eIF3a: A new anticancer drug target in the eIF family

eIF3a is the largest subunit of eIF3, which is a key player in all steps of translation initiation. During the past years, eIF3a is recognized as a proto-oncogene, which is an important discovery in this field. It is widely reported to be correlated with cancer occurrence, metastasis, prognosis, and...

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Veröffentlicht in:	Cancer letters 2018-01, Vol.412, p.81-87
Hauptverfasser:	Yin, Ji-Ye, Zhang, Jian-Ting, Zhang, Wei, Zhou, Hong-Hao, Liu, Zhao-Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer Antineoplastic Agents - pharmacology Cancer Carcinogenesis Cell Cycle Chemotherapy Cytoplasm DNA - biosynthesis DNA Repair Drug target Drug therapy eIF3a Eukaryotic Initiation Factor-3 - analysis Eukaryotic Initiation Factor-3 - antagonists & inhibitors Eukaryotic Initiation Factor-3 - chemistry Eukaryotic Initiation Factor-3 - physiology Gene expression Humans Hypoxia Mammals Metastases Mutation Pancreatic cancer Physiology Proteins Pulmonary fibrosis Rodents Translation initiation Translation regulation
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