Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine
"Crack" cocaine (alkaloidal cocaine) induces ischemic stroke. However, the mechanisms by which this occurs are not well documented in humans. We present pertinent information on three patients whose ischemic strokes involved the territory of the internal carotid artery and were associated...
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| Veröffentlicht in: | Stroke (1970) 1995-06, Vol.26 (6), p.1114-1118 |
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| container_title | Stroke (1970) |
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| creator | KONZEN, J. P LEVINE, S. R GARCIA, J. H |
| description | "Crack" cocaine (alkaloidal cocaine) induces ischemic stroke. However, the mechanisms by which this occurs are not well documented in humans. We present pertinent information on three patients whose ischemic strokes involved the territory of the internal carotid artery and were associated with crack use.
These patients were investigated clinically, radiologically, intraoperatively, and/or histopathologically at the same institution, and the diagnostic evaluations did not reveal a definite cardiac or hematologic cause of stroke. Large filling defects were noted on conventional carotid angiography in two of these patients; in the third patient, the histopathological changes were compatible with vasospasm. To our knowledge, these changes have not been previously documented in human arteries.
We suggest that some brain infarcts among crack cocaine users may result from vasospasm of large arteries and secondary intravascular thrombosis. |
| doi_str_mv | 10.1161/01.str.26.6.1114 |
| format | Article |
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These patients were investigated clinically, radiologically, intraoperatively, and/or histopathologically at the same institution, and the diagnostic evaluations did not reveal a definite cardiac or hematologic cause of stroke. Large filling defects were noted on conventional carotid angiography in two of these patients; in the third patient, the histopathological changes were compatible with vasospasm. To our knowledge, these changes have not been previously documented in human arteries.
We suggest that some brain infarcts among crack cocaine users may result from vasospasm of large arteries and secondary intravascular thrombosis.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.str.26.6.1114</identifier><identifier>PMID: 7762031</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Carotid Artery, Internal - diagnostic imaging ; Cerebral Angiography ; Cerebral Infarction - diagnostic imaging ; Cerebral Infarction - etiology ; Cerebrovascular Disorders - chemically induced ; Cerebrovascular Disorders - diagnostic imaging ; Cerebrovascular Disorders - physiopathology ; Crack Cocaine - adverse effects ; Drug addictions ; Female ; Humans ; Intracranial Embolism and Thrombosis - chemically induced ; Intracranial Embolism and Thrombosis - physiopathology ; Intracranial Embolism and Thrombosis - surgery ; Ischemic Attack, Transient - chemically induced ; Ischemic Attack, Transient - physiopathology ; Male ; Medical sciences ; Middle Aged ; Tomography, X-Ray Computed ; Toxicology</subject><ispartof>Stroke (1970), 1995-06, Vol.26 (6), p.1114-1118</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jun 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-77383a980b51e5762f6898a6d81de9afaf5d9cea9bd753dacf3b1d33be4a73e93</citedby><cites>FETCH-LOGICAL-c499t-77383a980b51e5762f6898a6d81de9afaf5d9cea9bd753dacf3b1d33be4a73e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3686,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3542829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7762031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KONZEN, J. P</creatorcontrib><creatorcontrib>LEVINE, S. R</creatorcontrib><creatorcontrib>GARCIA, J. H</creatorcontrib><title>Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>"Crack" cocaine (alkaloidal cocaine) induces ischemic stroke. However, the mechanisms by which this occurs are not well documented in humans. We present pertinent information on three patients whose ischemic strokes involved the territory of the internal carotid artery and were associated with crack use.
These patients were investigated clinically, radiologically, intraoperatively, and/or histopathologically at the same institution, and the diagnostic evaluations did not reveal a definite cardiac or hematologic cause of stroke. Large filling defects were noted on conventional carotid angiography in two of these patients; in the third patient, the histopathological changes were compatible with vasospasm. To our knowledge, these changes have not been previously documented in human arteries.
