Homocysteine, EDRF and Endothelial function
Nitric oxide, a heterodiatomic molecule, serves as an endothelium-dependent vasodilator and an antithrombotic agent in the vasculature. Because of its reactivity under physiological conditions, accumulating data suggest that nitric oxide forms adducts with several classes of biologic compounds, one...
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition 1996-04, Vol.126 (45), p.1290S-1294S |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1294S |
|---|---|
| container_issue | 45 |
| container_start_page | 1290S |
| container_title | The Journal of nutrition |
| container_volume | 126 |
| creator | Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.) Welch, G.N Loscalzo, J |
| description | Nitric oxide, a heterodiatomic molecule, serves as an endothelium-dependent vasodilator and an antithrombotic agent in the vasculature. Because of its reactivity under physiological conditions, accumulating data suggest that nitric oxide forms adducts with several classes of biologic compounds, one of which is the sulfhydryl functionality, to form thionitrites or S-nitrosothiols. In this overview, we will examine the effects of S-nitrosothiols in the vascular system as modulators of tone and inhibitors of platelet activation to understand better what role these compounds may play in physiological and pathological states. With this background, we will review the role nitric oxide (EDRF) plays in helping to ameliorate vascular injury by homocysteine |
| doi_str_mv | 10.1093/jn/126.suppl_4.1290s |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_197428013</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022316622017709</els_id><sourcerecordid>9448775</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-59d08b30b41964df026c4147043c117d6b88e0fe16739daacf8db3287bcd1dea3</originalsourceid><addsrcrecordid>eNp9kF1LKzEQhoMonvrxDzxQvNWtM0maTW4EqfUDBMGP65BNsp6UNqnJruC_d6XleOfVXDzzvjM8hJwgTBAUu1jEC6RiUvr1eqn5BKmCskNGOOVYCQTYJSMASiuGQvwhB6UsAAC5kvtkXwpOec1G5OwurZL9LJ0P0Z-P59dPN2MT3XgeXer--WUwy3HbR9uFFI_IXmuWxR9v5yF5vZm_zO6qh8fb-9nVQ2WnHLpqqhzIhkHDUQnuWqDCcuQ1cGYRaycaKT20HkXNlDPGttI1jMq6sQ6dN-yQnG561zm99750epH6HIeTGlXNqQRkwxLfLNmcSsm-1escViZ_agT97Ucvoh786K0f_e3neYj93Xb3zcq7_6GtkB_emqTNWw5Fvz6jUjVMFZXiNy4oh4FfbrgfBH0En3WxwUfrXcjedtql8PuDXwDSiPE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197428013</pqid></control><display><type>article</type><title>Homocysteine, EDRF and Endothelial function</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.) ; Welch, G.N ; Loscalzo, J</creator><creatorcontrib>Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.) ; Welch, G.N ; Loscalzo, J</creatorcontrib><description>Nitric oxide, a heterodiatomic molecule, serves as an endothelium-dependent vasodilator and an antithrombotic agent in the vasculature. Because of its reactivity under physiological conditions, accumulating data suggest that nitric oxide forms adducts with several classes of biologic compounds, one of which is the sulfhydryl functionality, to form thionitrites or S-nitrosothiols. In this overview, we will examine the effects of S-nitrosothiols in the vascular system as modulators of tone and inhibitors of platelet activation to understand better what role these compounds may play in physiological and pathological states. With this background, we will review the role nitric oxide (EDRF) plays in helping to ameliorate vascular injury by homocysteine</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/126.suppl_4.1290s</identifier><identifier>PMID: 