Identification, chemical synthesis and heterologous expression of an antinociceptive peptide from the veined tree frog Trachycephalus typhonius

A proteinic fraction from the skin secretion of Trachycephalus typhonius showed antinociceptive activity in mice when tested by the Hot Plate method. This fraction was purified, and a peptide named Tt7 with a molecular mass of 6,509.7 Da was identified. The primary structure of Tt7 was elucidated. C...

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