The Neuroprotective Role of MiR‐124‐3p in a 6‐Hydroxydopamine‐Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5

ABSTRACT Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by a progressive loss of dopaminergic neurons in the midbrain. Several pathogenetic factors have been involved in the onset and progression of PD, including inflammation, oxidative stress, unf...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-01, Vol.119 (1), p.269-277
Hauptverfasser:	Dong, Rui‐Fang, Zhang, Bing, Tai, Li‐Wen, Liu, Hong‐Mei, Shi, Fang‐Kun, Liu, Ning‐Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine 6‐OHDA Animals Annexin A5 - biosynthesis Annexin A5 - genetics ANXA5 Apoptosis Caspase Caspase-3 Chromosome 3 Dopamine receptors Gene expression Gene Expression Regulation - drug effects Mesencephalon Metabolic pathways MicroRNAs - biosynthesis MicroRNAs - genetics miR‐124‐3p Models, Biological Movement disorders Neurodegenerative diseases Neuroprotection Neurotoxicity Oxidative stress Oxidopamine - adverse effects Oxidopamine - pharmacology Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - genetics Parkinson Disease, Secondary - metabolism Parkinson Disease, Secondary - pathology PARKINSON'S DISEASE PC12 Cells Pheochromocytoma cells Post-transcription Protein folding Rats
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