One‐pot synthesis of fluorescent nitrogen‐doped carbon dots with good biocompatibility for cell labeling
Here we report an easy and economical hydrothermal carbonization approach to synthesize the fluorescent nitrogen‐doped carbon dots (N‐CDs) that was developed using citric acid and triethanolamine as the precursors. The synthesis conditions were optimized to obtain the N‐CDs with superior fluorescenc...
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| Veröffentlicht in: | Luminescence (Chichester, England) England), 2017-12, Vol.32 (8), p.1488-1493 |
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| container_title | Luminescence (Chichester, England) |
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| creator | Zhang, Zhengwei Yan, Kun Yang, Qiulian Liu, Yanhua Yan, Zhengyu Chen, Jianqiu |
| description | Here we report an easy and economical hydrothermal carbonization approach to synthesize the fluorescent nitrogen‐doped carbon dots (N‐CDs) that was developed using citric acid and triethanolamine as the precursors. The synthesis conditions were optimized to obtain the N‐CDs with superior fluorescence performances. The as‐prepared N‐CDs are monodispersed sphere nanoparticles with good water solubility, and exhibited strong fluorescence, favourable photostability and excitation wavelength‐dependent behavior. Furthermore, the in vitro cytotoxicity and cellular labeling of N‐CDs were investigated using the rat glomerular mesangial cells. The results showed the N‐CDs have more inconspicuous cytotoxicity and better biosafety in comparison with ZnSe quantum dots, although both targeted the cells successfully. Considering their admirable photostability, low toxicity and good compatibility, the as‐obtained N‐CDs could have potential applications in biosensors, cellular imaging, and other fields. |
| doi_str_mv | 10.1002/bio.3349 |
| format | Article |
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The synthesis conditions were optimized to obtain the N‐CDs with superior fluorescence performances. The as‐prepared N‐CDs are monodispersed sphere nanoparticles with good water solubility, and exhibited strong fluorescence, favourable photostability and excitation wavelength‐dependent behavior. Furthermore, the in vitro cytotoxicity and cellular labeling of N‐CDs were investigated using the rat glomerular mesangial cells. The results showed the N‐CDs have more inconspicuous cytotoxicity and better biosafety in comparison with ZnSe quantum dots, although both targeted the cells successfully. Considering their admirable photostability, low toxicity and good compatibility, the as‐obtained N‐CDs could have potential applications in biosensors, cellular imaging, and other fields.</description><identifier>ISSN: 1522-7235</identifier><identifier>EISSN: 1522-7243</identifier><identifier>DOI: 10.1002/bio.3349</identifier><identifier>PMID: 28590024</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Biocompatibility ; Biosafety ; Biosensors ; Carbon dots ; Carbonization ; cellular imaging ; characterization ; Citric acid ; Cytotoxicity ; Fluorescence ; Imaging techniques ; Labeling ; Mesangial cells ; Nanoparticles ; Nitrogen ; nitrogen‐doped carbon dots ; Quantum dots ; Synthesis ; Toxicity ; Triethanolamine ; Wavelength</subject><ispartof>Luminescence (Chichester, England), 2017-12, Vol.32 (8), p.1488-1493</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3499-7a6a058faa15ce1fca38e82af9933e02a8111a0785f863670b3a1b3ebd091b463</citedby><cites>FETCH-LOGICAL-c3499-7a6a058faa15ce1fca38e82af9933e02a8111a0785f863670b3a1b3ebd091b463</cites><orcidid>0000-0002-6169-497X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbio.3349$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbio.3349$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28590024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhengwei</creatorcontrib><creatorcontrib>Yan, Kun</creatorcontrib><creatorcontrib>Yang, Qiulian</creatorcontrib><creatorcontrib>Liu, Yanhua</creatorcontrib><creatorcontrib>Yan, Zhengyu</creatorcontrib><creatorcontrib>Chen, Jianqiu</creatorcontrib><title>One‐pot