8642473</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ADHESION ; Amino acids ; Animals ; Biochemistry ; BLOOD CIRCULATION ; BLOOD COAGULATION ; BLOOD COAGULATION FACTORS ; BLOOD PLASMA ; BLOOD PROTEINS ; Blood vessels ; CARDIOVASCULAR SYSTEM ; CIRCULACION SANGUINEA ; CIRCULATION SANGUINE ; COAGULACION SANGUINEA ; COAGULATION SANGUINE ; COMPOSE NITROSE ; COMPUESTOS NITROSOS ; endothelial function ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; ENDOTHELIUM-DERIVED RELAXING FACTOR ; HOMOCISTEINA ; HOMOCYSTEINE ; Homocysteine - toxicity ; Humans ; MECHANICAL PROPERTIES ; Mercaptoethanol ; Metabolism ; NITRIC OXIDE ; Nitric Oxide - physiology ; NITROSO COMPOUNDS ; Nitroso Compounds - pharmacology ; OXIDO NITRICO ; OXYDE NITRIQUE ; PLASMA SANGUIN ; PLASMA SANGUINEO ; Platelet Adhesiveness - drug effects ; PLATELET AGGREGATION ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; PLATELETS ; PROPIEDADES MECANICAS ; PROPRIETE MECANIQUE ; PROTEINAS SANGUINEAS ; PROTEINE SANGUINE ; RATIOS ; REVIEWS ; RSNOS ; S-Nitrosothiols ; SISTEMA CARDIOVASCULAR ; SYSTEME CARDIOVASCULAIRE ; THIOL ; THIOLS ; THROMBOCYTE ; TIOLES ; TROMBOCITOS ; VASCULAR TONE ; VASODILATION</subject><ispartof>The Journal of nutrition, 1996-04, Vol.126 (45), p.1290S-1294S</ispartof><rights>1996 American Society for Nutrition.</rights><rights>Copyright American Institute of Nutrition Apr 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-59d08b30b41964df026c4147043c117d6b88e0fe16739daacf8db3287bcd1dea3</citedby><cites>FETCH-LOGICAL-c540t-59d08b30b41964df026c4147043c117d6b88e0fe16739daacf8db3287bcd1dea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8642473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.)</creatorcontrib><creatorcontrib>Welch, G.N</creatorcontrib><creatorcontrib>Loscalzo, J</creatorcontrib><title>Homocysteine, EDRF and Endothelial function</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Nitric oxide, a heterodiatomic molecule, serves as an endothelium-dependent vasodilator and an antithrombotic agent in the vasculature. Because of its reactivity under physiological conditions, accumulating data suggest that nitric oxide forms adducts with several classes of biologic compounds, one of which is the sulfhydryl functionality, to form thionitrites or S-nitrosothiols. In this overview, we will examine the effects of S-nitrosothiols in the vascular system as modulators of tone and inhibitors of platelet activation to understand better what role these compounds may play in physiological and pathological states. With this background, we will review the role nitric oxide (EDRF) plays in helping to ameliorate vascular injury by homocysteine</description><subject>ADHESION</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>BLOOD CIRCULATION</subject><subject>BLOOD COAGULATION</subject><subject>BLOOD COAGULATION FACTORS</subject><subject>BLOOD PLASMA</subject><subject>BLOOD PROTEINS</subject><subject>Blood vessels</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CIRCULACION SANGUINEA</subject><subject>CIRCULATION SANGUINE</subject><subject>COAGULACION SANGUINEA</subject><subject>COAGULATION SANGUINE</subject><subject>COMPOSE NITROSE</subject><subject>COMPUESTOS NITROSOS</subject><subject>endothelial function</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>ENDOTHELIUM-DERIVED RELAXING FACTOR</subject><subject>HOMOCISTEINA</subject><subject>HOMOCYSTEINE</subject><subject>Homocysteine - toxicity</subject><subject>Humans</subject><subject>MECHANICAL PROPERTIES</subject><subject>Mercaptoethanol</subject><subject>Metabolism</subject><subject>NITRIC