A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting
Summary We conducted a randomised double‐blinded study of 960 women undergoing day‐case surgery to determine whether combination anti‐emetic therapy of granisetron and cyclizine was more effective at decreasing the incidence of postoperative nausea and vomiting than these agents used alone. The wome...
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| Veröffentlicht in: | Anaesthesia 2006-11, Vol.61 (11), p.1053-1057 |
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| creator | Johns, R. A. Hanousek, J. Montgomery, J. E. |
| description | Summary
We conducted a randomised double‐blinded study of 960 women undergoing day‐case surgery to determine whether combination anti‐emetic therapy of granisetron and cyclizine was more effective at decreasing the incidence of postoperative nausea and vomiting than these agents used alone. The women were randomly allocated to three groups to receive intravenous granisetron 1 mg, cyclizine 50 mg or both before induction of general anaesthesia. The incidence of postoperative nausea and vomiting was 77/322 (24%) in the granisetron group, 73/316 (23%) in the cyclizine group and 53/322 (17%) in those women given both drugs (p = 0.04). There was no difference in the requirement for rescue anti‐emetic drugs. There were no differences in the anaesthetic techniques used in the three groups. We conclude that the risk of postoperative nausea and vomiting is less with cyclizine and granisetron given together than with either given alone. |
| doi_str_mv | 10.1111/j.1365-2044.2006.04794.x |
| format | Article |
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We conducted a randomised double‐blinded study of 960 women undergoing day‐case surgery to determine whether combination anti‐emetic therapy of granisetron and cyclizine was more effective at decreasing the incidence of postoperative nausea and vomiting than these agents used alone. The women were randomly allocated to three groups to receive intravenous granisetron 1 mg, cyclizine 50 mg or both before induction of general anaesthesia. The incidence of postoperative nausea and vomiting was 77/322 (24%) in the granisetron group, 73/316 (23%) in the cyclizine group and 53/322 (17%) in those women given both drugs (p = 0.04). There was no difference in the requirement for rescue anti‐emetic drugs. There were no differences in the anaesthetic techniques used in the three groups. We conclude that the risk of postoperative nausea and vomiting is less with cyclizine and granisetron given together than with either given alone.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2006.04794.x</identifier><identifier>PMID: 17042842</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Ambulatory Surgical Procedures ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antiemetics - adverse effects ; Antiemetics - therapeutic use ; Biological and medical sciences ; Clinical trials ; Cyclizine - adverse effects ; Cyclizine - therapeutic use ; Double-Blind Method ; Drug therapy ; Drug Therapy, Combination ; Female ; Granisetron - adverse effects ; Granisetron - therapeutic use ; Humans ; Medical sciences ; Nausea ; Postoperative Nausea and Vomiting - prevention & control ; Postoperative period ; Prospective Studies ; Risk Factors ; Vomiting</subject><ispartof>Anaesthesia, 2006-11, Vol.61 (11), p.1053-1057</ispartof><rights>2006 INIST-CNRS</rights><rights>2006 The Authors Journal compilation 2006 The Association of Anaesthetists of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4254-d8a9ff82d679d6f3eb7e27abc29456d311fce25808a46a8c21f1ef1f6264e3e33</citedby><cites>FETCH-LOGICAL-c4254-d8a9ff82d679d6f3eb7e27abc29456d311fce25808a46a8c21f1ef1f6264e3e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.2006.04794.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.2006.04794.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18204039$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17042842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johns, R. A.</creatorcontrib><creatorcontrib>Hanousek, J.</creatorcontrib><creatorcontrib>Montgomery, J. E.</creatorcontrib><title>A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
