Pharmacotherapy for Seizures in Neonates with Hypoxic Ischemic Encephalopathy

Seizures are common in neonates with moderate and severe hypoxic ischemic encephalopathy (HIE) and are associated with worse outcomes, independent of HIE severity. In contrast to adults and older children, no new drugs have been licensed for treatment of neonatal seizures over the last 50 years, bec...

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Veröffentlicht in:	Paediatric drugs 2017-12, Vol.19 (6), p.553-567
Hauptverfasser:	Yozawitz, Elissa, Stacey, Arthur, Pressler, Ronit M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - administration & dosage Anticonvulsants - pharmacokinetics Anticonvulsants - therapeutic use Brain damage Children & youth Clinical trials Complications and side effects Convulsions & seizures Cooling Demographic aspects Diagnosis Diseases Drug dosages Drug therapy Encephalopathy Epilepsy Feasibility studies Humans Hypoxia Hypoxia-Ischemia, Brain - drug therapy Hypoxia-Ischemia, Brain - physiopathology Infant, Newborn Infants (Newborn) Internal Medicine Ischemia Licenses Medicine Medicine & Public Health Metabolism Newborn babies Off-Label Use Pediatrics Pharmacotherapy Review Article Risk factors Seizures (Medicine) Seizures - drug therapy Systematic review
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