Anti-endotoxin mechanism of the KW4 peptide in inflammation in RAW 264.7 cells induced by LTA and drug-resistant Staphylococcus aureus 1630
Drug-resistant microorganism infections cause serious disease and can lead to mortality and morbidity. In particular, Staphylococcus aureus induces pyrogenic and toxigenic infections, and drug-resistance occurs rapidly. Multidrug-resistant S. aureus , such as methicillin-resistant S. aureus and meth...
Gespeichert in:
| Veröffentlicht in: | Amino acids 2018-04, Vol.50 (3-4), p.363-372 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 372 |
|---|---|
| container_issue | 3-4 |
| container_start_page | 363 |
| container_title | Amino acids |
| container_volume | 50 |
| creator | Lee, Jong-kook Park, Yoonkyung |
| description | Drug-resistant microorganism infections cause serious disease and can lead to mortality and morbidity. In particular,
Staphylococcus aureus
induces pyrogenic and toxigenic infections, and drug-resistance occurs rapidly. Multidrug-resistant
S. aureus
, such as methicillin-resistant
S. aureus
and methicillin-sensitive
S. aureus
, can also cause immunodeficiency and immune deficiency syndrome from lipoteichoic acid. However, antimicrobial peptides, such as KW4, have strong antimicrobial activity, low cytotoxicity, and high neutralization activity against endotoxin substances from Gram-negative bacteria. The objective of this study was to use a synthetic KW4 antimicrobial peptide to evaluate the inhibition of drug-resistance development, antimicrobial activity, and neutralizing activity in
S. aureus
Gram-positive bacteria. The KW4 peptide showed strong antimicrobial activity against drug-resistant
S. aureus
strains and significantly increased the anti-neutralizing activity of lipoteichoic acid in
S. aureus
1630 drug-resistant bacteria. In addition,
S. aureus
ATCC 29213 did not develop resistance to KW4 as with other antibiotic drugs. These results suggest that the KW4 peptide is an effective antibiotic and anti-neutralizing agent against multidrug-resistant
S. aureus
strains. |
| doi_str_mv | 10.1007/s00726-017-2518-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1976300328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1976300328</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-136c764f3fbe69cff94242a39e122f0e68b8e5c7aa49bfd42eed82f2a9109143</originalsourceid><addsrcrecordid>eNp1kM9q3DAQxkVpaLZJH6CXIuhZqSRrZeu4hP6jC4VkIUchS6Osgy25kgz1M_Slq2XT0ksvM8zMN98MP4TeMnrDKG0_5Bq4JJS1hG9ZR9YXaMNE0xHOlHqJNlQ1igixZZfodc5PlDLeMfkKXXLFm67byg36tQtlIBBcLPHnEPAE9mjCkCccPS5HwN8eBJ5hLoMDXOdD8KOZJlOGeCrw3e4BcyluWmxhHHNtucWCw_2K94cdNsFhl5ZHkiAPuZhQ8H0x83Edo43WLhmbJUFNTDb0Gl14M2Z485yv0OHTx8PtF7L__vnr7W5PbNPyQlgjbSuFb3wPUlnvleCCm0YB49xTkF3fwda2xgjVeyc4gOu450YxqiqeK_T-bDun-GOBXPRTXFKoFzVTbf2DNryrKnZW2RRzTuD1nIbJpFUzqk_09Zm-rvT1ib5e6867Z-eln8D93fiDuwr4WZDrKDxC-uf0f11_A0_pj-Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1976300328</pqid></control><display><type>article</type><title>Anti-endotoxin mechanism of the KW4 peptide in inflammation in RAW 264.7 cells induced by LTA and drug-resistant Staphylococcus aureus 1630</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Lee, Jong-kook ; Park, Yoonkyung</creator><creatorcontrib>Lee, Jong-kook ; Park, Yoonkyung</creatorcontrib><description>Drug-resistant microorganism infections cause serious disease and can lead to mortality and morbidity. In particular,
Staphylococcus aureus
induces pyrogenic and toxigenic infections, and drug-resistance occurs rapidly. Multidrug-resistant
S. aureus
, such as methicillin-resistant
S. aureus
and methicillin-sensitive
S. aureus
, can also cause immunodeficiency and immune deficiency syndrome from lipoteichoic acid. However, antimicrobial peptides, such as KW4, have strong antimicrobial activity, low cytotoxicity, and high neutralization activity against endotoxin substances from Gram-negative bacteria. The objective of this study was to use a synthetic KW4 antimicrobial peptide to evaluate the inhibition of drug-resistance development, antimicrobial activity, and neutralizing activity in
S. aureus
Gram-positive bacteria. The KW4 peptide showed strong antimicrobial activity against drug-resistant
S. aureus
strains and significantly increased the anti-neutralizing activity of lipoteichoic acid in