We conducted a randomised double‐blinded study of 960 women undergoing day‐case surgery to determine whether combination anti‐emetic therapy of granisetron and cyclizine was more effective at decreasing the incidence of postoperative nausea and vomiting than these agents used alone. The women were randomly allocated to three groups to receive intravenous granisetron 1 mg, cyclizine 50 mg or both before induction of general anaesthesia. The incidence of postoperative nausea and vomiting was 77/322 (24%) in the granisetron group, 73/316 (23%) in the cyclizine group and 53/322 (17%) in those women given both drugs (p = 0.04). There was no difference in the requirement for rescue anti‐emetic drugs. There were no differences in the anaesthetic techniques used in the three groups. We conclude that the risk of postoperative nausea and vomiting is less with cyclizine and granisetron given together than with either given alone.</description><subject>Adult</subject><subject>Ambulatory Surgical Procedures</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antiemetics - adverse effects</subject><subject>Antiemetics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clinical trials</subject><subject>Cyclizine - adverse effects</subject><subject>Cyclizine - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Granisetron - adverse effects</subject><subject>Granisetron - therapeutic use</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nausea</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Postoperative period</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Vomiting</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9v2yAYh9HUac26fYUKTerRHv-C8WVSVKXbpGq7bGdE8EtH5IALTtr00w8n1nodFxDv8_uBHoQwJTUt6_O2plwuK0aEqBkhsiaiaUX9_AYt_g0u0IIQwismSHuJ3ue8JYQyRdU7dEkbIpgSbIFeVtjG3WCSzzHg6LA92t6_-ADYhA4_JBN8hjGVoenjfOvDFNr4YEZfBi4mPP4BPCQ4QDhdlaIh5jEOkApzABzMPoM5pQ9x50cfHj6gt870GT7O-xX6fbf-dfutuv_59fvt6r6ygi1F1SnTOqdYJ5u2k47DpgHWmI1lrVjKjlPqLLClIsoIaZRl1FFw1EkmBXDg_Ap9OvcOKT7uIY96G_cplCc1bRsuG8VJgdQZsinmnMDpIfmdSUdNiZ6c662e1OpJrZ6c65Nz_Vyi13P_frOD7jU4Sy7AzQyYbE3vilPr8yunSifhbeG-nLkn38Pxvz-gVz9W6-nI_wK63p75</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Johns, R. A.</creator><creator>Hanousek, J.</creator><creator>Montgomery, J. E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>200611</creationdate><title>A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting</title><author>Johns, R. A. ; Hanousek, J. ; Montgomery, J. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4254-d8a9ff82d679d6f3eb7e27abc29456d311fce25808a46a8c21f1ef1f6264e3e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Ambulatory Surgical Procedures</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antiemetics - adverse effects</topic><topic>Antiemetics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clinical trials</topic><topic>Cyclizine - adverse effects</topic><topic>Cyclizine - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug therapy</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Granisetron - adverse effects</topic><topic>Granisetron - therapeutic use</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nausea</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Postoperative period</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johns, R. A.</creatorcontrib><creatorcontrib>Hanousek, J.</creatorcontrib><creatorcontrib>Montgomery, J. E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johns, R. A.</au><au>Hanousek, J.</au><au>Montgomery, J. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2006-11</date><risdate>2006</risdate><volume>61</volume><issue>11</issue><spage>1053</spage><epage>1057</epage><pages>1053-1057</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
We conducted a randomised double‐blinded study of 960 women undergoing day‐case surgery to determine whether combination anti‐emetic therapy of granisetron and cyclizine was more effective at decreasing the incidence of postoperative nausea and vomiting than these agents used alone. The women were randomly allocated to three groups to receive intravenous granisetron 1 mg, cyclizine 50 mg or both before induction of general anaesthesia. The incidence of postoperative nausea and vomiting was 77/322 (24%) in the granisetron group, 73/316 (23%) in the cyclizine group and 53/322 (17%) in those women given both drugs (p = 0.04). There was no difference in the requirement for rescue anti‐emetic drugs. There were no differences in the anaesthetic techniques used in the three groups. We conclude that the risk of postoperative nausea and vomiting is less with cyclizine and granisetron given together than with either given alone.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17042842</pmid><doi>10.1111/j.1365-2044.2006.04794.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adult Ambulatory Surgical Procedures Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antiemetics - adverse effects Antiemetics - therapeutic use Biological and medical sciences Clinical trials Cyclizine - adverse effects Cyclizine - therapeutic use Double-Blind Method Drug therapy Drug Therapy, Combination Female Granisetron - adverse effects Granisetron - therapeutic use Humans Medical sciences Nausea Postoperative Nausea and Vomiting - prevention & control Postoperative period Prospective Studies Risk Factors Vomiting |
| title | A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting |
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