was performed. Postoperative pain treatment was with acetaminophen 1 g three times daily and patient-controlled i.v morphine, 2.5 mg bolus. Nausea was treated with ondansetron. Morphine consumption, pain intensity at rest and during mobilization, nausea and vomiting, sedation, dizziness, and consumption of ondansetron were recorded 2, 4, and 24 h after operation. P<0.05 was considered statistically significant.
Twenty-four hour morphine consumption was significantly reduced in Groups B [mean (sd) 24 (14) mg] and C [25 (19) mg] compared with Group A [47 (28) mg]. Vomiting was reduced in Group C compared with Group B (P=0.03). Sedation was significantly increased in Group B compared with the other groups.
Pregabalin resulted in a 50% reduction in 24 h postoperative morphine requirements. This was not associated with a reduced incidence of nausea or vomiting. Pregabalin resulted in increased levels of sedation. Combining pregabalin and dexamethasone provided no additional effects on pain or opioid requirements.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aen215</identifier><identifier>PMID: 18653493</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aged ; analgesia ; analgesia, postoperative ; Analgesics, Non-Narcotic - therapeutic use ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - adverse effects ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Arthroplasty, Replacement, Hip ; Biological and medical sciences ; Consciousness - drug effects ; Dexamethasone - therapeutic use ; Double-Blind Method ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; gamma-Aminobutyric Acid - analogs & derivatives ; gamma-Aminobutyric Acid - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Morphine - administration & dosage ; Morphine - adverse effects ; pain ; Pain Measurement - methods ; pain, postoperative ; Pain, Postoperative - prevention & control ; postoperative ; Postoperative Nausea and Vomiting - chemically induced ; Postoperative Nausea and Vomiting - prevention & control ; Pregabalin ; Prospective Studies</subject><ispartof>British journal of anaesthesia : BJA, 2008-10, Vol.101 (4), p.535-541</ispartof><rights>2008 British Journal of Anaesthesia</rights><rights>The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Oct 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-364614578ea1d9ecfb26abd7f7c8692092e7750e14af93b87e16370688f105c23</citedby><cites>FETCH-LOGICAL-c516t-364614578ea1d9ecfb26abd7f7c8692092e7750e14af93b87e16370688f105c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20702354$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18653493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mathiesen, O.</creatorcontrib><creatorcontrib>Jacobsen, L.S.</creatorcontrib><creatorcontrib>Holm, H.E.</creatorcontrib><creatorcontrib>Randall, S.</creatorcontrib><creatorcontrib>Adamiec-Malmstroem, L.</creatorcontrib><creatorcontrib>Graungaard, B.K.</creatorcontrib><creatorcontrib>Holst, P.E.</creatorcontrib><creatorcontrib>Hilsted, K.L.</creatorcontrib><creatorcontrib>Dahl, J.B.</creatorcontrib><title>Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>Optimal pain treatment with minimal side-effects is essential for early mobility and recovery in patients undergoing total hip arthroplasty. We investigated the analgesic effect of pregabalin and dexamethasone in this surgical procedure.
One hundred and twenty patients were randomly allocated to either Group A (placebo), Group B (pregabalin 300 mg), or Group C (pregabalin 300 mg+dexamethasone 8 mg). The medication and acetaminophen 1 g were given before operation. Spinal anaesthesia was performed. Postoperative pain treatment was with acetaminophen 1 g three times daily and patient-controlled i.v morphine, 2.5 mg bolus. Nausea was treated with ondansetron. Morphine consumption, pain intensity at rest and during mobilization, nausea and vomiting, sedation, dizziness, and consumption of ondansetron were recorded 2, 4, and 24 h after operation. P<0.05 was considered statistically significant.
Twenty-four hour morphine consumption was significantly reduced in Groups B [mean (sd) 24 (14) mg] and C [25 (19) mg] compared with Group A [47 (28) mg]. Vomiting was reduced in Group C compared with Group B (P=0.03). Sedation was significantly increased in Group B compared with the other groups.
