Effect of tramadol on depth of anaesthesia
We have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. A two-channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1996-03, Vol.76 (3), p.415-418 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | Coetzee, J F Maritz, J S du Toit, J C |
| description | We have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. A two-channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and 100 mg i.v. and the third group received saline. Tramadol caused significant, dose-dependent activation of the EEG, evidenced by increased frequencies and decreased amplitudes, but these changes were small and probably unimportant. Derived EEG variables did not approach values known to be associated with near-awakening during isoflurane anaesthesia. No patient moved on skin incision and there were no incidences of free recall. |
| doi_str_mv | 10.1093/bja/76.3.415 |
| format | Article |
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A two-channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and 100 mg i.v. and the third group received saline. Tramadol caused significant, dose-dependent activation of the EEG, evidenced by increased frequencies and decreased amplitudes, but these changes were small and probably unimportant. Derived EEG variables did not approach values known to be associated with near-awakening during isoflurane anaesthesia. 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A two-channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and 100 mg i.v. and the third group received saline. Tramadol caused significant, dose-dependent activation of the EEG, evidenced by increased frequencies and decreased amplitudes, but these changes were small and probably unimportant. Derived EEG variables did not approach values known to be associated with near-awakening during isoflurane anaesthesia. No patient moved on skin incision and there were no incidences of free recall.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Anesthesia, Inhalation</subject><subject>Anesthetics, Inhalation</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Electroencephalography - drug effects</subject><subject>Humans</subject><subject>Isoflurane</subject><subject>Medical sciences</subject><subject>Mental Recall - drug effects</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Nitrous Oxide</subject><subject>Pharmacology. Drug treatments</subject><subject>Propofol</subject><subject>Succinylcholine</subject><subject>Tramadol - pharmacology</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVZvXoUigiBum9nMJs1RSv2Aghc9hzSZpVva3ZrsCv57U1p6EjwNzDzzvvAwdg18BFyL8WJlx0qOxAihOGF9QAWZVApOWZ9zrjKuIT9nFzGuOAeV66LHehM1KQCxzx5mZUmuHTblsA12Y32zHjb10NO2Xe6WtrYU2yXFyl6ys9KuI10d5oB9Ps8-pq_Z_P3lbfo0zxxORJvlXnpLHAmERPSEtkDl9YQIkaPSoArnnS6LAiRHAZLKXIscrFOea4ViwG73udvQfHWp3ayaLtSp0oBWSknUeYIe95ALTYyBSrMN1caGHwPc7LSYpMUoaYRJWhJ-c8jsFhvyR_jgId3vDncbnV2XwdauikdMJJEIPGH3e6zptv8Vyj1JydR3RcFEV1HtyFch-Ta-qf5-_AVN1YZ5</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Coetzee, J F</creator><creator>Maritz, J S</creator><creator>du Toit, J C</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>19960301</creationdate><title>Effect of tramadol on depth of anaesthesia</title><author>Coetzee, J F ; Maritz, J S ; du Toit, J C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-2d6dae04e13644de4a547d98ee440479175cdc9f551604316ef29321ac7d09743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Anesthesia, Inhalation</topic><topic>Anesthetics, Inhalation</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Electroencephalography - drug effects</topic><topic>Humans</topic><topic>Isoflurane</topic><topic>Medical sciences</topic><topic>Mental Recall - drug effects</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Nitrous Oxide</topic><topic>Pharmacology. Drug treatments</topic><topic>Propofol</topic><topic>Succinylcholine</topic><topic>Tramadol - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coetzee, J F</creatorcontrib><creatorcontrib>Maritz, J S</creatorcontrib><creatorcontrib>du Toit, J C</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coetzee, J F</au><au>Maritz, J S</au><au>du Toit, J C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of tramadol on depth of anaesthesia</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>76</volume><issue>3</issue><spage>415</spage><epage>418</epage><pages>415-418</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. 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| ispartof | British journal of anaesthesia : BJA, 1996-03, Vol.76 (3), p.415-418 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Analgesics Analgesics, Opioid - pharmacology Anesthesia, Inhalation Anesthetics, Inhalation Biological and medical sciences Dose-Response Relationship, Drug Drug Interactions Electroencephalography - drug effects Humans Isoflurane Medical sciences Mental Recall - drug effects Middle Aged Neuropharmacology Nitrous Oxide Pharmacology. Drug treatments Propofol Succinylcholine Tramadol - pharmacology |
| title | Effect of tramadol on depth of anaesthesia |
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