S. aureus
1630 drug-resistant bacteria. In addition,
S. aureus
ATCC 29213 did not develop resistance to KW4 as with other antibiotic drugs. These results suggest that the KW4 peptide is an effective antibiotic and anti-neutralizing agent against multidrug-resistant
S. aureus
strains.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-017-2518-y</identifier><identifier>PMID: 29238856</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Animals ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Antimicrobial Cationic Peptides - chemical synthesis ; Antimicrobial Cationic Peptides - pharmacology ; Antimicrobial peptides ; Bacteria ; Biochemical Engineering ; Biochemistry ; Biomedical and Life Sciences ; Cytotoxicity ; Drug resistance ; Endotoxins - antagonists & inhibitors ; Endotoxins - biosynthesis ; Gram-negative bacteria ; Gram-Negative Bacteria - drug effects ; Gram-positive bacteria ; Gram-Positive Bacteria - drug effects ; Humans ; Immunodeficiency ; Immunologic Deficiency Syndromes - drug therapy ; Immunologic Deficiency Syndromes - immunology ; Immunologic Deficiency Syndromes - microbiology ; Immunologic Deficiency Syndromes - pathology ; Immunosuppressive agents ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - immunology ; Inflammation - microbiology ; Life Sciences ; Lipopolysaccharides - toxicity ; Lipoteichoic acid ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - pathogenicity ; Mice ; Morbidity ; Multidrug resistance ; Neurobiology ; Neutralizing ; Original Article ; Peptides ; Proteomics ; RAW 264.7 Cells ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - pathology ; Staphylococcus aureus ; Strains (organisms) ; Teichoic Acids - toxicity ; Toxicity</subject><ispartof>Amino acids, 2018-04, Vol.50 (3-4), p.363-372</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2017</rights><rights>Amino Acids is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-136c764f3fbe69cff94242a39e122f0e68b8e5c7aa49bfd42eed82f2a9109143</citedby><cites>FETCH-LOGICAL-c372t-136c764f3fbe69cff94242a39e122f0e68b8e5c7aa49bfd42eed82f2a9109143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00726-017-2518-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00726-017-2518-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29238856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jong-kook</creatorcontrib><creatorcontrib>Park, Yoonkyung</creatorcontrib><title>Anti-endotoxin mechanism of the KW4 peptide in inflammation in RAW 264.7 cells induced by LTA and drug-resistant Staphylococcus aureus 1630</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><addtitle>Amino Acids</addtitle><description>Drug-resistant microorganism infections cause serious disease and can lead to mortality and morbidity. In particular,
Staphylococcus aureus
induces pyrogenic and toxigenic infections, and drug-resistance occurs rapidly. Multidrug-resistant
S. aureus
, such as methicillin-resistant
S. aureus
and methicillin-sensitive
S. aureus
, can also cause immunodeficiency and immune deficiency syndrome from lipoteichoic acid. However, antimicrobial peptides, such as KW4, have strong antimicrobial activity, low cytotoxicity, and high neutralization activity against endotoxin substances from Gram-negative bacteria. The objective of this study was to use a synthetic KW4 antimicrobial peptide to evaluate the inhibition of drug-resistance development, antimicrobial activity, and neutralizing activity in
S. aureus
Gram-positive bacteria. The KW4 peptide showed strong antimicrobial activity against drug-resistant
S. aureus
strains and significantly increased the anti-neutralizing activity of lipoteichoic acid in
S. aureus
1630 drug-resistant bacteria. In addition,
S. aureus
ATCC 29213 did not develop resistance to KW4 as with other antibiotic drugs. These results suggest that the KW4 peptide is an effective antibiotic and anti-neutralizing agent against multidrug-resistant
S. aureus
