Association of cortical β-amyloid with erythrocyte membrane monounsaturated and saturated fatty acids in older adults at risk of dementia
Objectives We examined the relationships between erythrocyte membrane monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) and cortical β-amyloid (Aβ) load in older adults reporting subjective memory complaints. Design This is a cross-sectional study using data from the Multidomain A...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2017-12, Vol.21 (10), p.1170-1175 |
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| creator | Hooper, Claudie de Souto Barreto, P. Payoux, P. Salabert, A. S. Guyonnet, S. Andrieu, S. Sourdet, S. Delrieu, J. Vellas, B. |
| description | Objectives
We examined the relationships between erythrocyte membrane monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) and cortical β-amyloid (Aβ) load in older adults reporting subjective memory complaints.
Design
This is a cross-sectional study using data from the Multidomain Alzheimer Preventive Trial (MAPT); a randomised controlled trial.
Setting
French community dwellers aged 70 or over reporting subjective memory complaints, but free from a diagnosis of clinical dementia.
Participants
Participants of this study were 61 individuals from the placebo arm of the MAPT trial with data on erythrocyte membrane fatty acid levels and cortical Aβ load.
Measurements
Cortical-to-cerebellar standard uptake value ratios were assessed using [18F] florbetapir positron emission tomography (PET). Fatty acids were measured in erythrocyte cell membranes using gas chromatography. Associations between erythrocyte membrane MUFAs and SFAs and cortical Aβ load were explored using adjusted multiple linear regression models and were considered significant at p ≤ 0.005 (10 comparisons) after correction for multiple testing.
Results
We found no significant associations between fatty acids and cortical Aβ load using multiple linear regression adjusted for age, sex, education, cognition, PET-scan to clinical assessment interval, PET-scan to blood collection interval and apolipoprotein E (ApoE) status. The association closest to significance was that between erythrocyte membrane stearic acid and Aβ (B-coefficient 0.03, 95 % CI: 0.00,0.05, p = 0.05). This association, although statistically non-significant, appeared to be stronger amongst ApoE ε4 carriers (B-coefficient 0.04, 95 % CI: -0.01,0.09, p = 0.08) compared to ApoE ε4 non-carriers (B-coefficient 0.02, 95 % CI: -0.01,0.05, p = 0.18) in age and sex stratified analysis.
Conclusion
Future research in the form of large longitudinal observational study is needed to validate our findings, particularly regarding the potential association of stearic acid with cortical Aβ. |
| doi_str_mv | 10.1007/s12603-017-0975-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1975528969</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1975528969</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-4b5838114cc91f6d18589070e828a2d49356680d09fcba24518607a58f38be8d3</originalsourceid><addsrcrecordid>eNp1kMtu1jAQhS0Eohd4ADbIEmsXO4nt8bKqKCBVYgNra2I71CWJi-0I5RV4HB6EZ8K__nLZsJozmjPnSB8hLwS_EJzr10V0iveMC8240ZL1j8ip0IqzQQM8brrThmnN9Qk5K-WO80EaUE_JSWcEAGh1Sr5flpJcxBrTStNEXco1Opzpzx8Ml31O0dNvsd7SkPd6m5Pba6BLWMaMaxNpTdtasG4Za_AUV0__bhPWulN00RcaW_rsQ6bot7kWipXmWL4cKn1YwlojPiNPJpxLeP4wz8mn6zcfr96xmw9v319d3jA3CFnZMEroQYjBOSMm5QVIMFzzAB1g5wfTS6WAe24mN2I3SAGKa5Qw9TAG8P05eXXMvc_p6xZKtXdpy2urtKJRlB0YZZpLHF0up1JymOx9jgvm3QpuD_Ttkb5t9O2Bvu3bz8uH5G1cgv_z8Rt3M3RHQ2mn9XPI_1T_N_UX89qSWg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1975528969</pqid></control><display><type>article</type><title>Association of cortical β-amyloid with erythrocyte membrane monounsaturated and saturated fatty acids in older adults at risk of dementia</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Alma/SFX Local Collection</source><creator>Hooper, Claudie ; de Souto Barreto, P. ; Payoux, P. ; Salabert, A. S. ; Guyonnet, S. ; Andrieu, S. ; Sourdet, S. ; Delrieu, J. ; Vellas, B.</creator><creatorcontrib>Hooper, Claudie ; de Souto Barreto, P. ; Payoux, P. ; Salabert, A. S. ; Guyonnet, S. ; Andrieu, S. ; Sourdet, S. ; Delrieu, J. ; Vellas, B.</creatorcontrib><description>Objectives
We examined the relationships between erythrocyte membrane monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) and cortical β-amyloid (Aβ) load in older adults reporting subjective memory complaints.
