Cisplatin‐conjugated gold nanoparticles as a theranostic agent for head and neck cancer

Background The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. Methods We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG‐GNPs). Their penetration into tumor...

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Veröffentlicht in:	Head & neck 2018-01, Vol.40 (1), p.70-78
Hauptverfasser:	Davidi, Erez Shmuel, Dreifuss, Tamar, Motiei, Menachem, Shai, Eliezer, Bragilovski, Dimitri, Lubimov, Leon, Kindler, Marc Jose Jonathan, Popovtzer, Aron, Don, Jeremy, Popovtzer, Rachela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor activity Cancer Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cell Survival Chemotherapy Cisplatin Cisplatin - administration & dosage Combined Modality Therapy Disease Models, Animal Drug Carriers - radiation effects Gold gold nanoparticles Head & neck cancer Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans In Vitro Techniques Metal Nanoparticles - administration & dosage Mice Nanoparticles Radiation-Sensitizing Agents - administration & dosage radiotherapy Random Allocation Sensitivity and Specificity Squamous Cell Carcinoma of Head and Neck Theranostic Nanomedicine - methods Toxicity Tumor cells Tumor Cells, Cultured
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