Diallyl disulfide suppresses the growth of human colon tumor cell xenografts in athymic nude mice

The present studies examined the anti-proliferative effects of diallyl disulfide (DADS) on the growth of human colon tumor cell line, HCT-15, xenografts in 6-wk-old female NCr nu/nu mice with an initial body weight of 20-22 g. Intraperitoneal injection of 1 mg DADS thrice weekly reduced tumor volume...

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Veröffentlicht in:	The Journal of nutrition 1996-05, Vol.126 (5), p.1355-1361
Hauptverfasser:	SUNDARAM, S. G, MILNER, J. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Allyl Compounds Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biochemistry Biological and medical sciences Body Weight - drug effects Carcinogenesis, carcinogens and anticarcinogens Cell Division - drug effects Cellular biology Colon Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Disulfides - administration & dosage Disulfides - pharmacology Disulfides - therapeutic use Dose-Response Relationship, Drug Drug Synergism Female Fluorouracil - administration & dosage Fluorouracil - pharmacology Fluorouracil - therapeutic use Foods and miscellaneous Humans Injections, Intraperitoneal Leukocytes Medical sciences Mice Mice, Nude Neoplasm Transplantation Plant Oils - administration & dosage Plant Oils - pharmacology Plant Oils - therapeutic use Rodents Transplantation, Heterologous Tumor Cells, Cultured Tumors Urea - blood
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