Gemcitabine and pemetrexed administered in rapid sequence as front-line chemotherapy for advanced non-small-cell lung cancer: a phase II clinical trial

Previous studies of the gemcitabine–pemetrexed combination in patients with late-stage non-small-cell lung cancer (NSCLC) utilized a 90-min delay between gemcitabine and pemetrexed administration. This phase II study evaluated activity when these agents were administered in rapid succession. Chemona...

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Veröffentlicht in:	Annals of oncology 2009-05, Vol.20 (5), p.850-856
Hauptverfasser:	West, H.L., Wakelee, H.A., Perry, M.C., Belt, R.J., Chen, R., Obasaju, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - administration & dosage Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Disease-Free Survival Drug Administration Schedule Female Folic Acid Antagonists - administration & dosage gemcitabine Glutamates - administration & dosage Guanine - administration & dosage Guanine - analogs & derivatives Humans immediate administration Kaplan-Meier Estimate Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical sciences Middle Aged Neoplasm Staging NSCLC Pemetrexed Pharmacology. Drug treatments Pneumology rapid-sequence administration Time Factors Treatment Outcome Tumors of the respiratory system and mediastinum United States - epidemiology
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