Vascular endothelial growth factor in the plasma, follicular fluid and granulosa cells of women with endometriosis submitted to in vitro fertilization - a pilot study
Vascular endothelial growth factor (VEGF), a potent angiogenic factor that is altered in endometriosis, supports the immunological mechanism involved in this disease. The aim of the present study was to assess VEGF concentration in the plasma, follicular fluid (FF) and culture medium (CM) of granulo...
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| Veröffentlicht in: | Gynecological endocrinology 2005-05, Vol.20 (5), p.284-288 |
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| creator | Oliveira, Vinícius A Abreu, Lauriane G Ferriani, Rui A Reis, Rosana M Moura, Marcos D |
| description | Vascular endothelial growth factor (VEGF), a potent angiogenic factor that is altered in endometriosis, supports the immunological mechanism involved in this disease. The aim of the present study was to assess VEGF concentration in the plasma, follicular fluid (FF) and culture medium (CM) of granulosa cells from patients with endometriosis submitted to in vitro fertilization (IVF). A case-control study was conducted on 14 patients with endometriosis and 14 women without endometriosis submitted to IVF. Peripheral blood samples were collected before and after administration of human chorionic gonadotropin (hCG), in addition to FF and CM samples. Plasma VEGF levels increased after hCG administration in women with endometriosis and in controls, but were significant only in controls. VEGF levels were lower in FF but were significantly increased in the CM of patients with endometriosis. There was no correlation between VEGF and age, response to ovarian stimulation, oocyte or embryo quality, and pregnancy result. The increase of VEGF levels after hCG in both groups demonstrated a positive effect of this hormone on VEGF. VEGF in the FF and CM presented opposite results in endometriosis, suggesting that granulosa cells may show a different behavior in vivo and in vitro. |
| doi_str_mv | 10.1080/09513590500097952 |
| format | Article |
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The aim of the present study was to assess VEGF concentration in the plasma, follicular fluid (FF) and culture medium (CM) of granulosa cells from patients with endometriosis submitted to in vitro fertilization (IVF). A case-control study was conducted on 14 patients with endometriosis and 14 women without endometriosis submitted to IVF. Peripheral blood samples were collected before and after administration of human chorionic gonadotropin (hCG), in addition to FF and CM samples. Plasma VEGF levels increased after hCG administration in women with endometriosis and in controls, but were significant only in controls. VEGF levels were lower in FF but were significantly increased in the CM of patients with endometriosis. There was no correlation between VEGF and age, response to ovarian stimulation, oocyte or embryo quality, and pregnancy result. The increase of VEGF levels after hCG in both groups demonstrated a positive effect of this hormone on VEGF. VEGF in the FF and CM presented opposite results in endometriosis, suggesting that granulosa cells may show a different behavior in vivo and in vitro.</description><identifier>ISSN: 0951-3590</identifier><identifier>EISSN: 1473-0766</identifier><identifier>DOI: 10.1080/09513590500097952</identifier><identifier>PMID: 16019375</identifier><identifier>CODEN: GYENER</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Case-Control Studies ; Endometriosis ; Endometriosis - blood ; Endometriosis - complications ; Endometriosis - metabolism ; Female ; Fertilization in Vitro ; follicular fluid ; Follicular Fluid - metabolism ; granulosa cells ; Granulosa Cells - metabolism ; Humans ; in vitro fertilization ; Infertility, Female - blood ; Infertility, Female - complications ; Infertility, Female - metabolism ; Pilot Projects ; Pregnancy ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Gynecological endocrinology, 2005-05, Vol.20 (5), p.284-288</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>Copyright CRC Press May 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-e28944e4f020b9232a2976e4f83cad2304bf28a0a00b5e93187db3ec2ddbc3533</citedby><cites>FETCH-LOGICAL-c431t-e28944e4f020b9232a2976e4f83cad2304bf28a0a00b5e93187db3ec2ddbc3533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09513590500097952$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09513590500097952$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16019375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, Vinícius A</creatorcontrib><creatorcontrib>Abreu, Lauriane G</creatorcontrib><creatorcontrib>Ferriani, Rui A</creatorcontrib><creatorcontrib>Reis, Rosana M</creatorcontrib><creatorcontrib>Moura, Marcos D</creatorcontrib><title>Vascular endothelial growth factor in the plasma, follicular fluid and granulosa cells of women with endometriosis submitted to in vitro fertilization - a pilot study</title><title>Gynecological endocrinology</title><addtitle>Gynecol Endocrinol</addtitle><description>Vascular endothelial growth factor (VEGF), a potent angiogenic factor that is altered in endometriosis, supports the immunological mechanism involved in this disease. The aim of the present study was to assess VEGF concentration in the plasma, follicular fluid (FF) and culture medium (CM) of granulosa cells from patients with endometriosis submitted to in vitro fertilization (IVF). A case-control study was conducted on 14 patients with endometriosis and 14 women without endometriosis submitted to IVF. Peripheral blood samples were collected before and after administration of human chorionic gonadotropin (hCG), in addition to FF and CM samples. Plasma VEGF levels increased after hCG administration in women with endometriosis and in controls, but were significant only in controls. VEGF levels were lower in FF but were significantly increased in the CM of patients with endometriosis. There was no correlation between VEGF and age, response to ovarian stimulation, oocyte or embryo quality, and pregnancy result. The increase of VEGF levels after hCG in both groups demonstrated a positive effect of this hormone on VEGF. VEGF in the FF and CM presented opposite results in endometriosis, suggesting that granulosa cells may show a different behavior in vivo and in vitro.