Zinc Transporter Proteins
Zinc, which is involved in the structure of all enzyme classes, is a micro nutrient element and necessary for growth and development. The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping z...
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| Veröffentlicht in: | Neurochemical research 2018-03, Vol.43 (3), p.517-530 |
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| creator | Baltaci, Abdulkerim Kasim Yuce, Kemal |
| description | Zinc, which is involved in the structure of all enzyme classes, is a micro nutrient element and necessary for growth and development. The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping zinc at certain concentrations. Based on their predicted membrane topology, Zn transporters are divided into two major families, SLC39s/ZIPs and SLC30s/ZnTs, which transport Zn in opposite directions through cellular and intracellular membranes. ZIPs increases the zinc concentration in the cytosol. For this, the ZIPs carries the zinc from extracellular and intracellular compartments to the cytosol. ZnTs, reduces the concentration of zinc in the cytosol. For this, ZnTs carries the zinc from the cytosol to extracellular and intracellular compartments. After being transported to the cell, 50% of the zinc is found in the cytoplasm, 30–40% in the nucleus, and 10% in the plasma and organelle membranes. The expression of many zinc transporter proteins in the cell is depending on the concentration of zinc and the physiological problems. The aim of this study is to give information about association of zinc transporter proteins with physiological events and health problems. |
| doi_str_mv | 10.1007/s11064-017-2454-y |
| format | Article |
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The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping zinc at certain concentrations. Based on their predicted membrane topology, Zn transporters are divided into two major families, SLC39s/ZIPs and SLC30s/ZnTs, which transport Zn in opposite directions through cellular and intracellular membranes. ZIPs increases the zinc concentration in the cytosol. For this, the ZIPs carries the zinc from extracellular and intracellular compartments to the cytosol. ZnTs, reduces the concentration of zinc in the cytosol. For this, ZnTs carries the zinc from the cytosol to extracellular and intracellular compartments. After being transported to the cell, 50% of the zinc is found in the cytoplasm, 30–40% in the nucleus, and 10% in the plasma and organelle membranes. The expression of many zinc transporter proteins in the cell is depending on the concentration of zinc and the physiological problems. The aim of this study is to give information about association of zinc transporter proteins with physiological events and health problems.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-017-2454-y</identifier><identifier>PMID: 29243032</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biochemistry ; Biological Transport - physiology ; Biomedical and Life Sciences ; Biomedicine ; Carrier Proteins - metabolism ; Cation Transport Proteins - metabolism ; Cell Biology ; Compartments ; Cytoplasm ; Cytoplasm - metabolism ; Cytosol ; Health problems ; Homeostasis ; Homeostasis - physiology ; Humans ; Intracellular ; Membranes ; Neurochemistry ; Neurology ; Neurosciences ; Nuclei ; Physiology ; Proteins ; Review Paper ; Topology ; Toxicity ; Zinc ; Zinc - metabolism ; Zinc transporter</subject><ispartof>Neurochemical research, 2018-03, Vol.43 (3), p.517-530</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2017</rights><rights>Neurochemical Research is a copyright of Springer, (2017). 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The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping zinc at certain concentrations. Based on their predicted membrane topology, Zn transporters are divided into two major families, SLC39s/ZIPs and SLC30s/ZnTs, which transport Zn in opposite directions through cellular and intracellular membranes. ZIPs increases the zinc concentration in the cytosol. For this, the ZIPs carries the zinc from extracellular and intracellular compartments to the cytosol. ZnTs, reduces the concentration of zinc in the cytosol. For this, ZnTs carries the zinc from the cytosol to extracellular and intracellular compartments. After being transported to the cell, 50% of the zinc is found in the cytoplasm, 30–40% in the nucleus, and 10% in the plasma and organelle membranes. The expression of many zinc transporter proteins in the cell is depending on the concentration of zinc and the physiological problems. 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Yuce, Kemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8b56b24363e4deab037ff7bdb038d9577f890bc0ba0929e89c1f580b8f2d12783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological Transport - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carrier Proteins - metabolism</topic><topic>Cation Transport Proteins - metabolism</topic><topic>Cell Biology</topic><topic>Compartments</topic><topic>Cytoplasm</topic><topic>Cytoplasm - metabolism</topic><topic>Cytosol</topic><topic>Health problems</topic><topic>Homeostasis</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Intracellular</topic><topic>Membranes</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nuclei</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Review Paper</topic><topic>Topology</topic><topic>Toxicity</topic><topic>Zinc</topic><topic>Zinc - metabolism</topic><topic>Zinc transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baltaci, Abdulkerim Kasim</creatorcontrib><creatorcontrib>Yuce, Kemal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baltaci, Abdulkerim Kasim</au><au>Yuce, Kemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc Transporter Proteins</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>43</volume><issue>3</issue><spage>517</spage><epage>530</epage><pages>517-530</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Zinc, which is involved in the structure of all enzyme classes, is a micro nutrient element and necessary for growth and development. The ability of zinc to function without causing toxic effects is depends on the protection of its homeostasis. Zinc transporter proteins are responsible for keeping zinc at certain concentrations. Based on their predicted membrane topology, Zn transporters are divided into two major families, SLC39s/ZIPs and SLC30s/ZnTs, which transport Zn in opposite directions through cellular and intracellular membranes. ZIPs increases the zinc concentration in the cytosol. For this, the ZIPs carries the zinc from extracellular and intracellular compartments to the cytosol. ZnTs, reduces the concentration of zinc in the cytosol. For this, ZnTs carries the zinc from the cytosol to extracellular and intracellular compartments. After being transported to the cell, 50% of the zinc is found in the cytoplasm, 30–40% in the nucleus, and 10% in the plasma and organelle membranes. 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| subjects | Animals Biochemistry Biological Transport - physiology Biomedical and Life Sciences Biomedicine Carrier Proteins - metabolism Cation Transport Proteins - metabolism Cell Biology Compartments Cytoplasm Cytoplasm - metabolism Cytosol Health problems Homeostasis Homeostasis - physiology Humans Intracellular Membranes Neurochemistry Neurology Neurosciences Nuclei Physiology Proteins Review Paper Topology Toxicity Zinc Zinc - metabolism Zinc transporter |
| title | Zinc Transporter Proteins |
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