Design
This is a cross-sectional study using data from the Multidomain Alzheimer Preventive Trial (MAPT); a randomised controlled trial.
Setting
French community dwellers aged 70 or over reporting subjective memory complaints, but free from a diagnosis of clinical dementia.
Participants
Participants of this study were 61 individuals from the placebo arm of the MAPT trial with data on erythrocyte membrane fatty acid levels and cortical Aβ load.
Measurements
Cortical-to-cerebellar standard uptake value ratios were assessed using [18F] florbetapir positron emission tomography (PET). Fatty acids were measured in erythrocyte cell membranes using gas chromatography. Associations between erythrocyte membrane MUFAs and SFAs and cortical Aβ load were explored using adjusted multiple linear regression models and were considered significant at p ≤ 0.005 (10 comparisons) after correction for multiple testing.
Results
We found no significant associations between fatty acids and cortical Aβ load using multiple linear regression adjusted for age, sex, education, cognition, PET-scan to clinical assessment interval, PET-scan to blood collection interval and apolipoprotein E (ApoE) status. The association closest to significance was that between erythrocyte membrane stearic acid and Aβ (B-coefficient 0.03, 95 % CI: 0.00,0.05, p = 0.05). This association, although statistically non-significant, appeared to be stronger amongst ApoE ε4 carriers (B-coefficient 0.04, 95 % CI: -0.01,0.09, p = 0.08) compared to ApoE ε4 non-carriers (B-coefficient 0.02, 95 % CI: -0.01,0.05, p = 0.18) in age and sex stratified analysis.
Conclusion
Future research in the form of large longitudinal observational study is needed to validate our findings, particularly regarding the potential association of stearic acid with cortical Aβ.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-017-0975-3</identifier><identifier>PMID: 29188876</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Aged ; Aging ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Amyloid beta-Peptides - metabolism ; Cross-Sectional Studies ; Dementia ; Dementia - diagnosis ; Erythrocyte Membrane - metabolism ; Erythrocyte Membrane - pathology ; Erythrocytes ; Fatty acids ; Fatty Acids - adverse effects ; Fatty Acids - metabolism ; Female ; Geriatrics/Gerontology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Neurosciences ; Nutrition ; Older people ; Primary Care Medicine ; Quality of Life Research</subject><ispartof>The Journal of nutrition, health & aging, 2017-12, Vol.21 (10), p.1170-1175</ispartof><rights>Serdi and Springer-Verlag France SAS 2017</rights><rights>The journal of nutrition, health & aging is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-4b5838114cc91f6d18589070e828a2d49356680d09fcba24518607a58f38be8d3</citedby><cites>FETCH-LOGICAL-c415t-4b5838114cc91f6d18589070e828a2d49356680d09fcba24518607a58f38be8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-017-0975-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-017-0975-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29188876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hooper, Claudie</creatorcontrib><creatorcontrib>de Souto Barreto, P.</creatorcontrib><creatorcontrib>Payoux, P.</creatorcontrib><creatorcontrib>Salabert, A. S.</creatorcontrib><creatorcontrib>Guyonnet, S.</creatorcontrib><creatorcontrib>Andrieu, S.</creatorcontrib><creatorcontrib>Sourdet, S.</creatorcontrib><creatorcontrib>Delrieu, J.</creatorcontrib><creatorcontrib>Vellas, B.</creatorcontrib><title>Association of cortical β-amyloid with erythrocyte membrane monounsaturated and saturated fatty acids in older adults at risk of dementia</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objectives
We examined the relationships between erythrocyte membrane monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) and cortical β-amyloid (Aβ) load in older adults reporting subjective memory complaints.