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Endometriosis</subject><subject>Endometriosis - blood</subject><subject>Endometriosis - complications</subject><subject>Endometriosis - metabolism</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>follicular fluid</subject><subject>Follicular Fluid - metabolism</subject><subject>granulosa cells</subject><subject>Granulosa Cells - metabolism</subject><subject>Humans</subject><subject>in vitro fertilization</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - complications</subject><subject>Infertility, Female - metabolism</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0951-3590</issn><issn>1473-0766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcuKFDEUhoMoTjv6AG4kuHA1pSdJ3YKzkWG8wIAbdVucysXOkKq0ScqmfSCf0xTd4A1dhXC-7ycnPyGPGTxn0MMLkA0TjYQGAGQnG36HbFjdiQq6tr1LNuu8WoEz8iClWwAm6o7fJ2esBSZF12zI90-Y1OIxUjPrkLfGO_T0cwz7vKUWVQ6RupmWAd15TBNeUBu8d0fH-sVpirMuBs6LDwmpMt4nGizdh8nMdO9K0Jo9mRxdSC7RtIyTy9lomsMa_tXlGKg1MTvvvmF2YaYVRbpzPmSa8qIPD8k9iz6ZR6fznHx8ff3h6m118_7Nu6tXN5WqBcuV4b2sa1Nb4DBKLjhy2bXl3guFmguoR8t7BAQYGyMF6zs9CqO41qMSjRDn5NkxdxfDl8WkPEwurRvhbMKShrYHIVvZFfDpH-BtWOJc3jYw2dW8aVsoEDtCKoaUorHDLroJ42FgMKwNDn81WJwnp-DyS0b_NE6VFeDyCLjZhjjhPkSvh4wHH6ItLSiXBvG__Je_6VuDPm8VRvPLBv-0fwDdaL6t</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Oliveira, Vinícius A</creator><creator>Abreu, Lauriane G</creator><creator>Ferriani, Rui A</creator><creator>Reis, Rosana M</creator><creator>Moura, Marcos D</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>Vascular endothelial growth factor in the plasma, follicular fluid and granulosa cells of women with endometriosis submitted to in vitro fertilization - a pilot study</title><author>Oliveira, Vinícius A ; Abreu, Lauriane G ; Ferriani, Rui A ; Reis, Rosana M ; Moura, Marcos D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-e28944e4f020b9232a2976e4f83cad2304bf28a0a00b5e93187db3ec2ddbc3533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Endometriosis</topic><topic>Endometriosis - blood</topic><topic>Endometriosis - complications</topic><topic>Endometriosis - metabolism</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>follicular fluid</topic><topic>Follicular Fluid - metabolism</topic><topic>granulosa cells</topic><topic>Granulosa Cells - metabolism</topic><topic>Humans</topic><topic>in vitro fertilization</topic><topic>Infertility, Female - blood</topic><topic>Infertility, Female - complications</topic><topic>Infertility, Female - metabolism</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Vinícius A</creatorcontrib><creatorcontrib>Abreu, Lauriane G</creatorcontrib><creatorcontrib>Ferriani, Rui A</creatorcontrib><creatorcontrib>Reis, Rosana M</creatorcontrib><creatorcontrib>Moura, Marcos D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecological endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Vinícius A</au><au>Abreu, Lauriane G</au><au>Ferriani, Rui A</au><au>Reis, Rosana M</au><au>Moura, Marcos D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular endothelial growth factor in the plasma, follicular fluid and granulosa cells of women with endometriosis submitted to in vitro fertilization - a pilot study</atitle><jtitle>Gynecological endocrinology</jtitle><addtitle>Gynecol Endocrinol</addtitle><date>2005-05</date><risdate>2005</risdate><volume>20</volume><issue>5</issue><spage>284</spage><epage>288</epage><pages>284-288</pages><issn>0951-3590</issn><eissn>1473-0766</eissn><coden>GYENER</coden><abstract>Vascular endothelial growth factor (VEGF), a potent angiogenic factor that is altered in endometriosis, supports the immunological mechanism involved in this disease. The aim of the present study was to assess VEGF concentration in the plasma, follicular fluid (FF) and culture medium (CM) of granulosa cells from patients with endometriosis submitted to in vitro fertilization (IVF). A case-control study was conducted on 14 patients with endometriosis and 14 women without endometriosis submitted to IVF. Peripheral blood samples were collected before and after administration of human chorionic gonadotropin (hCG), in addition to FF and CM samples. Plasma VEGF levels increased after hCG administration in women with endometriosis and in controls, but were significant only in controls. VEGF levels were lower in FF but were significantly increased in the CM of patients with endometriosis. There was no correlation between VEGF and age, response to ovarian stimulation, oocyte or embryo quality, and pregnancy result. The increase of VEGF levels after hCG in both groups demonstrated a positive effect of this hormone on VEGF. VEGF in the FF and CM presented opposite results in endometriosis, suggesting that granulosa cells may show a different behavior in vivo and in vitro.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16019375</pmid><doi>10.1080/09513590500097952</doi><tpages>5</tpages></addata></record> |
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| ispartof | Gynecological endocrinology, 2005-05, Vol.20 (5), p.284-288 |
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| source | Taylor & Francis; MEDLINE |
| subjects | Adult Case-Control Studies Endometriosis Endometriosis - blood Endometriosis - complications Endometriosis - metabolism Female Fertilization in Vitro follicular fluid Follicular Fluid - metabolism granulosa cells Granulosa Cells - metabolism Humans in vitro fertilization Infertility, Female - blood Infertility, Female - complications Infertility, Female - metabolism Pilot Projects Pregnancy Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - metabolism |
| title | Vascular endothelial growth factor in the plasma, follicular fluid and granulosa cells of women with endometriosis submitted to in vitro fertilization - a pilot study |
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