Development of an alternative zebrafish model for drug‐induced intestinal toxicity

An evaluation of intestinal toxicity is important because the mucosal lining of the gastrointestinal tract is the first barrier for oral xenobiotics. Until now, a rat model has been recommended as the standard intestinal toxicity model and the Caco‐2 cell line, originated from a human colon adenocar...

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Veröffentlicht in:	Journal of applied toxicology 2018-02, Vol.38 (2), p.259-273
Hauptverfasser:	Ryu, Bokyeong, Kim, C‐Yoon, Oh, Hanseul, Kim, Ukjin, Kim, Jin, Jung, Cho‐Rok, Lee, Byoung‐Hee, Lee, Seungki, Chang, Seo‐Na, Lee, Ji Min, Chung, Hyung‐Min, Park, Jae‐Hak
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma alternative Animal models Animal Testing Alternatives Animals Apoptosis B-cell lymphoma Caco-2 Cells Caco‐2 cell Caspase Caspase-9 Cell culture Colon Cytochrome Cytochrome P450 Danio rerio Diclofenac Diclofenac - toxicity Drug-Related Side Effects and Adverse Reactions - etiology Evaluation Gastrointestinal tract Gene expression Genes Glutathione Glutathione peroxidase Heme Humans Immune system indomethacin Indomethacin - toxicity Interleukin 1 Intestinal Mucosa - drug effects intestinal toxicity Intestine Lethal Dose 50 Lymphocytes B Lymphoma Metabolism Methotrexate Methotrexate - toxicity Mimicry Mucosa Nitric oxide Nonsteroidal anti-inflammatory drugs Oxidative stress Peroxidase Polymerase chain reaction Proteins rat Rats Rats, Sprague-Dawley Rodents Superoxide dismutase Toll-like receptors Toxicants Toxicity Toxicity Tests - methods Xenobiotics Zebrafish
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