Genistein, Daidzein and Glycitein Inhibit Growth and DNA Synthesis of Aortic Smooth Muscle Cells from Stroke-Prone Spontaneously Hypertensive Rats

Recent studies have reported that estrogen replacement therapy (ERT) reduces the risk of cardiovascular diseases in postmenopausal women. However, mechanisms responsible for this effect are not yet completely understood, and ERT is associated with carcinogenic side effects in women and feminizing ef...

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Veröffentlicht in:	The Journal of nutrition 2001-04, Vol.131 (4), p.1154-1158
Hauptverfasser:	Pan, Weijun, Ikeda, Katsumi, Takebe, Minoru, Yamori, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Aorta - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Division - drug effects Cells, Cultured daidzein Deoxyribonucleic acid Disease Susceptibility DNA DNA - antagonists & inhibitors DNA - biosynthesis Drug therapy Estrogens genistein Genistein - pharmacology Glycine max - chemistry glycitein Growth Inhibitors - pharmacology Heart Hypertension Hypertension - complications Hypertension - metabolism Hypertension - pathology isoflavone Isoflavones - pharmacology Medical sciences Muscle, Smooth - metabolism Muscle, Smooth - pathology Physical growth Rats Rats, Inbred SHR - anatomy & histology Rats, Inbred SHR - physiology Rats, Inbred WKY Rodents smooth muscle cells Stroke Stroke - etiology
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