Distinct PKA regulatory subunits mediate PGE^sub 2^ inhibition of TGF?-1-stimulated collagen I translation and myofibroblast differentiation

Prostaglandin E2 (PGE2), via cAMP signaling, inhibits a variety of fibroblast functions relevant to fibrogenesis. Among these are their translation of collagen I protein and their differentiation to myofibroblasts. PKA is central to these actions, with cAMP binding to regulatory (R) subunits leading...

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