Design
This is a cross-sectional study using data from the Multidomain Alzheimer Preventive Trial (MAPT); a randomised controlled trial.
Setting
French community dwellers aged 70 or over reporting subjective memory complaints, but free from a diagnosis of clinical dementia.
Participants
Participants of this study were 61 individuals from the placebo arm of the MAPT trial with data on erythrocyte membrane fatty acid levels and cortical Aβ load.
Measurements
Cortical-to-cerebellar standard uptake value ratios were assessed using [18F] florbetapir positron emission tomography (PET). Fatty acids were measured in erythrocyte cell membranes using gas chromatography. Associations between erythrocyte membrane MUFAs and SFAs and cortical Aβ load were explored using adjusted multiple linear regression models and were considered significant at p ≤ 0.005 (10 comparisons) after correction for multiple testing.
Results
We found no significant associations between fatty acids and cortical Aβ load using multiple linear regression adjusted for age, sex, education, cognition, PET-scan to clinical assessment interval, PET-scan to blood collection interval and apolipoprotein E (ApoE) status. The association closest to significance was that between erythrocyte membrane stearic acid and Aβ (B-coefficient 0.03, 95 % CI: 0.00,0.05, p = 0.05). This association, although statistically non-significant, appeared to be stronger amongst ApoE ε4 carriers (B-coefficient 0.04, 95 % CI: -0.01,0.09, p = 0.08) compared to ApoE ε4 non-carriers (B-coefficient 0.02, 95 % CI: -0.01,0.05, p = 0.18) in age and sex stratified analysis.
Conclusion
Future research in the form of large longitudinal observational study is needed to validate our findings, particularly regarding the potential association of stearic acid with cortical Aβ.</description><subject>Aged</subject><subject>Aging</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Dementia</subject><subject>Dementia - diagnosis</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocyte Membrane - pathology</subject><subject>Erythrocytes</subject><subject>Fatty acids</subject><subject>Fatty Acids - adverse effects</subject><subject>Fatty Acids - metabolism</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Older people</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kMtu1jAQhS0Eohd4ADbIEmsXO4nt8bKqKCBVYgNra2I71CWJi-0I5RV4HB6EZ8K__nLZsJozmjPnSB8hLwS_EJzr10V0iveMC8240ZL1j8ip0IqzQQM8brrThmnN9Qk5K-WO80EaUE_JSWcEAGh1Sr5flpJcxBrTStNEXco1Opzpzx8Ml31O0dNvsd7SkPd6m5Pba6BLWMaMaxNpTdtasG4Za_AUV0__bhPWulN00RcaW_rsQ6bot7kWipXmWL4cKn1YwlojPiNPJpxLeP4wz8mn6zcfr96xmw9v319d3jA3CFnZMEroQYjBOSMm5QVIMFzzAB1g5wfTS6WAe24mN2I3SAGKa5Qw9TAG8P05eXXMvc_p6xZKtXdpy2urtKJRlB0YZZpLHF0up1JymOx9jgvm3QpuD_Ttkb5t9O2Bvu3bz8uH5G1cgv_z8Rt3M3RHQ2mn9XPI_1T_N_UX89qSWg</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Hooper, Claudie</creator><creator>de Souto Barreto, P.</creator><creator>Payoux, P.</creator><creator>Salabert, A. S.</creator><creator>Guyonnet, S.</creator><creator>Andrieu, S.</creator><creator>Sourdet, S.</creator><creator>Delrieu, J.</creator><creator>Vellas, B.</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20171201</creationdate><title>Association of cortical β-amyloid with erythrocyte membrane monounsaturated and saturated fatty acids in older adults at risk of dementia</title><author>Hooper, Claudie ; de Souto Barreto, P. ; Payoux, P. ; Salabert, A. S. ; Guyonnet, S. ; Andrieu, S. ; Sourdet, S. ; Delrieu, J. ; Vellas, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-4b5838114cc91f6d18589070e828a2d49356680d09fcba24518607a58f38be8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Dementia</topic><topic>Dementia - diagnosis</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocyte Membrane - pathology</topic><topic>Erythrocytes</topic><topic>Fatty acids</topic><topic>Fatty Acids - adverse effects</topic><topic>Fatty Acids - metabolism</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Older people</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hooper, Claudie</creatorcontrib><creatorcontrib>de Souto Barreto, P.