Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93

Background: The International Breast Cancer Study Group (IBCSG) conducted two complementary randomized trials to assess whether a treatment-free gap during adjuvant chemotherapy influenced outcome. Patients and methods: From 1993 to 1999, IBCSG Trials 13-93 and 14-93 enrolled 2215 premenopausal and...

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Veröffentlicht in:	Annals of oncology 2007-07, Vol.18 (7), p.1177-1184
Hauptverfasser:	Colleoni, Marco, Gelber, Shari, Simoncini, Edda, Pagani, Olivia, Gelber, Richard D, Price, Karen N, Castiglione-Gertsch, Monica, Coates, Alan S, Goldhirsch, Aron
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant therapy Adult Aged Antineoplastic agents Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology chemotherapy Chemotherapy, Adjuvant Cyclophosphamide - administration & dosage Disease-Free Survival Doxorubicin - administration & dosage Drug Administration Schedule early-stage breast cancer Epirubicin - administration & dosage estrogen receptor Female Fluorouracil - administration & dosage Gynecology. Andrology. Obstetrics Hematologic and hematopoietic diseases hormonal therapy Humans Kaplan-Meier Estimate Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lymph node positive Lymphatic Metastasis - pathology Mammary gland diseases Medical sciences Methotrexate - administration & dosage Middle Aged Neoplasm Recurrence, Local - epidemiology Pharmacology. Drug treatments Receptors, Estrogen - metabolism Tamoxifen - therapeutic use Tumors
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