Pregabalin resulted in a 50% reduction in 24 h postoperative morphine requirements. This was not associated with a reduced incidence of nausea or vomiting. Pregabalin resulted in increased levels of sedation. Combining pregabalin and dexamethasone provided no additional effects on pain or opioid requirements.</description><subject>Aged</subject><subject>analgesia</subject><subject>analgesia, postoperative</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Arthroplasty, Replacement, Hip</subject><subject>Biological and medical sciences</subject><subject>Consciousness - drug effects</subject><subject>Dexamethasone - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>gamma-Aminobutyric Acid - analogs & derivatives</subject><subject>gamma-Aminobutyric Acid - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - adverse effects</subject><subject>pain</subject><subject>Pain Measurement - methods</subject><subject>pain, postoperative</subject><subject>Pain, Postoperative - prevention & control</subject><subject>postoperative</subject><subject>Postoperative Nausea and Vomiting - chemically induced</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Pregabalin</subject><subject>Prospective Studies</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M-L1DAUwPEgijuuXvwDpAhehLpJmh-NN1nUFRZcUEG8hNf01cnYaWqSLjv-9UY67l7EU0L45D34EvKU0VeMmuas28EZ4MSZvEc2TGhWK63ZfbKhlOqaGsZPyKOUdpQyzY18SE5Yq2QjTLMh01XE79DB6KcKpr7q8Qb2mLeQwoTVEGI1h5TDjBGyv8ZqhgJdmHIM4-sKqlg-hb3_hf3f17FcU176Q1Xk1s8VxLyNYR4h5cNj8mCAMeGT43lKvrx7-_n8or78-P7D-ZvL2kmmct0ooZiQukVgvUE3dFxB1-tBu1YZTg1HrSVFJmAwTddqZKrRVLXtwKh0vDklz9e5cww_F0zZ7sISp7LSMqO1Ni0zBb1ckYshpYiDnaPfQzxYRu2fsraUtWvZgp8dJy7dHvs7ekxZwIsjgORgHEoZ59Ot41RT3khx58Iy_39hvTqfMt7cSog_rNKNlvbi6zcrWsHEpytudfFi9Vi6XnuMNjmPk8PeR3TZ9sH_a81vd0qwjQ</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Mathiesen, O.</creator><creator>Jacobsen, L.S.</creator><creator>Holm, H.E.</creator><creator>Randall, S.</creator><creator>Adamiec-Malmstroem, L.</creator><creator>Graungaard, B.K.</creator><creator>Holst, P.E.</creator><creator>Hilsted, K.L.</creator><creator>Dahl, J.B.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20081001</creationdate><title>Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty</title><author>Mathiesen, O. ; Jacobsen, L.S. ; Holm, H.E. ; Randall, S. ; Adamiec-Malmstroem, L. ; Graungaard, B.K. ; Holst, P.E. ; Hilsted, K.L. ; Dahl, J.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-364614578ea1d9ecfb26abd7f7c8692092e7750e14af93b87e16370688f105c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>analgesia</topic><topic>analgesia, postoperative</topic><topic>Analgesics, Non-Narcotic - therapeutic use</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Arthroplasty, Replacement, Hip</topic><topic>Biological and medical sciences</topic><topic>Consciousness - drug effects</topic><topic>Dexamethasone - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>gamma-Aminobutyric Acid - analogs & derivatives</topic><topic>gamma-Aminobutyric Acid - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - adverse effects</topic><topic>pain</topic><topic>Pain Measurement - methods</topic><topic>pain, postoperative</topic><topic>Pain, Postoperative - prevention & control</topic><topic>postoperative</topic><topic>Postoperative Nausea and Vomiting - chemically induced</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Pregabalin</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mathiesen, O.</creatorcontrib><creatorcontrib>Jacobsen, L.S.</creatorcontrib><creatorcontrib>Holm, H.E.</creatorcontrib><creatorcontrib>Randall, S.</creatorcontrib><creatorcontrib>Adamiec-Malmstroem, L.</creatorcontrib><creatorcontrib>Graungaard, B.K.</creatorcontrib><creatorcontrib>Holst, P.E.</creatorcontrib><creatorcontrib>Hilsted, K.L.</creatorcontrib><creatorcontrib>Dahl, J.B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mathiesen, O.</au><au>Jacobsen, L.S.</au><au>Holm, H.E.</au><au>Randall, S.</au><au>Adamiec-Malmstroem, L.</au><au>Graungaard, B.K.</au><au>Holst, P.E.</au><au>Hilsted, K.L.</au><au>Dahl, J.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>101</volume><issue>4</issue><spage>535</spage><epage>541</epage><pages>535-541</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Optimal pain treatment with minimal side-effects is essential for early mobility and recovery in patients undergoing total hip arthroplasty. We investigated the analgesic effect of pregabalin and dexamethasone in this surgical procedure.
One hundred and twenty patients were randomly allocated to either Group A (placebo), Group B (pregabalin 300 mg), or Group C (pregabalin 300 mg+dexamethasone 8 mg). The medication and acetaminophen 1 g were given before operation. Spinal anaesthesia was performed. Postoperative pain treatment was with acetaminophen 1 g three times daily and patient-controlled i.v morphine, 2.5 mg bolus. Nausea was treated with ondansetron. Morphine consumption, pain intensity at rest and during mobilization, nausea and vomiting, sedation, dizziness, and consumption of ondansetron were recorded 2, 4, and 24 h after operation. P<0.05 was considered statistically significant.
Twenty-four hour morphine consumption was significantly reduced in Groups B [mean (sd) 24 (14) mg] and C [25 (19) mg] compared with Group A [47 (28) mg]. Vomiting was reduced in Group C compared with Group B (P=0.03). Sedation was significantly increased in Group B compared with the other groups.
Pregabalin resulted in a 50% reduction in 24 h postoperative morphine requirements. This was not associated with a reduced incidence of nausea or vomiting. Pregabalin resulted in increased levels of sedation. Combining pregabalin and dexamethasone provided no additional effects on pain or opioid requirements.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18653493</pmid><doi>10.1093/bja/aen215</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of anaesthesia : BJA, 2008-10, Vol.101 (4), p.535-541 |
| issn | 0007-0912 1471-6771 |
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| subjects | Aged analgesia analgesia, postoperative Analgesics, Non-Narcotic - therapeutic use Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arthroplasty, Replacement, Hip Biological and medical sciences Consciousness - drug effects Dexamethasone - therapeutic use Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Female gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - therapeutic use Humans Male Medical sciences Middle Aged Morphine - administration & dosage Morphine - adverse effects pain Pain Measurement - methods pain, postoperative Pain, Postoperative - prevention & control postoperative Postoperative Nausea and Vomiting - chemically induced Postoperative Nausea and Vomiting - prevention & control Pregabalin Prospective Studies |
| title | Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty |
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