synthesis of fluorescent nitrogen‐doped carbon dots with good biocompatibility for cell labeling</title><title>Luminescence (Chichester, England)</title><addtitle>Luminescence</addtitle><description>Here we report an easy and economical hydrothermal carbonization approach to synthesize the fluorescent nitrogen‐doped carbon dots (N‐CDs) that was developed using citric acid and triethanolamine as the precursors. 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Considering their admirable photostability, low toxicity and good compatibility, the as‐obtained N‐CDs could have potential applications in biosensors, cellular imaging, and other fields.</description><subject>Biocompatibility</subject><subject>Biosafety</subject><subject>Biosensors</subject><subject>Carbon dots</subject><subject>Carbonization</subject><subject>cellular imaging</subject><subject>characterization</subject><subject>Citric acid</subject><subject>Cytotoxicity</subject><subject>Fluorescence</subject><subject>Imaging techniques</subject><subject>Labeling</subject><subject>Mesangial cells</subject><subject>Nanoparticles</subject><subject>Nitrogen</subject><subject>nitrogen‐doped carbon dots</subject><subject>Quantum dots</subject><subject>Synthesis</subject><subject>Toxicity</subject><subject>Triethanolamine</subject><subject>Wavelength</subject><issn>1522-7235</issn><issn>1522-7243</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kDtOAzEQhi0EghCQOAGyREOz4Me-XALiJUVKA_XK3h0HI8debEdROo7AGTkJGxLSUc0U33wz8yN0RskVJYRdK-OvOM_FHhrRgrGsYjnf3_W8OELHMb4TQsqyFIfoiNWFGObyEbJTB9-fX71POK5ceoNoIvYaa7vwAWILLmFnUvAzcAPX-R463MqgvMOdTxEvTXrDM-87PBzR-nkvk1HGmrTC2gfcgrXYSgXWuNkJOtDSRjjd1jF6fbh_uXvKJtPH57ubSdYOP4iskqUkRa2lpEULVLeS11AzqYXgHAiTNaVUkqoudF3ysiKKS6o4qI4IqvKSj9HFxtsH_7GAmJp3vwhuWNlQUTGWC1asqcsN1QYfYwDd9MHMZVg1lDTrWJvho2Yd64Ceb4ULNYduB_7lOADZBlgaC6t_Rc3t8_RX-APOA4Qp</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Zhang, Zhengwei</creator><creator>Yan, Kun</creator><creator>Yang, Qiulian</creator><creator>Liu, Yanhua</creator><creator>Yan, Zhengyu</creator><creator>Chen, Jianqiu</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H95</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L.G</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-6169-497X</orcidid></search><sort><creationdate>201712</creationdate><title>One‐pot synthesis of fluorescent nitrogen‐doped carbon dots with good biocompatibility for cell labeling</title><author>Zhang, Zhengwei ; 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The synthesis conditions were optimized to obtain the N‐CDs with superior fluorescence performances. The as‐prepared N‐CDs are monodispersed sphere nanoparticles with good water solubility, and exhibited strong fluorescence, favourable photostability and excitation wavelength‐dependent behavior. Furthermore, the in vitro cytotoxicity and cellular labeling of N‐CDs were investigated using the rat glomerular mesangial cells. The results showed the N‐CDs have more inconspicuous cytotoxicity and better biosafety in comparison with ZnSe quantum dots, although both targeted the cells successfully. 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| subjects | Biocompatibility Biosafety Biosensors Carbon dots Carbonization cellular imaging characterization Citric acid Cytotoxicity Fluorescence Imaging techniques Labeling Mesangial cells Nanoparticles Nitrogen nitrogen‐doped carbon dots Quantum dots Synthesis Toxicity Triethanolamine Wavelength |
| title | One‐pot synthesis of fluorescent nitrogen‐doped carbon dots with good biocompatibility for cell labeling |
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