strains.</description><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial Cationic Peptides - chemical synthesis</subject><subject>Antimicrobial Cationic Peptides - pharmacology</subject><subject>Antimicrobial peptides</subject><subject>Bacteria</subject><subject>Biochemical Engineering</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cytotoxicity</subject><subject>Drug resistance</subject><subject>Endotoxins - antagonists & inhibitors</subject><subject>Endotoxins - biosynthesis</subject><subject>Gram-negative bacteria</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-positive bacteria</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Immunologic Deficiency Syndromes - drug therapy</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Immunologic Deficiency Syndromes - microbiology</subject><subject>Immunologic Deficiency Syndromes - pathology</subject><subject>Immunosuppressive agents</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - immunology</subject><subject>Inflammation - microbiology</subject><subject>Life Sciences</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Lipoteichoic acid</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Methicillin-Resistant Staphylococcus aureus - pathogenicity</subject><subject>Mice</subject><subject>Morbidity</subject><subject>Multidrug resistance</subject><subject>Neurobiology</subject><subject>Neutralizing</subject><subject>Original Article</subject><subject>Peptides</subject><subject>Proteomics</subject><subject>RAW 264.7 Cells</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - immunology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - pathology</subject><subject>Staphylococcus aureus</subject><subject>Strains (organisms)</subject><subject>Teichoic Acids - toxicity</subject><subject>Toxicity</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM9q3DAQxkVpaLZJH6CXIuhZqSRrZeu4hP6jC4VkIUchS6Osgy25kgz1M_Slq2XT0ksvM8zMN98MP4TeMnrDKG0_5Bq4JJS1hG9ZR9YXaMNE0xHOlHqJNlQ1igixZZfodc5PlDLeMfkKXXLFm67byg36tQtlIBBcLPHnEPAE9mjCkCccPS5HwN8eBJ5hLoMDXOdD8KOZJlOGeCrw3e4BcyluWmxhHHNtucWCw_2K94cdNsFhl5ZHkiAPuZhQ8H0x83Edo43WLhmbJUFNTDb0Gl14M2Z485yv0OHTx8PtF7L__vnr7W5PbNPyQlgjbSuFb3wPUlnvleCCm0YB49xTkF3fwda2xgjVeyc4gOu450YxqiqeK_T-bDun-GOBXPRTXFKoFzVTbf2DNryrKnZW2RRzTuD1nIbJpFUzqk_09Zm-rvT1ib5e6867Z-eln8D93fiDuwr4WZDrKDxC-uf0f11_A0_pj-Y</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Lee, Jong-kook</creator><creator>Park, Yoonkyung</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180401</creationdate><title>Anti-endotoxin mechanism of the KW4 peptide in inflammation in RAW 264.7 cells induced by LTA and drug-resistant Staphylococcus aureus 1630</title><author>Lee, Jong-kook ; Park, Yoonkyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-136c764f3fbe69cff94242a39e122f0e68b8e5c7aa49bfd42eed82f2a9109143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial Cationic Peptides - chemical synthesis</topic><topic>Antimicrobial Cationic Peptides - pharmacology</topic><topic>Antimicrobial peptides</topic><topic>Bacteria</topic><topic>Biochemical Engineering</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cytotoxicity</topic><topic>Drug resistance</topic><topic>Endotoxins - antagonists & inhibitors</topic><topic>Endotoxins - biosynthesis</topic><topic>Gram-negative bacteria</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-positive bacteria</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Immunologic Deficiency Syndromes - drug therapy</topic><topic>Immunologic Deficiency Syndromes - immunology</topic><topic>Immunologic Deficiency Syndromes - microbiology</topic><topic>Immunologic Deficiency Syndromes - pathology</topic><topic>Immunosuppressive agents</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - immunology</topic><topic>Inflammation - microbiology</topic><topic>Life Sciences</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Lipoteichoic acid</topic><topic>Methicillin</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Methicillin-Resistant Staphylococcus aureus - pathogenicity</topic><topic>Mice</topic><topic>Morbidity</topic><topic>Multidrug resistance</topic><topic>Neurobiology</topic><topic>Neutralizing</topic><topic>Original Article</topic><topic>Peptides</topic><topic>Proteomics</topic><topic>RAW 264.7 Cells</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - immunology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - pathology</topic><topic>Staphylococcus aureus</topic><topic>Strains (organisms)</topic><topic>Teichoic Acids - toxicity</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jong-kook</creatorcontrib><creatorcontrib>Park, Yoonkyung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Amino acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jong-kook</au><au>Park, Yoonkyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-endotoxin mechanism of the KW4 peptide in inflammation in RAW 264.7 cells induced by LTA and drug-resistant Staphylococcus aureus 1630</atitle><jtitle>Amino acids</jtitle><stitle>Amino Acids</stitle><addtitle>Amino Acids</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>50</volume><issue>3-4</issue><spage>363</spage><epage>372</epage><pages>363-372</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><abstract>Drug-resistant microorganism infections cause serious disease and can lead to mortality and morbidity. In particular,
Staphylococcus aureus
induces pyrogenic and toxigenic infections, and drug-resistance occurs rapidly. Multidrug-resistant
S. aureus
, such as methicillin-resistant
S. aureus
and methicillin-sensitive
S. aureus
, can also cause immunodeficiency and immune deficiency syndrome from lipoteichoic acid. However, antimicrobial peptides, such as KW4, have strong antimicrobial activity, low cytotoxicity, and high neutralization activity against endotoxin substances from Gram-negative bacteria. The objective of this study was to use a synthetic KW4 antimicrobial peptide to evaluate the inhibition of drug-resistance development, antimicrobial activity, and neutralizing activity in
S. aureus
Gram-positive bacteria. The KW4 peptide showed strong antimicrobial activity against drug-resistant
S. aureus
strains and significantly increased the anti-neutralizing activity of lipoteichoic acid in
S. aureus
1630 drug-resistant bacteria. In addition,
S. aureus
ATCC 29213 did not develop resistance to KW4 as with other antibiotic drugs. These results suggest that the KW4 peptide is an effective antibiotic and anti-neutralizing agent against multidrug-resistant
S. aureus
strains.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>29238856</pmid><doi>10.1007/s00726-017-2518-y</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-4451 |
| ispartof | Amino acids, 2018-04, Vol.50 (3-4), p.363-372 |
| issn | 0939-4451 1438-2199 |
| language | eng |
| recordid | cdi_proquest_journals_1976300328 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Analytical Chemistry Animals Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Bacteria Biochemical Engineering Biochemistry Biomedical and Life Sciences Cytotoxicity Drug resistance Endotoxins - antagonists & inhibitors Endotoxins - biosynthesis Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-positive bacteria Gram-Positive Bacteria - drug effects Humans Immunodeficiency Immunologic Deficiency Syndromes - drug therapy Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - microbiology Immunologic Deficiency Syndromes - pathology Immunosuppressive agents Inflammation - chemically induced Inflammation - drug therapy Inflammation - immunology Inflammation - microbiology Life Sciences Lipopolysaccharides - toxicity Lipoteichoic acid Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - pathogenicity Mice Morbidity Multidrug resistance Neurobiology Neutralizing Original Article Peptides Proteomics RAW 264.7 Cells Staphylococcal Infections - drug therapy Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus Strains (organisms) Teichoic Acids - toxicity Toxicity |
| title | Anti-endotoxin mechanism of the KW4 peptide in inflammation in RAW 264.7 cells induced by LTA and drug-resistant Staphylococcus aureus 1630 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T21%3A51%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-endotoxin%20mechanism%20of%20the%20KW4%20peptide%20in%20inflammation%20in%20RAW%20264.7%20cells%20induced%20by%20LTA%20and%20drug-resistant%20Staphylococcus%20aureus%201630&rft.jtitle=Amino%20acids&rft.au=Lee,%20Jong-kook&rft.date=2018-04-01&rft.volume=50&rft.issue=3-4&rft.spage=363&rft.epage=372&rft.pages=363-372&rft.issn=0939-4451&rft.eissn=1438-2199&rft_id=info:doi/10.1007/s00726-017-2518-y&rft_dat=%3Cproquest_cross%3E1976300328%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1976300328&rft_id=info:pmid/29238856&rfr_iscdi=true |