OXIDE</subject><subject>Nitric Oxide - physiology</subject><subject>NITROSO COMPOUNDS</subject><subject>Nitroso Compounds - pharmacology</subject><subject>OXIDO NITRICO</subject><subject>OXYDE NITRIQUE</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>Platelet Adhesiveness - drug effects</subject><subject>PLATELET AGGREGATION</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>PLATELETS</subject><subject>PROPIEDADES MECANICAS</subject><subject>PROPRIETE MECANIQUE</subject><subject>PROTEINAS SANGUINEAS</subject><subject>PROTEINE SANGUINE</subject><subject>RATIOS</subject><subject>REVIEWS</subject><subject>RSNOS</subject><subject>S-Nitrosothiols</subject><subject>SISTEMA CARDIOVASCULAR</subject><subject>SYSTEME CARDIOVASCULAIRE</subject><subject>THIOL</subject><subject>THIOLS</subject><subject>THROMBOCYTE</subject><subject>TIOLES</subject><subject>TROMBOCITOS</subject><subject>VASCULAR TONE</subject><subject>VASODILATION</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LKzEQhoMonvrxDzxQvNWtM0maTW4EqfUDBMGP65BNsp6UNqnJruC_d6XleOfVXDzzvjM8hJwgTBAUu1jEC6RiUvr1eqn5BKmCskNGOOVYCQTYJSMASiuGQvwhB6UsAAC5kvtkXwpOec1G5OwurZL9LJ0P0Z-P59dPN2MT3XgeXer--WUwy3HbR9uFFI_IXmuWxR9v5yF5vZm_zO6qh8fb-9nVQ2WnHLpqqhzIhkHDUQnuWqDCcuQ1cGYRaycaKT20HkXNlDPGttI1jMq6sQ6dN-yQnG561zm99750epH6HIeTGlXNqQRkwxLfLNmcSsm-1escViZ_agT97Ucvoh786K0f_e3neYj93Xb3zcq7_6GtkB_emqTNWw5Fvz6jUjVMFZXiNy4oh4FfbrgfBH0En3WxwUfrXcjedtql8PuDXwDSiPE</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.)</creator><creator>Welch, G.N</creator><creator>Loscalzo, J</creator><general>Elsevier Inc</general><general>American Institute of Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>19960401</creationdate><title>Homocysteine, EDRF and Endothelial function</title><author>Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.) ; Welch, G.N ; Loscalzo, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-59d08b30b41964df026c4147043c117d6b88e0fe16739daacf8db3287bcd1dea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>ADHESION</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>BLOOD CIRCULATION</topic><topic>BLOOD COAGULATION</topic><topic>BLOOD COAGULATION FACTORS</topic><topic>BLOOD PLASMA</topic><topic>BLOOD PROTEINS</topic><topic>Blood vessels</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CIRCULACION SANGUINEA</topic><topic>CIRCULATION SANGUINE</topic><topic>COAGULACION SANGUINEA</topic><topic>COAGULATION SANGUINE</topic><topic>COMPOSE NITROSE</topic><topic>COMPUESTOS NITROSOS</topic><topic>endothelial function</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>ENDOTHELIUM-DERIVED RELAXING FACTOR</topic><topic>HOMOCISTEINA</topic><topic>HOMOCYSTEINE</topic><topic>Homocysteine - toxicity</topic><topic>Humans</topic><topic>MECHANICAL PROPERTIES</topic><topic>Mercaptoethanol</topic><topic>Metabolism</topic><topic>NITRIC OXIDE</topic><topic>Nitric Oxide - physiology</topic><topic>NITROSO COMPOUNDS</topic><topic>Nitroso Compounds - pharmacology</topic><topic>OXIDO NITRICO</topic><topic>OXYDE NITRIQUE</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>Platelet Adhesiveness - drug effects</topic><topic>PLATELET AGGREGATION</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>PLATELETS</topic><topic>PROPIEDADES MECANICAS</topic><topic>PROPRIETE MECANIQUE</topic><topic>PROTEINAS SANGUINEAS</topic><topic>PROTEINE SANGUINE</topic><topic>RATIOS</topic><topic>REVIEWS</topic><topic>RSNOS</topic><topic>S-Nitrosothiols</topic><topic>SISTEMA CARDIOVASCULAR</topic><topic>SYSTEME CARDIOVASCULAIRE</topic><topic>THIOL</topic><topic>THIOLS</topic><topic>THROMBOCYTE</topic><topic>TIOLES</topic><topic>TROMBOCITOS</topic><topic>VASCULAR TONE</topic><topic>VASODILATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.)