We suggest that some brain infarcts among crack cocaine users may result from vasospasm of large arteries and secondary intravascular thrombosis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carotid Artery, Internal - diagnostic imaging</subject><subject>Cerebral Angiography</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Cerebral Infarction - etiology</subject><subject>Cerebrovascular Disorders - chemically induced</subject><subject>Cerebrovascular Disorders - diagnostic imaging</subject><subject>Cerebrovascular Disorders - physiopathology</subject><subject>Crack Cocaine - adverse effects</subject><subject>Drug addictions</subject><subject>Female</subject><subject>Humans</subject><subject>Intracranial Embolism and Thrombosis - chemically induced</subject><subject>Intracranial Embolism and Thrombosis - physiopathology</subject><subject>Intracranial Embolism and Thrombosis - surgery</subject><subject>Ischemic Attack, Transient - chemically induced</subject><subject>Ischemic Attack, Transient - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Tomography, X-Ray Computed</subject><subject>Toxicology</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UEtLw0AQXkSptXr3IiziNXUfySZ7FPEFBUGr12WyD5o2ydbd5OC_d2tLTwMz32s-hK4pmVMq6D2h8ziEORNzkRY0P0FTWrA8ywWrTtGUEC4zlkt5ji5iXBNCGK-KCZqUpWCE0ylS3xB93ELsMPQGD6vgu3qM2PnQwdD4HkPEWx9jU7cWd1avoG9iF7F3ODn7jcXBtjDYxPUY2g20vjHQYu01NL29RGcO2mivDnOGvp6flo-v2eL95e3xYZHplG7IypJXHGRF6oLaIoVzopIVCFNRYyU4cIWR2oKsTVlwA9rxmhrOa5tDya3kM3S7190G_zPaOKi1H0OfLBWV_-oyTyCyB-mQPgrWqW1oOgi_ihK161MRqj6XH4oJJdSuz0S5OeiOdWfNkXAoMN3vDneIGloXoNdNPMJ4kbOKSf4H_FJ_hQ</recordid><startdate>19950601</startdate><enddate>19950601</enddate><creator>KONZEN, J. P</creator><creator>LEVINE, S. R</creator><creator>GARCIA, J. H</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>19950601</creationdate><title>Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine</title><author>KONZEN, J. P ; LEVINE, S. R ; GARCIA, J. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-77383a980b51e5762f6898a6d81de9afaf5d9cea9bd753dacf3b1d33be4a73e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carotid Artery, Internal - diagnostic imaging</topic><topic>Cerebral Angiography</topic><topic>Cerebral Infarction - diagnostic imaging</topic><topic>Cerebral Infarction - etiology</topic><topic>Cerebrovascular Disorders - chemically induced</topic><topic>Cerebrovascular Disorders - diagnostic imaging</topic><topic>Cerebrovascular Disorders - physiopathology</topic><topic>Crack Cocaine - adverse effects</topic><topic>Drug addictions</topic><topic>Female</topic><topic>Humans</topic><topic>Intracranial Embolism and Thrombosis - chemically induced</topic><topic>Intracranial Embolism and Thrombosis - physiopathology</topic><topic>Intracranial Embolism and Thrombosis - surgery</topic><topic>Ischemic Attack, Transient - chemically induced</topic><topic>Ischemic Attack, Transient - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Tomography, X-Ray Computed</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KONZEN, J. P</creatorcontrib><creatorcontrib>LEVINE, S. R</creatorcontrib><creatorcontrib>GARCIA, J. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KONZEN, J. P</au><au>LEVINE, S. R</au><au>GARCIA, J. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>1995-06-01</date><risdate>1995</risdate><volume>26</volume><issue>6</issue><spage>1114</spage><epage>1118</epage><pages>1114-1118</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>"Crack" cocaine (alkaloidal cocaine) induces ischemic stroke. However, the mechanisms by which this occurs are not well documented in humans. We present pertinent information on three patients whose ischemic strokes involved the territory of the internal carotid artery and were associated with crack use.
These patients were investigated clinically, radiologically, intraoperatively, and/or histopathologically at the same institution, and the diagnostic evaluations did not reveal a definite cardiac or hematologic cause of stroke. Large filling defects were noted on conventional carotid angiography in two of these patients; in the third patient, the histopathological changes were compatible with vasospasm. To our knowledge, these changes have not been previously documented in human arteries.
We suggest that some brain infarcts among crack cocaine users may result from vasospasm of large arteries and secondary intravascular thrombosis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>7762031</pmid><doi>10.1161/01.str.26.6.1114</doi><tpages>5</tpages></addata></record> |
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| ispartof | Stroke (1970), 1995-06, Vol.26 (6), p.1114-1118 |
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| language | eng |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Carotid Artery, Internal - diagnostic imaging Cerebral Angiography Cerebral Infarction - diagnostic imaging Cerebral Infarction - etiology Cerebrovascular Disorders - chemically induced Cerebrovascular Disorders - diagnostic imaging Cerebrovascular Disorders - physiopathology Crack Cocaine - adverse effects Drug addictions Female Humans Intracranial Embolism and Thrombosis - chemically induced Intracranial Embolism and Thrombosis - physiopathology Intracranial Embolism and Thrombosis - surgery Ischemic Attack, Transient - chemically induced Ischemic Attack, Transient - physiopathology Male Medical sciences Middle Aged Tomography, X-Ray Computed Toxicology |
| title | Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine |
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