Role of WNT 10A in failure of tooth development in humans and zebrafish

BackgroundOligodontia is a severe form of tooth agenesis characterized by the absence of six or more permanent teeth. Oligodontia has complex etiology and variations in numerous genes have been suggested as causal for the condition.MethodsWe applied whole‐exome sequencing (WES) to identify the cause...

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Veröffentlicht in:	Molecular genetics & genomic medicine 2017-11, Vol.5 (6), p.730-741
Hauptverfasser:	Yuan, Qiuping, Zhao, Min, Tandon, Bhavna, Maili, Lorena, Liu, Xiaoming, Zhang, Anqi, Baugh, Evan H., Tran, Tam, Silva, Renato M., Hecht, Jacqueline T., Swindell, Eric C., Wagner, Daniel S., Letra, Ariadne
Format:	Artikel
Sprache:	eng
Schlagworte:	Danio rerio Embryos Etiology Functional analysis Gene expression Genes Hominids Missense mutation Protein folding Proteins Teeth Zebrafish
Online-Zugang:	Volltext
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