Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies

BACKGROUND Pracinostat is a potent histone deacetylase inhibitor with antitumor activity in both solid tumor and acute myeloid leukemia (AML) cell lines. Pracinostat is reported to have modest clinical activity in patients with advanced solid tumors. Given the higher preclinical sensitivity of hemat...

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Veröffentlicht in:	Cancer 2017-12, Vol.123 (24), p.4851-4859
Hauptverfasser:	Abaza, Yasmin M., Kadia, Tapan M., Jabbour, Elias J., Konopleva, Marina Y., Borthakur, Gautam, Ferrajoli, Alessandra, Estrov, Zeev, Wierda, William G., Alfonso, Ana, Chong, Toh Han, Chuah, Charles, Koh, Liang‐Piu, Goh, Boon‐Cher, Chang, Julie E., Durkes, Daniel E., Foudray, Maria Cielo, Kantarjian, Hagop M., Dong, Xiao Qin, Garcia‐Manero, Guillermo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acute myeloid leukemia Adult Age Factors Aged Aged, 80 and over Anticancer properties Antitumor activity Azacitidine - administration & dosage Azacitidine - adverse effects Benzimidazoles - administration & dosage Benzimidazoles - adverse effects Blood cancer Cancer Chromatin Disease-Free Survival Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination epigenetic Female Follow-Up Studies Hematologic Neoplasms - drug therapy Hematologic Neoplasms - mortality Hematologic Neoplasms - pathology Hematology histone Histone deacetylase Humans Kaplan-Meier Estimate Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Maximum Tolerated Dose methylation Middle Aged Myelodysplastic syndrome Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - mortality Myelodysplastic Syndromes - pathology Myeloid leukemia Neoplasm Invasiveness - pathology Neoplasm Staging Oncology Patient Safety Patients Pharmacodynamics Pharmacokinetics Pharmacology pracinostat Remission Risk Assessment Safety Sex Factors Solid tumors Survival Analysis Toxicity Treatment Outcome Tumor cell lines Tumors
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