</creatorcontrib><creatorcontrib>Welch, G.N</creatorcontrib><creatorcontrib>Loscalzo, J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Upchurch, G.R. Jr. (Harvard Medical School, Boston, MA.)</au><au>Welch, G.N</au><au>Loscalzo, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine, EDRF and Endothelial function</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>126</volume><issue>45</issue><spage>1290S</spage><epage>1294S</epage><pages>1290S-1294S</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Nitric oxide, a heterodiatomic molecule, serves as an endothelium-dependent vasodilator and an antithrombotic agent in the vasculature. Because of its reactivity under physiological conditions, accumulating data suggest that nitric oxide forms adducts with several classes of biologic compounds, one of which is the sulfhydryl functionality, to form thionitrites or S-nitrosothiols. In this overview, we will examine the effects of S-nitrosothiols in the vascular system as modulators of tone and inhibitors of platelet activation to understand better what role these compounds may play in physiological and pathological states. With this background, we will review the role nitric oxide (EDRF) plays in helping to ameliorate vascular injury by homocysteine</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8642473</pmid><doi>10.1093/jn/126.suppl_4.1290s</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 1996-04, Vol.126 (45), p.1290S-1294S |
| issn | 0022-3166 1541-6100 |
| language | eng |
| recordid | cdi_proquest_journals_197428013 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | ADHESION Amino acids Animals Biochemistry BLOOD CIRCULATION BLOOD COAGULATION BLOOD COAGULATION FACTORS BLOOD PLASMA BLOOD PROTEINS Blood vessels CARDIOVASCULAR SYSTEM CIRCULACION SANGUINEA CIRCULATION SANGUINE COAGULACION SANGUINEA COAGULATION SANGUINE COMPOSE NITROSE COMPUESTOS NITROSOS endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - physiology ENDOTHELIUM-DERIVED RELAXING FACTOR HOMOCISTEINA HOMOCYSTEINE Homocysteine - toxicity Humans MECHANICAL PROPERTIES Mercaptoethanol Metabolism NITRIC OXIDE Nitric Oxide - physiology NITROSO COMPOUNDS Nitroso Compounds - pharmacology OXIDO NITRICO OXYDE NITRIQUE PLASMA SANGUIN PLASMA SANGUINEO Platelet Adhesiveness - drug effects PLATELET AGGREGATION Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology PLATELETS PROPIEDADES MECANICAS PROPRIETE MECANIQUE PROTEINAS SANGUINEAS PROTEINE SANGUINE RATIOS REVIEWS RSNOS S-Nitrosothiols SISTEMA CARDIOVASCULAR SYSTEME CARDIOVASCULAIRE THIOL THIOLS THROMBOCYTE TIOLES TROMBOCITOS VASCULAR TONE VASODILATION |
| title | Homocysteine, EDRF and Endothelial function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T06%3A05%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Homocysteine,%20EDRF%20and%20Endothelial%20function&rft.jtitle=The%20Journal%20of%20nutrition&rft.au=Upchurch,%20G.R.%20Jr.%20(Harvard%20Medical%20School,%20Boston,%20MA.)&rft.date=1996-04-01&rft.volume=126&rft.issue=45&rft.spage=1290S&rft.epage=1294S&rft.pages=1290S-1294S&rft.issn=0022-3166&rft.eissn=1541-6100&rft.coden=JONUAI&rft_id=info:doi/10.1093/jn/126.suppl_4.1290s&rft_dat=%3Cproquest_cross%3E9448775%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=197428013&rft_id=info:pmid/8642473&rft_els_id=S0022316622017709&rfr_iscdi=true |