Lysosome‐Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs

Cancer cells produce elevated levels of reactive oxygen species, which has been used to design cancer specific prodrugs. Their activation relies on at least a bimolecular process, in which a prodrug reacts with ROS. However, at low micromolar concentrations of the prodrugs and ROS, the activation is...

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Veröffentlicht in:	Angewandte Chemie International Edition 2017-12, Vol.56 (49), p.15545-15549
Hauptverfasser:	Daum, Steffen, Reshetnikov, M. S. Viktor, Sisa, Miroslav, Dumych, Tetyana, Lootsik, Maxim D., Bilyy, Rostyslav, Bila, Evgenia, Janko, Christina, Alexiou, Christoph, Herrmann, Martin, Sellner, Leopold, Mokhir, Andriy
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation aminoferrocene Amplifiers Animal models Animals Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Cancer Cell Line Cell Proliferation - drug effects Chemical compounds Cytoplasm Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Drugs Humans Lysosomes Lysosomes - drug effects Lysosomes - metabolism Mice Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Prodrugs Prodrugs - chemistry Prodrugs - pharmacology Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Structure-Activity Relationship Tumor cell lines
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