History of treated hypertension and diabetes mellitus and risk of renal cell cancer
Background: An increased risk of renal cell cancer (RCC) has been reported in subjects with hypertension. Whether this association may vary according to sex, smoking, obesity, or RCC clinical presentation is unclear. Results on the link between diabetes mellitus and RCC are inconclusive. Patients an...
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| Veröffentlicht in: | Annals of oncology 2007-03, Vol.18 (3), p.596-600 |
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| creator | Zucchetto, A Dal Maso, L Tavani, A Montella, M Ramazzotti, V Talamini, R Canzonieri, V Garbeglio, A Negri, E Franceschi, S La Vecchia, C |
| description | Background: An increased risk of renal cell cancer (RCC) has been reported in subjects with hypertension. Whether this association may vary according to sex, smoking, obesity, or RCC clinical presentation is unclear. Results on the link between diabetes mellitus and RCC are inconclusive. Patients and methods: We conducted an Italian multicenter case–control study, including 767 (494 men, 273 women) incident cases of RCC, under 80 years of age, and 1534 hospital controls, frequency-matched to cases. Multiple logistic regression models, conditioned to center, sex, and age, and adjusted for period of interview, education, smoking, and body mass were used to estimate odds ratios (OR). Results: Compared with subjects never treated, patients with a history of treated hypertension [OR = 1.7, 95% confidence interval (CI) 1.4–2.1] reported an excess risk of RCC. This pattern was confirmed in different strata of sex, education, smoking habits, body mass, tumor histological type, stage, or grade. The attributable risk of RCC for treated hypertension in this population was 16%. A slight, nonsignificant increased risk was found for history of diabetes mellitus (OR = 1.3, 95% CI 0.9–1.7). Conclusion: A possible causal role of hypertension in renal cell carcinogenesis is supported by the consistency of the direct association. |
| doi_str_mv | 10.1093/annonc/mdl438 |
| format | Article |
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Whether this association may vary according to sex, smoking, obesity, or RCC clinical presentation is unclear. Results on the link between diabetes mellitus and RCC are inconclusive. Patients and methods: We conducted an Italian multicenter case–control study, including 767 (494 men, 273 women) incident cases of RCC, under 80 years of age, and 1534 hospital controls, frequency-matched to cases. Multiple logistic regression models, conditioned to center, sex, and age, and adjusted for period of interview, education, smoking, and body mass were used to estimate odds ratios (OR). Results: Compared with subjects never treated, patients with a history of treated hypertension [OR = 1.7, 95% confidence interval (CI) 1.4–2.1] reported an excess risk of RCC. This pattern was confirmed in different strata of sex, education, smoking habits, body mass, tumor histological type, stage, or grade. The attributable risk of RCC for treated hypertension in this population was 16%. A slight, nonsignificant increased risk was found for history of diabetes mellitus (OR = 1.3, 95% CI 0.9–1.7). Conclusion: A possible causal role of hypertension in renal cell carcinogenesis is supported by the consistency of the direct association.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdl438</identifier><identifier>PMID: 17158772</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Antihypertensive Agents - therapeutic use ; Antineoplastic agents ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Carcinoma, Renal Cell - epidemiology ; Carcinoma, Renal Cell - etiology ; Cardiology. Vascular system ; Case-Control Studies ; Diabetes Complications - epidemiology ; Diabetes Complications - etiology ; diabetes mellitus ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Humans ; hypertension ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - epidemiology ; Hypoglycemic Agents - therapeutic use ; Incidence ; Italy - epidemiology ; Kidney Neoplasms - epidemiology ; Kidney Neoplasms - etiology ; Kidneys ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Odds Ratio ; Pharmacology. Drug treatments ; renal cell cancer ; risk ; Risk Assessment ; Risk Factors ; Tumors of the urinary system</subject><ispartof>Annals of oncology, 2007-03, Vol.18 (3), p.596-600</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright Springer Science & Business Media Mar 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-8d8ea506fcbe02b08a5a99763dec6a0f7862ab3c0555ee62483c9c38c1ba3f643</citedby><cites>FETCH-LOGICAL-c425t-8d8ea506fcbe02b08a5a99763dec6a0f7862ab3c0555ee62483c9c38c1ba3f643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18604034$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17158772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zucchetto, A</creatorcontrib><creatorcontrib>Dal Maso, L</creatorcontrib><creatorcontrib>Tavani, A</creatorcontrib><creatorcontrib>Montella, M</creatorcontrib><creatorcontrib>Ramazzotti, V</creatorcontrib><creatorcontrib>Talamini, R</creatorcontrib><creatorcontrib>Canzonieri, V</creatorcontrib><creatorcontrib>Garbeglio, A</creatorcontrib><creatorcontrib>Negri, E</creatorcontrib><creatorcontrib>Franceschi, S</creatorcontrib><creatorcontrib>La Vecchia, C</creatorcontrib><title>History of treated hypertension and diabetes mellitus and risk of renal cell cancer</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Background: An increased risk of renal cell cancer (RCC) has been reported in subjects with hypertension. Whether this association may vary according to sex, smoking, obesity, or RCC clinical presentation is unclear. Results on the link between diabetes mellitus and RCC are inconclusive. Patients and methods: We conducted an Italian multicenter case–control study, including 767 (494 men, 273 women) incident cases of RCC, under 80 years of age, and 1534 hospital controls, frequency-matched to cases. Multiple logistic regression models, conditioned to center, sex, and age, and adjusted for period of interview, education, smoking, and body mass were used to estimate odds ratios (OR). Results: Compared with subjects never treated, patients with a history of treated hypertension [OR = 1.7, 95% confidence interval (CI) 1.4–2.1] reported an excess risk of RCC. This pattern was confirmed in different strata of sex, education, smoking habits, body mass, tumor histological type, stage, or grade. The attributable risk of RCC for treated hypertension in this population was 16%. A slight, nonsignificant increased risk was found for history of diabetes mellitus (OR = 1.3, 95% CI 0.9–1.7). Conclusion: A possible causal role of hypertension in renal cell carcinogenesis is supported by the consistency of the direct association.</description><subject>Adult</subject><subject>Aged</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antineoplastic agents</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Carcinoma, Renal Cell - epidemiology</subject><subject>Carcinoma, Renal Cell - etiology</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Diabetes Complications - epidemiology</subject><subject>Diabetes Complications - etiology</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - epidemiology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Incidence</subject><subject>Italy - epidemiology</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidney Neoplasms - etiology</subject><subject>Kidneys</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Odds Ratio</subject><subject>Pharmacology. Drug treatments</subject><subject>renal cell cancer</subject><subject>risk</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Tumors of the urinary system</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AQgBdRtD6OXiUIHqO72fdRirZCUUEF8bJMNhNMmyZ1NwH774222NPAzDevj5BzRq8ZtfwGmqZt_M2yqAU3e2TEpLKpoYLtkxG1GU-15OKIHMc4p5Qqm9lDcsQ0k0brbEReplXs2rBO2jLpAkKHRfK5XmHosIlV2yTQFElRQY4dxmSJdV11ffzLhiouftsCNlAnfiglHhqP4ZQclFBHPNvGE_J2f_c6nqazp8nD-HaWepHJLjWFQZBUlT5HmuXUgARrteIFegW01EZlkHNPpZSIKhOGe-u58SwHXirBT8jlZu4qtF89xs7N2z4Mx0THrFJCaqkGKN1APrQxBizdKlRLCGvHqPs16DYG3cbgwF9sh_b5EosdvVU2AFdbAKKHugzDz1XccUZRQbnYLR4E4_d_HcLCKc21dNP3D8cfZ-MJE9w98x9HzYq0</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Zucchetto, A</creator><creator>Dal Maso, L</creator><creator>Tavani, A</creator><creator>Montella, M</creator><creator>Ramazzotti, V</creator><creator>Talamini, R</creator><creator>Canzonieri, V</creator><creator>Garbeglio, A</creator><creator>Negri, E</creator><creator>Franceschi, S</creator><creator>La Vecchia, C</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20070301</creationdate><title>History of treated hypertension and diabetes mellitus and risk of renal cell cancer</title><author>Zucchetto, A ; Dal Maso, L ; Tavani, A ; Montella, M ; Ramazzotti, V ; Talamini, R ; Canzonieri, V ; Garbeglio, A ; Negri, E ; Franceschi, S ; La Vecchia, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-8d8ea506fcbe02b08a5a99763dec6a0f7862ab3c0555ee62483c9c38c1ba3f643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antineoplastic agents</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Carcinoma, Renal Cell - epidemiology</topic><topic>Carcinoma, Renal Cell - etiology</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Diabetes Complications - epidemiology</topic><topic>Diabetes Complications - etiology</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - epidemiology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Incidence</topic><topic>Italy - epidemiology</topic><topic>Kidney Neoplasms - epidemiology</topic><topic>Kidney Neoplasms - etiology</topic><topic>Kidneys</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Odds Ratio</topic><topic>Pharmacology. Drug treatments</topic><topic>renal cell cancer</topic><topic>risk</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zucchetto, A</creatorcontrib><creatorcontrib>Dal Maso, L</creatorcontrib><creatorcontrib>Tavani, A</creatorcontrib><creatorcontrib>Montella, M</creatorcontrib><creatorcontrib>Ramazzotti, V</creatorcontrib><creatorcontrib>Talamini, R</creatorcontrib><creatorcontrib>Canzonieri, V</creatorcontrib><creatorcontrib>Garbeglio, A</creatorcontrib><creatorcontrib>Negri, E</creatorcontrib><creatorcontrib>Franceschi, S</creatorcontrib><creatorcontrib>La Vecchia, C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zucchetto, A</au><au>Dal Maso, L</au><au>Tavani, A</au><au>Montella, M</au><au>Ramazzotti, V</au><au>Talamini, R</au><au>Canzonieri, V</au><au>Garbeglio, A</au><au>Negri, E</au><au>Franceschi, S</au><au>La Vecchia, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>History of treated hypertension and diabetes mellitus and risk of renal cell cancer</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>18</volume><issue>3</issue><spage>596</spage><epage>600</epage><pages>596-600</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Background: An increased risk of renal cell cancer (RCC) has been reported in subjects with hypertension. Whether this association may vary according to sex, smoking, obesity, or RCC clinical presentation is unclear. Results on the link between diabetes mellitus and RCC are inconclusive. Patients and methods: We conducted an Italian multicenter case–control study, including 767 (494 men, 273 women) incident cases of RCC, under 80 years of age, and 1534 hospital controls, frequency-matched to cases. Multiple logistic regression models, conditioned to center, sex, and age, and adjusted for period of interview, education, smoking, and body mass were used to estimate odds ratios (OR). Results: Compared with subjects never treated, patients with a history of treated hypertension [OR = 1.7, 95% confidence interval (CI) 1.4–2.1] reported an excess risk of RCC. This pattern was confirmed in different strata of sex, education, smoking habits, body mass, tumor histological type, stage, or grade. The attributable risk of RCC for treated hypertension in this population was 16%. A slight, nonsignificant increased risk was found for history of diabetes mellitus (OR = 1.3, 95% CI 0.9–1.7). Conclusion: A possible causal role of hypertension in renal cell carcinogenesis is supported by the consistency of the direct association.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17158772</pmid><doi>10.1093/annonc/mdl438</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antihypertensive Agents - therapeutic use Antineoplastic agents Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Carcinoma, Renal Cell - epidemiology Carcinoma, Renal Cell - etiology Cardiology. Vascular system Case-Control Studies Diabetes Complications - epidemiology Diabetes Complications - etiology diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - epidemiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Humans hypertension Hypertension - complications Hypertension - drug therapy Hypertension - epidemiology Hypoglycemic Agents - therapeutic use Incidence Italy - epidemiology Kidney Neoplasms - epidemiology Kidney Neoplasms - etiology Kidneys Logistic Models Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Odds Ratio Pharmacology. Drug treatments renal cell cancer risk Risk Assessment Risk Factors Tumors of the urinary system |
| title | History of treated hypertension and diabetes mellitus and risk of renal cell cancer |
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