</creatorcontrib><creatorcontrib>Payoux, P.</creatorcontrib><creatorcontrib>Salabert, A. S.</creatorcontrib><creatorcontrib>Guyonnet, S.</creatorcontrib><creatorcontrib>Andrieu, S.</creatorcontrib><creatorcontrib>Sourdet, S.</creatorcontrib><creatorcontrib>Delrieu, J.</creatorcontrib><creatorcontrib>Vellas, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hooper, Claudie</au><au>de Souto Barreto, P.</au><au>Payoux, P.</au><au>Salabert, A. S.</au><au>Guyonnet, S.</au><au>Andrieu, S.</au><au>Sourdet, S.</au><au>Delrieu, J.</au><au>Vellas, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of cortical β-amyloid with erythrocyte membrane monounsaturated and saturated fatty acids in older adults at risk of dementia</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>21</volume><issue>10</issue><spage>1170</spage><epage>1175</epage><pages>1170-1175</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objectives
We examined the relationships between erythrocyte membrane monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) and cortical β-amyloid (Aβ) load in older adults reporting subjective memory complaints.
Design
This is a cross-sectional study using data from the Multidomain Alzheimer Preventive Trial (MAPT); a randomised controlled trial.
Setting
French community dwellers aged 70 or over reporting subjective memory complaints, but free from a diagnosis of clinical dementia.
Participants
Participants of this study were 61 individuals from the placebo arm of the MAPT trial with data on erythrocyte membrane fatty acid levels and cortical Aβ load.
Measurements
Cortical-to-cerebellar standard uptake value ratios were assessed using [18F] florbetapir positron emission tomography (PET). Fatty acids were measured in erythrocyte cell membranes using gas chromatography. Associations between erythrocyte membrane MUFAs and SFAs and cortical Aβ load were explored using adjusted multiple linear regression models and were considered significant at p ≤ 0.005 (10 comparisons) after correction for multiple testing.
Results
We found no significant associations between fatty acids and cortical Aβ load using multiple linear regression adjusted for age, sex, education, cognition, PET-scan to clinical assessment interval, PET-scan to blood collection interval and apolipoprotein E (ApoE) status. The association closest to significance was that between erythrocyte membrane stearic acid and Aβ (B-coefficient 0.03, 95 % CI: 0.00,0.05, p = 0.05). This association, although statistically non-significant, appeared to be stronger amongst ApoE ε4 carriers (B-coefficient 0.04, 95 % CI: -0.01,0.09, p = 0.08) compared to ApoE ε4 non-carriers (B-coefficient 0.02, 95 % CI: -0.01,0.05, p = 0.18) in age and sex stratified analysis.
Conclusion
Future research in the form of large longitudinal observational study is needed to validate our findings, particularly regarding the potential association of stearic acid with cortical Aβ.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>29188876</pmid><doi>10.1007/s12603-017-0975-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2017-12, Vol.21 (10), p.1170-1175 |
| issn | 1279-7707 1760-4788 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals; Alma/SFX Local Collection |
| subjects | Aged Aging Alzheimer Disease - diagnosis Alzheimer's disease Amyloid beta-Peptides - metabolism Cross-Sectional Studies Dementia Dementia - diagnosis Erythrocyte Membrane - metabolism Erythrocyte Membrane - pathology Erythrocytes Fatty acids Fatty Acids - adverse effects Fatty Acids - metabolism Female Geriatrics/Gerontology Humans Male Medicine Medicine & Public Health Neurosciences Nutrition Older people Primary Care Medicine Quality of Life Research |
| title | Association of cortical β-amyloid with erythrocyte membrane monounsaturated and saturated fatty acids in older adults at risk of dementia |
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